TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 108; no. 20; pp. 8485 - 8490
• Main Authors: Revel, Florent G, Moreau, Jean-Luc, Gainetdinov, Raul R, Bradaia, Amyaouch, Sotnikova, Tatyana D, Mory, Roland, Durkin, Sean, Zbinden, Katrin Groebke, Norcross, Roger, Meyer, Claas A, Metzler, Veit, Chaboz, Sylvie, Ozmen, Laurence, Trube, Gerhard, Pouzet, Bruno, Bettler, Bernhard, Caron, Marc G, Wettstein, Joseph G, Hoener, Marius C
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 17.05.2011; National Acad Sciences
• Subjects: Agonists; amines; Amino acids; Animals; antagonists; Antipsychotic agents; Autoreceptors; behavior disorders; Benzodioxoles - pharmacology; Biogenic Monoamines - metabolism; Biological Sciences; Brain; Brain slice preparation; brain stem; Cells; Cocaine; Cynomolgus; dopamine; Dopamine - metabolism; Dopamine transporter; dorsal raphe nucleus; Dosage; fever; Firing rate; Gene expression; Glutamic acid receptors (ionotropic); Glutamine - metabolism; HEK293 Cells; Humans; Hyperactivity; Inurement; knockout mutants; Macaca fascicularis; Mental Disorders; Metabolites; Mice; Mutation; N-Methyl-D-aspartic acid receptors; Neuroleptics; Neuromodulation; Neurons; Neurotransmission; Norepinephrine; Phenylpropionates - pharmacology; Proteins; rats; Receptors; Receptors, G-Protein-Coupled - agonists; Receptors, G-Protein-Coupled - deficiency; Receptors, G-Protein-Coupled - metabolism; Rodents; Serotonin; Serotonin receptors; Serotonin S1 receptors; Synaptic Transmission - physiology; Trace amines

The trace amine-associated receptor 1 (TAAR1), activated by endogenous metabolites of amino acids like the trace amines p-tyramine and β-phenylethylamine, has proven to be an important modulator of the dopaminergic system and is considered a promising target for the treatment of neuropsychiatric di...