Ubiquitin–proteasome pathway and cellular responses to oxidative stress

• Published in: Free radical biology & medicine Vol. 51; no. 1; pp. 5 - 16
• Main Authors: Shang, Fu, Taylor, Allen
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2011
• Subjects: Animals; Free radicals; Humans; Oxidation-Reduction; Oxidative Stress; Proteasome; proteasome endopeptidase complex; Proteasome Endopeptidase Complex - metabolism; Protein Binding; Protein quality control; proteolysis; Ubiquitin; Ubiquitin - metabolism; ubiquitin-protein ligase; ubiquitination; Ubiquitin; Oxidative stress; Free radicals; Protein quality control; Proteasome
• ISSN: 0891-5849; 1873-4596; 1873-4596
• DOI: 10.1016/j.freeradbiomed.2011.03.031

The ubiquitin–proteasome pathway (UPP) is the primary cytosolic proteolytic machinery for the selective degradation of various forms of damaged proteins. Thus, the UPP is an important protein quality control mechanism. In the canonical UPP, both ubiquitin and the 26S proteasome are involved. Substra...