On the nature of mycobacteriophage diversity and host preference

• Published in: Virology (New York, N.Y.) Vol. 434; no. 2; pp. 187 - 201
• Main Authors: Jacobs-Sera, Deborah, Marinelli, Laura J, Bowman, Charles, Broussard, Gregory W, Guerrero Bustamante, Carlos, Boyle, Michelle M, Petrova, Zaritza O, Dedrick, Rebekah M, Pope, Welkin H, Science Education Alliance Phage Hunters Advancing Genomics and Evolutionary Science (SEA-PHAGES) program, Modlin, Robert L, Hendrix, Roger W, Hatfull, Graham F
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.12.2012
• Subjects: Adsorption; Bacteriophage; Cluster Analysis; DNA; Genetic Variation; Genome; Genome, Viral; Genomes; Genotype; Host preferences; Host range; Host Specificity; Infection; Infectious Disease; Mutation; Mycobacteriophage; Mycobacteriophages - classification; Mycobacteriophages - genetics; Mycobacteriophages - physiology; Mycobacterium smegmatis; Mycobacterium smegmatis - virology; Mycobacterium tuberculosis; Mycobacterium tuberculosis - virology; Nucleotide sequence; Phages; Tails; Host range; Mycobacteriophage; Bacteriophage; Genome

Abstract The complete genome sequences of over 220 mycobacteriophages reveal them to be highly diverse, with numerous types sharing little or no nucleotide sequence identity with each other. We have determined the preferences of these phages for Mycobacterium tuberculosis and for other strains of My...