Interspecies differences in coagulation profile

• Published in: Thrombosis and haemostasis Vol. 100; no. 3; p. 397
• Main Authors: Siller-Matula, Jolanta M, Plasenzotti, Roberto, Spiel, Alexander, Quehenberger, Peter, Jilma, Bernd
• Format: Journal Article
• Language: English
• Published: Germany 01.09.2008
• Subjects: Animals; Blood Coagulation; Blood Coagulation Tests - methods; Blood Coagulation Tests - standards; Blood Platelets - metabolism; Female; Humans; Male; Models, Animal; Rabbits; Rats; Rats, Sprague-Dawley; Sheep; Species Specificity; Thrombelastography - methods; Thrombin - chemistry

Many animals are used in research on blood coagulation and fibrinolysis, but the relevance of animal models to human health is often questioned because of differences between species. The objective was to find an appropriate animal species, which mimics the coagulation profile in humans most adequat...