Combined optical imaging and mammography of the healthy breast: Optical contrast derived from breast structure and compression

• Published in: IEEE transactions on medical imaging Vol. 28; no. 1; pp. 30 - 42
• Main Authors: Qianqian Fang, Carp, S.A., Selb, J., Boverman, G., Quan Zhang, Kopans, D.B., Moore, R.H., Miller, E.L., Brooks, D.H., Boas, D.A.
• Format: Journal Article
• Language: English
• Published: United States IEEE 01.01.2009; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Breast; Breast - anatomy & histology; Breast - chemistry; Breast imaging; Equipment Design; Female; Finite Element Analysis; Hemoglobins - analysis; Humans; Image coding; Image reconstruction; Imaging phantoms; Instruments; Mammography; Mammography - instrumentation; Mammography - methods; multimodality imaging; Muscles; Optical imaging; Optical saturation; Oxygen - blood; Phantoms, Imaging; Pressure - adverse effects; Pressure distribution; Radiographic Image Enhancement - instrumentation; Radiographic Image Enhancement - methods; Radiographic Image Interpretation, Computer-Assisted - instrumentation; Radiographic Image Interpretation, Computer-Assisted - methods; Subtraction Technique; tomography; Tomography, Optical - instrumentation; Tomography, Optical - methods; X-ray imaging

In this paper, we report new progress in developing the instrument and software platform of a combined X-ray mammography/diffuse optical breast imaging system. Particularly, we focus on system validation using a series of balloon phantom experiments and the optical image analysis of 49 healthy patie...