variable plasma quercetin response to 12-week quercetin supplementation in humans
Background/Objectives: Quercetin supplementation results in a variable plasma quercetin response in humans. The purpose of this study was to determine whether this variance is related to gender, age, body mass index (BMI), and other demographic and lifestyle factors. Subjects/Methods: Subjects (N=10...
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| Published in | European journal of clinical nutrition Vol. 64; no. 7; pp. 692 - 697 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.07.2010
Nature Publishing Group |
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| Online Access | Get full text |
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| Abstract | Background/Objectives: Quercetin supplementation results in a variable plasma quercetin response in humans. The purpose of this study was to determine whether this variance is related to gender, age, body mass index (BMI), and other demographic and lifestyle factors. Subjects/Methods: Subjects (N=1002, ages 18–85 years, 60% female and 40% male) were recruited from the community and randomized to one of three groups, with supplements administered using double-blinded procedures: Q-500 (500 mg/day), Q-1000 (1000 mg/day), or placebo. Subjects ingested two soft chew supplements twice daily during the 12-week study. Fasting blood samples were obtained pre- and post-study, analyzed for plasma quercetin, and then compared between and within groups by gender, age group (<40, 40–59, and 60 years), BMI (<25, 25–29.9, and 30 kg/m2), self-reported physical fitness level, and diet intake (food group servings). Results: Quercetin supplementation over 12 weeks caused a significant increase in overnight-fasted plasma quercetin, with a net increase of 332±21.0 and 516±30.8 μg/l for Q-500 and Q-1000 compared with 53.6±6.4 μg/l for placebo (interaction effect, P<0.001). The increase in plasma quercetin was highly variable within each quercetin supplementation group, but was unrelated to age, gender, BMI, fitness levels, or diet intake. Conclusions: In summary, quercetin supplementation in doses of 500 and 1000 mg/day caused large but highly variable increases in plasma quercetin that were unrelated to demographic or lifestyle factors. |
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| AbstractList | Quercetin supplementation results in a variable plasma quercetin response in humans. The purpose of this study was to determine whether this variance is related to gender, age, body mass index (BMI), and other demographic and lifestyle factors.
Subjects (N=1002, ages 18-85 years, 60% female and 40% male) were recruited from the community and randomized to one of three groups, with supplements administered using double-blinded procedures: Q-500 (500 mg/day), Q-1000 (1000 mg/day), or placebo. Subjects ingested two soft chew supplements twice daily during the 12-week study. Fasting blood samples were obtained pre- and post-study, analyzed for plasma quercetin, and then compared between and within groups by gender, age group (<40, 40-59, and >or=60 years), BMI (<25, 25-29.9, and >or=30 kg/m(2)), self-reported physical fitness level, and diet intake (food group servings).
Quercetin supplementation over 12 weeks caused a significant increase in overnight-fasted plasma quercetin, with a net increase of 332+/-21.0 and 516+/-30.8 microg/l for Q-500 and Q-1000 compared with 53.6+/-6.4 microg/l for placebo (interaction effect, P<0.001). The increase in plasma quercetin was highly variable within each quercetin supplementation group, but was unrelated to age, gender, BMI, fitness levels, or diet intake.
In summary, quercetin supplementation in doses of 500 and 1000 mg/day caused large but highly variable increases in plasma quercetin that were unrelated to demographic or lifestyle factors. Background/Objectives: Quercetin supplementation results in a variable plasma quercetin response in humans. The purpose of this study was to determine whether this variance is related to gender, age, body mass index (BMI), and other demographic and lifestyle factors. Subjects/Methods: Subjects (N = 1002, ages 18-85 years, 60% female and 40% male) were recruited from the community and randomized to one of three groups, with supplements administered using double-blinded procedures: Q-500 (500 mg/day), Q-1000 (1000 mg/day), or placebo. Subjects ingested two soft chew supplements twice daily during the 12-week study. Fasting blood samples were obtained pre- and post-study, analyzed for plasma quercetin, and then compared between and within groups by gender, age group (<40, 40-59, and X60 years), BMI (<25, 25-29.9, and ≥ 30 kg/[m.sup.2]), self-reported physical fitness level, and diet intake (food group servings). Results: Quercetin supplementation over 12 weeks caused a significant increase in overnight-fasted plasma quercetin, with a net increase of 332 ± 21.0 and 516 ± 30.8 µg/l for Q-500 and Q-1000 compared with 53.6 ± 6.4 µg/l for placebo (interaction effect, P<0.001). The increase in plasma quercetin was highly variable within each quercetin supplementation group, but was unrelated to age, gender, BMI, fitness levels, or diet intake. Conclusions: In summary, quercetin supplementation in doses of 500 and 1000 mg/day caused large but highly variable increases in plasma quercetin that were unrelated to demographic or lifestyle factors. European Journal of Clinical Nutrition (2010) 64, 692-697; doi: 10.1038/ejcn.2010.91; published online 2 June 2010 Keywords: quercetin; flavonoid; human; plasma; supplementation; variation Subjects/Methods: Subjects (N = 1002, ages 18-85 years, 60% female and 40% male) were recruited from the community and randomized to one of three groups, with supplements administered using double-blinded procedures: Q-500 (500 mg/day), Q-1000 (1000 mg/day), or placebo. Subjects ingested two soft chew supplements twice daily during the 12-week study. Fasting blood samples were obtained pre- and post-study, analyzed for plasma quercetin, and then compared between and within groups by gender, age group (<40, 40-59, and X60 years), BMI (<25, 25-29.9, and ≥ 30 kg/[m.sup.2]), self-reported physical fitness level, and diet intake (food group servings). European Journal of Clinical Nutrition (2010) 64, 692-697; doi: 10.1038/ejcn.2010.91; published online 2 June 2010 Background/Objectives: Quercetin supplementation results in a variable plasma quercetin response in humans. The purpose of this study was to determine whether this variance is related to gender, age, body mass index (BMI), and other demographic and lifestyle factors. Subjects/Methods: Subjects ( N =1002, ages 18–85 years, 60% female and 40% male) were recruited from the community and randomized to one of three groups, with supplements administered using double-blinded procedures: Q-500 (500 mg/day), Q-1000 (1000 mg/day), or placebo. Subjects ingested two soft chew supplements twice daily during the 12-week study. Fasting blood samples were obtained pre- and post-study, analyzed for plasma quercetin, and then compared between and within groups by gender, age group (<40, 40–59, and ⩾60 years), BMI (<25, 25–29.9, and ⩾30 kg/m 2 ), self-reported physical fitness level, and diet intake (food group servings). Results: Quercetin supplementation over 12 weeks caused a significant increase in overnight-fasted plasma quercetin, with a net increase of 332±21.0 and 516±30.8 μg/l for Q-500 and Q-1000 compared with 53.6±6.4 μg/l for placebo (interaction effect, P <0.001). The increase in plasma quercetin was highly variable within each quercetin supplementation group, but was unrelated to age, gender, BMI, fitness levels, or diet intake. Conclusions: In summary, quercetin supplementation in doses of 500 and 1000 mg/day caused large but highly variable increases in plasma quercetin that were unrelated to demographic or lifestyle factors. Background/Objectives:Quercetin supplementation results in a variable plasma quercetin response in humans. The purpose of this study was to determine whether this variance is related to gender, age, body mass index (BMI), and other demographic and lifestyle factors.Subjects/Methods:Subjects (N=1002, ages 18–85 years, 60% female and 40% male) were recruited from the community and randomized to one of three groups, with supplements administered using double-blinded procedures: Q-500 (500 mg/day), Q-1000 (1000 mg/day), or placebo. Subjects ingested two soft chew supplements twice daily during the 12-week study. Fasting blood samples were obtained pre- and post-study, analyzed for plasma quercetin, and then compared between and within groups by gender, age group (<40, 40–59, and ⩾60 years), BMI (<25, 25–29.9, and ⩾30 kg/m2), self-reported physical fitness level, and diet intake (food group servings).Results:Quercetin supplementation over 12 weeks caused a significant increase in overnight-fasted plasma quercetin, with a net increase of 332±21.0 and 516±30.8 μg/l for Q-500 and Q-1000 compared with 53.6±6.4 μg/l for placebo (interaction effect, P<0.001). The increase in plasma quercetin was highly variable within each quercetin supplementation group, but was unrelated to age, gender, BMI, fitness levels, or diet intake.Conclusions:In summary, quercetin supplementation in doses of 500 and 1000 mg/day caused large but highly variable increases in plasma quercetin that were unrelated to demographic or lifestyle factors. Quercetin supplementation results in a variable plasma quercetin response in humans. The purpose of this study was to determine whether this variance is related to gender, age, body mass index (BMI), and other demographic and lifestyle factors.BACKGROUND/OBJECTIVESQuercetin supplementation results in a variable plasma quercetin response in humans. The purpose of this study was to determine whether this variance is related to gender, age, body mass index (BMI), and other demographic and lifestyle factors.Subjects (N=1002, ages 18-85 years, 60% female and 40% male) were recruited from the community and randomized to one of three groups, with supplements administered using double-blinded procedures: Q-500 (500 mg/day), Q-1000 (1000 mg/day), or placebo. Subjects ingested two soft chew supplements twice daily during the 12-week study. Fasting blood samples were obtained pre- and post-study, analyzed for plasma quercetin, and then compared between and within groups by gender, age group (<40, 40-59, and >or=60 years), BMI (<25, 25-29.9, and >or=30 kg/m(2)), self-reported physical fitness level, and diet intake (food group servings).SUBJECTS/METHODSSubjects (N=1002, ages 18-85 years, 60% female and 40% male) were recruited from the community and randomized to one of three groups, with supplements administered using double-blinded procedures: Q-500 (500 mg/day), Q-1000 (1000 mg/day), or placebo. Subjects ingested two soft chew supplements twice daily during the 12-week study. Fasting blood samples were obtained pre- and post-study, analyzed for plasma quercetin, and then compared between and within groups by gender, age group (<40, 40-59, and >or=60 years), BMI (<25, 25-29.9, and >or=30 kg/m(2)), self-reported physical fitness level, and diet intake (food group servings).Quercetin supplementation over 12 weeks caused a significant increase in overnight-fasted plasma quercetin, with a net increase of 332+/-21.0 and 516+/-30.8 microg/l for Q-500 and Q-1000 compared with 53.6+/-6.4 microg/l for placebo (interaction effect, P<0.001). The increase in plasma quercetin was highly variable within each quercetin supplementation group, but was unrelated to age, gender, BMI, fitness levels, or diet intake.RESULTSQuercetin supplementation over 12 weeks caused a significant increase in overnight-fasted plasma quercetin, with a net increase of 332+/-21.0 and 516+/-30.8 microg/l for Q-500 and Q-1000 compared with 53.6+/-6.4 microg/l for placebo (interaction effect, P<0.001). The increase in plasma quercetin was highly variable within each quercetin supplementation group, but was unrelated to age, gender, BMI, fitness levels, or diet intake.In summary, quercetin supplementation in doses of 500 and 1000 mg/day caused large but highly variable increases in plasma quercetin that were unrelated to demographic or lifestyle factors.CONCLUSIONSIn summary, quercetin supplementation in doses of 500 and 1000 mg/day caused large but highly variable increases in plasma quercetin that were unrelated to demographic or lifestyle factors. Background/Objectives: Quercetin supplementation results in a variable plasma quercetin response in humans. The purpose of this study was to determine whether this variance is related to gender, age, body mass index (BMI), and other demographic and lifestyle factors. Subjects/Methods: Subjects (N=1002, ages 18–85 years, 60% female and 40% male) were recruited from the community and randomized to one of three groups, with supplements administered using double-blinded procedures: Q-500 (500 mg/day), Q-1000 (1000 mg/day), or placebo. Subjects ingested two soft chew supplements twice daily during the 12-week study. Fasting blood samples were obtained pre- and post-study, analyzed for plasma quercetin, and then compared between and within groups by gender, age group (<40, 40–59, and 60 years), BMI (<25, 25–29.9, and 30 kg/m2), self-reported physical fitness level, and diet intake (food group servings). Results: Quercetin supplementation over 12 weeks caused a significant increase in overnight-fasted plasma quercetin, with a net increase of 332±21.0 and 516±30.8 μg/l for Q-500 and Q-1000 compared with 53.6±6.4 μg/l for placebo (interaction effect, P<0.001). The increase in plasma quercetin was highly variable within each quercetin supplementation group, but was unrelated to age, gender, BMI, fitness levels, or diet intake. Conclusions: In summary, quercetin supplementation in doses of 500 and 1000 mg/day caused large but highly variable increases in plasma quercetin that were unrelated to demographic or lifestyle factors. BACKGROUND/OBJECTIVES: Quercetin supplementation results in a variable plasma quercetin response in humans. The purpose of this study was to determine whether this variance is related to gender, age, body mass index (BMI), and other demographic and lifestyle factors. SUBJECTS/METHODS: Subjects (N=1002, ages 18-85 years, 60% female and 40% male) were recruited from the community and randomized to one of three groups, with supplements administered using double-blinded procedures: Q-500 (500 mg/day), Q-1000 (1000 mg/day), or placebo. Subjects ingested two soft chew supplements twice daily during the 12-week study. Fasting blood samples were obtained pre- and post-study, analyzed for plasma quercetin, and then compared between and within groups by gender, age group (<40, 40-59, and >or=60 years), BMI (<25, 25-29.9, and >or=30 kg/m(2)), self-reported physical fitness level, and diet intake (food group servings). RESULTS: Quercetin supplementation over 12 weeks caused a significant increase in overnight-fasted plasma quercetin, with a net increase of 332+/-21.0 and 516+/-30.8 microg/l for Q-500 and Q-1000 compared with 53.6+/-6.4 microg/l for placebo (interaction effect, P<0.001). The increase in plasma quercetin was highly variable within each quercetin supplementation group, but was unrelated to age, gender, BMI, fitness levels, or diet intake. CONCLUSIONS: In summary, quercetin supplementation in doses of 500 and 1000 mg/day caused large but highly variable increases in plasma quercetin that were unrelated to demographic or lifestyle factors. [PUBLICATION ABSTRACT] |
| Audience | Professional Academic |
| Author | Knab, A.M Austin, M.D Jin, F Shanely, R.A Nieman, D.C Sha, W |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20517329$$D View this record in MEDLINE/PubMed |
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| Title | variable plasma quercetin response to 12-week quercetin supplementation in humans |
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