Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis

• Published in: Free radical biology & medicine Vol. 51; no. 1; pp. 88 - 96
• Main Authors: Neymotin, Arie, Calingasan, Noel Y., Wille, Elizabeth, Naseri, Nima, Petri, Susanne, Damiano, Maria, Liby, Karen T., Risingsong, Renee, Sporn, Michael, Beal, M. Flint, Kiaei, Mahmoud
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2011
• Subjects: Age; Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - drug therapy; Amyotrophic Lateral Sclerosis - metabolism; Animal models; Animals; Antioxidants; Cell culture; Cell Line; Cell Nucleus - enzymology; disease course; Disease Models, Animal; Free radicals; G93A; gene expression regulation; Inflammation; Inflammation - metabolism; Major Histocompatibility Complex - genetics; Mice; Mice, Transgenic; Mitochondria; Mitochondria - metabolism; Motor neuron degeneration; Motor task performance; mutants; Neurodegenerative diseases; Neurodegenerative Diseases - genetics; Neuroprotection; neuroprotective effect; NF-E2-Related Factor 2 - biosynthesis; NF-E2-Related Factor 2 - genetics; NF-E2-Related Factor 2 - metabolism; Nuclear transport; Oleanolic Acid - analogs & derivatives; Oleanolic Acid - metabolism; Oleanolic Acid - pharmacology; Oleanolic Acid - therapeutic use; Oxidative damage; Oxidative Stress; pathogenesis; proteins; Proteins - genetics; Proteins - metabolism; Regulatory sequences; RNA, Messenger - biosynthesis; sclerosis; Signal Transduction; SOD1; Superoxide dismutase; Superoxide Dismutase - biosynthesis; Superoxide Dismutase - genetics; Survival; Triterpenoids; weight loss; Western blotting; G93A; Free radicals; Triterpenoids; Oxidative damage; Inflammation; Motor neuron degeneration; SOD1

Oxidative damage, neuroinflammation, and mitochondrial dysfunction contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS), and these pathologic processes are tightly regulated by the Nrf2/ARE (NF-E2-related factor 2/antioxidant response element) signaling program. Therefore, modulatio...