mTOR/p70S6K signaling distinguishes routine, maintenance-level autophagy from autophagic cell death during influenza A infection

• Published in: Virology (New York, N.Y.) Vol. 452; pp. 175 - 190
• Main Authors: Datan, Emmanuel, Shirazian, Alireza, Benjamin, Shawna, Matassov, Demetrius, Tinari, Antonella, Malorni, Walter, Lockshin, Richard A, Garcia-Sastre, Adolfo, Zakeri, Zahra
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2014
• Subjects: Apoptosis; Autophagy; Cell death; Humans; Infectious Disease; Influenza; Influenza A virus; Influenza A virus - genetics; Influenza A virus - physiology; Influenza, Human - enzymology; Influenza, Human - genetics; Influenza, Human - physiopathology; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; mTORC1/2; Multiprotein Complexes - genetics; Multiprotein Complexes - metabolism; p70S6K; Phosphatidylinositol 3-Kinases - genetics; Phosphatidylinositol 3-Kinases - metabolism; Rapamycin; Ribosomal Protein S6 Kinases, 70-kDa - genetics; Ribosomal Protein S6 Kinases, 70-kDa - metabolism; Signal Transduction; TOR Serine-Threonine Kinases - genetics; TOR Serine-Threonine Kinases - metabolism; Torin1; p70S6K; Cell death; Influenza; mTORC1/2; Rapamycin; Autophagy; Torin1; Apoptosis

Abstract Autophagy, a stress response activated in influenza A virus infection helps the cell avoid apoptosis. However, in the absence of apoptosis infected cells undergo vastly expanded autophagy and nevertheless die in the presence of necrostatin but not of autophagy inhibitors. Combinations of in...