COVID-19 and Obesity: Overlapping of Two Pandemics

Background: The coronavirus disease 2019 (COVID-19) pandemic has recently led to worldwide research efforts to identify subjects at greater risk of developing more severe illness: overall obesity displayed a strong correlation with critical illness and major severity of COVID-19 manifestations. Summ...

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Published inObesity facts Vol. 14; no. 6; pp. 579 - 585
Main Authors Gammone, Maria Alessandra, D’Orazio, Nicolantonio
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 24.09.2021
Karger Publishers
Subjects
Adipocytes
Adipose Tissue
Body fat
Chronic illnesses
COVID-19
Cytokines
Endocrine system
Homeostasis
Humans
Hypoxia
Infections
Inflammation
Insulin
Kinases
Metabolism
Mortality
Obesity
Obesity - complications
Obesity - epidemiology
pandemic
Pandemics
Proteins
Review
Review Article
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
thrombosis
Weight control
COVID-19
Obesity
Pandemic
Inflammation
Body fat
Thrombosis
Online AccessGet full text
ISSN1662-4025
1662-4033
1662-4033
DOI10.1159/000518386

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Abstract Background: The coronavirus disease 2019 (COVID-19) pandemic has recently led to worldwide research efforts to identify subjects at greater risk of developing more severe illness: overall obesity displayed a strong correlation with critical illness and major severity of COVID-19 manifestations. Summary: Obesity and metabolic disorders are closely linked to chronic systemic inflammation. The adipose tissue constitutes a source of cytokines, which configure a low-grade inflammation and a hypercoagulation status; in addition, diagnosis and care of obese patients are often complicated by excess weight and ventilation difficulties. Key Messages: This review aims to examine the intersection between obesity and adverse outcomes of COVID-19, in order to investigate its preventive and/or therapeutic potential in the management of obesity-related COVID-19 complications.
AbstractList Background: The coronavirus disease 2019 (COVID-19) pandemic has recently led to worldwide research efforts to identify subjects at greater risk of developing more severe illness: overall obesity displayed a strong correlation with critical illness and major severity of COVID-19 manifestations. Summary: Obesity and metabolic disorders are closely linked to chronic systemic inflammation. The adipose tissue constitutes a source of cytokines, which configure a low-grade inflammation and a hypercoagulation status; in addition, diagnosis and care of obese patients are often complicated by excess weight and ventilation difficulties. Key Messages: This review aims to examine the intersection between obesity and adverse outcomes of COVID-19, in order to investigate its preventive and/or therapeutic potential in the management of obesity-related COVID-19 complications.
The coronavirus disease 2019 (COVID-19) pandemic has recently led to worldwide research efforts to identify subjects at greater risk of developing more severe illness: overall obesity displayed a strong correlation with critical illness and major severity of COVID-19 manifestations. Obesity and metabolic disorders are closely linked to chronic systemic inflammation. The adipose tissue constitutes a source of cytokines, which configure a low-grade inflammation and a hypercoagulation status; in addition, diagnosis and care of obese patients are often complicated by excess weight and ventilation difficulties. Key Messages: This review aims to examine the intersection between obesity and adverse outcomes of COVID-19, in order to investigate its preventive and/or therapeutic potential in the management of obesity-related COVID-19 complications.
The coronavirus disease 2019 (COVID-19) pandemic has recently led to worldwide research efforts to identify subjects at greater risk of developing more severe illness: overall obesity displayed a strong correlation with critical illness and major severity of COVID-19 manifestations.BACKGROUNDThe coronavirus disease 2019 (COVID-19) pandemic has recently led to worldwide research efforts to identify subjects at greater risk of developing more severe illness: overall obesity displayed a strong correlation with critical illness and major severity of COVID-19 manifestations.Obesity and metabolic disorders are closely linked to chronic systemic inflammation. The adipose tissue constitutes a source of cytokines, which configure a low-grade inflammation and a hypercoagulation status; in addition, diagnosis and care of obese patients are often complicated by excess weight and ventilation difficulties. Key Messages: This review aims to examine the intersection between obesity and adverse outcomes of COVID-19, in order to investigate its preventive and/or therapeutic potential in the management of obesity-related COVID-19 complications.SUMMARYObesity and metabolic disorders are closely linked to chronic systemic inflammation. The adipose tissue constitutes a source of cytokines, which configure a low-grade inflammation and a hypercoagulation status; in addition, diagnosis and care of obese patients are often complicated by excess weight and ventilation difficulties. Key Messages: This review aims to examine the intersection between obesity and adverse outcomes of COVID-19, in order to investigate its preventive and/or therapeutic potential in the management of obesity-related COVID-19 complications.
Author D’Orazio, Nicolantonio
Gammone, Maria Alessandra
AuthorAffiliation Human and Clinical Nutrition Unit, Department of Medical, Oral and Biotechnological Sciences, University G. D'Annunzio, Chieti, Italy
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Cites_doi 10.1159/000515104
10.2478/joeb-2019-0013
10.2337/db08-1098
10.1055/s-0040-1713152
10.3390/md13042196
10.3389/fendo.2015.00019
10.1093/cid/ciaa415
10.1002/oby.22831
10.2478/joeb-2020-0005
10.1159/000510719
10.1016/j.mayocp.2020.05.006
10.1038/nrrheum.2016.209
10.2741/s545
10.1530/EJE-20-1163
10.1007/s40519-021-01173-w
10.1111/sji.12747
10.1152/ajpendo.00297.2015
10.1016/j.redox.2020.101615
10.3390/nu11112664
10.1136/bmjopen-2017-021232
10.1016/j.tem.2014.03.009
10.1016/j.bcp.2019.03.030
10.1161/CIRCULATIONAHA.120.047419
10.3390/molecules23051168
10.3390/md13106226
10.1111/jth.14818
10.1038/nrendo.2016.222
10.1001/jama.289.14.1799
10.1161/01.atv.0000048856.22331.50
10.1002/cphy.c170046
10.1097/MOL.0b013e32814e6d29
10.2741/s480
10.1111/jth.14975
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Issue 6
Keywords COVID-19
Obesity
Pandemic
Inflammation
Body fat
Thrombosis
Language English
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References Parra-Medina R, Herrera S, Mejia J. Systematic review of microthrombi in COVID-19 autopsies. Acta Haematol. 2021 Apr;19:1–8.
Cunningham JW, Vaduganathan M, Claggett BL, Jering KS, Bhatt AS, Rosenthal N, . Clinical outcomes in young US adults hospitalized with COVID-19. JAMA Intern Med. 2020 Sep 9;181(3):379–81.
Subramanian A, Anand A, Adderley NJ, Okoth K, Toulis KA, Gokhale K, . Increased COVID-19 infections in women with polycystic ovary syndrome: a population-based study. Eur J Endocrinol. 2021 May;184(5):637–45.
Sanchis-Gomar F, Lavie CJ, Mehra MR, Henry BM, Lippi G. Obesity and outcomes in COVID-19: when an epidemic and pandemic collide. Mayo Clin Proc. 2020;95:1445–53.
Rodríguez A, Ezquerro S, Méndez-Giménez L, Becerril S, Frühbeck G. Revisiting the adipocyte: a model for integration of cytokine signaling in the regulation of energy metabolism. Am J Physiol Endocrinol Metab. 2015 Oct 15;309(8):E691–714.
Bikdeli B, Madhavan MV, Gupta A, Jimenez D, Burton JR, Der Nigoghossian C, ; Global COVID-19 Thrombosis Collaborative Group. Pharmacological agents targeting thromboinflammation in COVID-19: review and implications for future research. Thromb Haemost. 2020;120(7):1004–24.
Lighter J, Phillips M, Hochman S, Sterling S, Johnson D, Francois F, . Obesity in patients younger than 60 years is a risk factor for COVID-19 hospital admission. Clin Infect Dis. 2020;71(15):896–7.
Abella V, Scotece M, Conde J, Pino J, Gonzalez-Gay MA, Gómez-Reino JJ, . Leptin in the interplay of inflammation, metabolism and immune system disorders. Nat Rev Rheumatol. 2017;13:100–9.
Sudhakar M, Silambanan S, Chandran AS, Prabhakaran AA, Ramakrishnan R. C-Reactive Protein (CRP) and leptin receptor in obesity: binding of monomeric CRP to leptin receptor. Front Immunol. 2018 May 29;9:1167.
Gammone MA, D’Orazio N. Anti-obesity activity of the marine carotenoid fucoxanthin. Mar Drugs. 2015;13(4):2196–214.
Campbell CM, Kahwash R. Will complement inhibition be the new target in treating COVID-19-related systemic thrombosis. Circulation. 2020;141(22):1739–41.
Simonnet A, Chetboun M, Poissy J, Raverdy V, Noulette J, Duhamel A, . High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation. Obesity. 2020;28(7):1195–9.
Goossens GH, Dicker D, Farpour-Lambert NJ, Frühbeck G, Mullerova D, Woodward E, . Obesity and COVID-19: a perspective from the European Association for the study of obesity on immunological perturbations, therapeutic challenges, and opportunities in obesity. Obes Facts. 2020;13(4):439–52.
Daryabor G, Kabelitz D, Kalantar K. An update on immune dysregulation in obesity-related insulin resistance. Scand J Immunol. 2019;89:e12747.
Alessi MC, Poggi M, Juhan-Vague I. Plasminogen activator inhibitor-1, adipose tissue and insulin resistance. Curr Opin Lipidol. 2007;18:240–5.
Francisco V, Ruiz-Fernández C, Pino J, Mera A, González-Gay MA, Gómez R, . Adipokines: linking metabolic syndrome, the immune system, and arthritic diseases. Biochem Pharmacol. 2019;165:196–206.
deGit KCG, Peterse C, Beerens S, Luijendijk MCM, van der Plasse G, la Fleur SE, . Is leptin resistance the cause or the consequence of diet-induced obesity. Int J Obes. 2018;42(8):1445–57.
Wichmann D, Sperhake JP, Lütgehetmann M. Autopsy findings and venous thromboembolism in patients with COVID-19: a prospective cohort study. Ann Intern Med. 2020;173(4):268–77.
Rashad NM, El-Shabrawy RM, Sabry HM, Fathy HA, Said D, Yousef MS. Interleukin-6 and hs-CRP as early diagnostic biomarkers for obesity-related peripheral polyneuropathy in non-diabetic patients. Egypt J Immunol. 2018;25(2):153–65.
Gkogkou E, Barnasas G, Vougas K, Trougakos IP. Expression profiling meta-analysis of ACE2 and TMPRSS2, the putative anti-inflammatory receptor and priming protease of SARS-CoV-2 in human cells, and identification of putative modulators. Redox Biol. 2020 Sep;36:101615.
Gammone MA, Riccioni G, D’Orazio N. Marine carotenoids against oxidative stress: effects on human health. Mar Drugs. 2015 Sep 30;13(10):6226–46.
Gammone MA, D’Orazio N. Assessment of body composition and nutritional risks in young ballet dancers–the bioelectrical impedance analysis. J Electr Bioimpedance. 2020;11(1):26–30.
Fang H, Judd RL. Adiponectin regulation and function. Compr Physiol. 2018;8:1031–63.
Maury E, Brichard SM. Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Mol Cell Endocrinol. 2010 Jan 15;314(1):1–16.
Marongiu F, Grandone E, Barcellona D. Pulmonary thrombosis in 2019-nCoV pneumonia. J Thromb Haemost. 2020;18(6):1511–3.
Riccioni G, Gammone MA, Currenti W, D’Orazio N. Effectiveness and safety of dietetic supplementation of a new nutraceutical on lipid profile and serum inflammation biomarkers in hypercholesterolemic patients. Molecules. 2018;23(5):1168.
Esposito K, Pontillo A, Di Palo C, Giugliano G, Masella M, Marfella R, . Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA. 2003;289(14):1799–804.
Gammone MA, Pluchinotta FR, Bergante S, Tettamanti G, D’Orazio N. Prevention of cardiovascular diseases with carotenoids. Front Biosci (Schol Ed). 2017 Jan 1;9:165–71.
Trayhurn P, Alomar SY. Oxygen deprivation and the cellular response to hypoxia in adipocytes–perspectives on white and brown adipose tissues in obesity. Front Endocrinol. 2015;6:19.
Longmore DK, Miller JE, Bekkering S, Saner C, Mifsud E, Zhu Y, ; International BMI-COVID Consortium; International BMI-COVID Consortium. Diabetes and overweight/obesity are independent, nonadditive risk factors for in-hospital severity of COVID-19: an international, multicenter retrospective meta-analysis. Diabetes Care. 2021 Apr 15;44(6):1281–1290.
Ohashi K, Shibata R, Murohara T, Ouchi N. Role of anti-inflammatory adipokines in obesity-related diseases. Trends Endocrinol Metab. 2014;25(7):348–55.
Pasarica M, Sereda OR, Redman LM, Albarado DC, Hymel DT, Roan LE, . Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response. Diabetes. 2009;58:718–25.
Lelis D, de F, Freitas DF, de Machado AS, Crespo TS, Santos SHS. Angiotensin(1-7), adipokines and inflammation. Metab Clin Exp. 2019;95:36–45.
Sengenes C, Miranville A, Lolmede K, Curat CA, Bouloumie A. The role of endothelial cells in inflamed adipose tissue. J Intern Med. 2007;262:415–21.
Landecho MF, Tuero C, Valentí V, Bilbao I, de la Higuera M, Frühbeck G. Relevance of leptin and other adipokines in obesity-associated cardiovascular risk. Nutrients. 2019;11(11):2664.
Maury E, Noel L, Detry R, Brichard SM. In vitro hyper-responsiveness to TNF-{alpha} contributes to adipokine dysregulation in omental adipocytes of obese subjects. J Clin Endocrinol Metab. 2009 Mar 1;23(3):422.
Gammone MA, D’Orazio N. Obesity and COVID-19: a detrimental intersection. Front Endocrinol. 2021 Apr 30;12:652639.
Cui H, López M, Rahmouni K. The cellular and molecular bases of leptin and ghrelin resistance in obesity. Nat Rev Endocrinol. 2017;13(6):338–51.
Park CH, Do JG, Lee YT, Yoon KJ. Sarcopenic obesity associated with high-sensitivity C-reactive protein in age and sex comparison: a two-center study in South Korea. BMJ Open. 2018;8(9):e021232.
Iba T, Levy JH, Levi M, Thachil J. Coagulopathy in COVID-19. J Thromb Haemost. 2020;18(9):2103–9.
deHeredia FP, Gómez-Martínez S, Marcos A. Obesity, inflammation and the immune system. Proc Nutr Soc. 2012;71:332–8.
Gammone MA, Ficoneri C, D’Orazio N. Assessment of body composition in oncologic patients: experimental survey on the role of bioimpedentiometric analysis. J Electr Bioimpedance. 2019;10(1):90–5.
Landecho MF, Marin-Oto M, Recalde-Zamacona B, Bilbao I, Frühbeck G. Obesity as an adipose tissue dysfunction disease and a risk factor for infections–Covid-19 as a case study. Eur J Intern Med. 2021 Apr 2;S0953–6205(21):00097–2.
Kumada M, Kihara S, Sumitsuji S, Kawamoto T, Matsumoto S, Ouchi N, . Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol. 2003;23:85.
Gammone MA, Riccioni G, Massari F, D’Orazio N. Beneficial effect of ivabradine against cardiovascular diseases. Front Biosci (Schol Ed). 2020 Mar 1;12:161–72. http://dx.doi.org/10.2741/s545.161
Malavazos AE, Secchi F, Basilico S, Capitanio G, Boveri S, Milani V, . Abdominal obesity phenotype is associated with COVID-19 chest X-ray severity score better than BMI-based obesity. Eat Weight Disord. 2021 Apr 5:1–15. Epub ahead of print. http://dx.doi.org/10.1007/s40519-021-01173-w.
ref13
ref12
ref15
ref14
ref31
ref30
ref11
ref33
ref10
ref32
ref2
ref1
ref17
ref16
ref19
ref18
ref24
ref23
ref26
ref25
ref20
ref22
ref21
ref28
ref27
ref29
ref8
ref7
ref9
ref4
ref3
ref6
ref5
References_xml – reference: Ohashi K, Shibata R, Murohara T, Ouchi N. Role of anti-inflammatory adipokines in obesity-related diseases. Trends Endocrinol Metab. 2014;25(7):348–55.
– reference: Daryabor G, Kabelitz D, Kalantar K. An update on immune dysregulation in obesity-related insulin resistance. Scand J Immunol. 2019;89:e12747.
– reference: Campbell CM, Kahwash R. Will complement inhibition be the new target in treating COVID-19-related systemic thrombosis. Circulation. 2020;141(22):1739–41.
– reference: Goossens GH, Dicker D, Farpour-Lambert NJ, Frühbeck G, Mullerova D, Woodward E, . Obesity and COVID-19: a perspective from the European Association for the study of obesity on immunological perturbations, therapeutic challenges, and opportunities in obesity. Obes Facts. 2020;13(4):439–52.
– reference: Riccioni G, Gammone MA, Currenti W, D’Orazio N. Effectiveness and safety of dietetic supplementation of a new nutraceutical on lipid profile and serum inflammation biomarkers in hypercholesterolemic patients. Molecules. 2018;23(5):1168.
– reference: Park CH, Do JG, Lee YT, Yoon KJ. Sarcopenic obesity associated with high-sensitivity C-reactive protein in age and sex comparison: a two-center study in South Korea. BMJ Open. 2018;8(9):e021232.
– reference: Kumada M, Kihara S, Sumitsuji S, Kawamoto T, Matsumoto S, Ouchi N, . Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol. 2003;23:85.
– reference: Rashad NM, El-Shabrawy RM, Sabry HM, Fathy HA, Said D, Yousef MS. Interleukin-6 and hs-CRP as early diagnostic biomarkers for obesity-related peripheral polyneuropathy in non-diabetic patients. Egypt J Immunol. 2018;25(2):153–65.
– reference: Lighter J, Phillips M, Hochman S, Sterling S, Johnson D, Francois F, . Obesity in patients younger than 60 years is a risk factor for COVID-19 hospital admission. Clin Infect Dis. 2020;71(15):896–7.
– reference: Landecho MF, Marin-Oto M, Recalde-Zamacona B, Bilbao I, Frühbeck G. Obesity as an adipose tissue dysfunction disease and a risk factor for infections–Covid-19 as a case study. Eur J Intern Med. 2021 Apr 2;S0953–6205(21):00097–2.
– reference: Maury E, Noel L, Detry R, Brichard SM. In vitro hyper-responsiveness to TNF-{alpha} contributes to adipokine dysregulation in omental adipocytes of obese subjects. J Clin Endocrinol Metab. 2009 Mar 1;23(3):422.
– reference: Marongiu F, Grandone E, Barcellona D. Pulmonary thrombosis in 2019-nCoV pneumonia. J Thromb Haemost. 2020;18(6):1511–3.
– reference: Sengenes C, Miranville A, Lolmede K, Curat CA, Bouloumie A. The role of endothelial cells in inflamed adipose tissue. J Intern Med. 2007;262:415–21.
– reference: Landecho MF, Tuero C, Valentí V, Bilbao I, de la Higuera M, Frühbeck G. Relevance of leptin and other adipokines in obesity-associated cardiovascular risk. Nutrients. 2019;11(11):2664.
– reference: Wichmann D, Sperhake JP, Lütgehetmann M. Autopsy findings and venous thromboembolism in patients with COVID-19: a prospective cohort study. Ann Intern Med. 2020;173(4):268–77.
– reference: Gammone MA, Pluchinotta FR, Bergante S, Tettamanti G, D’Orazio N. Prevention of cardiovascular diseases with carotenoids. Front Biosci (Schol Ed). 2017 Jan 1;9:165–71.
– reference: Rodríguez A, Ezquerro S, Méndez-Giménez L, Becerril S, Frühbeck G. Revisiting the adipocyte: a model for integration of cytokine signaling in the regulation of energy metabolism. Am J Physiol Endocrinol Metab. 2015 Oct 15;309(8):E691–714.
– reference: deGit KCG, Peterse C, Beerens S, Luijendijk MCM, van der Plasse G, la Fleur SE, . Is leptin resistance the cause or the consequence of diet-induced obesity. Int J Obes. 2018;42(8):1445–57.
– reference: Longmore DK, Miller JE, Bekkering S, Saner C, Mifsud E, Zhu Y, ; International BMI-COVID Consortium; International BMI-COVID Consortium. Diabetes and overweight/obesity are independent, nonadditive risk factors for in-hospital severity of COVID-19: an international, multicenter retrospective meta-analysis. Diabetes Care. 2021 Apr 15;44(6):1281–1290.
– reference: Parra-Medina R, Herrera S, Mejia J. Systematic review of microthrombi in COVID-19 autopsies. Acta Haematol. 2021 Apr;19:1–8.
– reference: Gkogkou E, Barnasas G, Vougas K, Trougakos IP. Expression profiling meta-analysis of ACE2 and TMPRSS2, the putative anti-inflammatory receptor and priming protease of SARS-CoV-2 in human cells, and identification of putative modulators. Redox Biol. 2020 Sep;36:101615.
– reference: Cunningham JW, Vaduganathan M, Claggett BL, Jering KS, Bhatt AS, Rosenthal N, . Clinical outcomes in young US adults hospitalized with COVID-19. JAMA Intern Med. 2020 Sep 9;181(3):379–81.
– reference: Trayhurn P, Alomar SY. Oxygen deprivation and the cellular response to hypoxia in adipocytes–perspectives on white and brown adipose tissues in obesity. Front Endocrinol. 2015;6:19.
– reference: Gammone MA, Ficoneri C, D’Orazio N. Assessment of body composition in oncologic patients: experimental survey on the role of bioimpedentiometric analysis. J Electr Bioimpedance. 2019;10(1):90–5.
– reference: Gammone MA, D’Orazio N. Anti-obesity activity of the marine carotenoid fucoxanthin. Mar Drugs. 2015;13(4):2196–214.
– reference: Gammone MA, Riccioni G, Massari F, D’Orazio N. Beneficial effect of ivabradine against cardiovascular diseases. Front Biosci (Schol Ed). 2020 Mar 1;12:161–72. http://dx.doi.org/10.2741/s545.161
– reference: Gammone MA, D’Orazio N. Obesity and COVID-19: a detrimental intersection. Front Endocrinol. 2021 Apr 30;12:652639.
– reference: Malavazos AE, Secchi F, Basilico S, Capitanio G, Boveri S, Milani V, . Abdominal obesity phenotype is associated with COVID-19 chest X-ray severity score better than BMI-based obesity. Eat Weight Disord. 2021 Apr 5:1–15. Epub ahead of print. http://dx.doi.org/10.1007/s40519-021-01173-w.
– reference: Lelis D, de F, Freitas DF, de Machado AS, Crespo TS, Santos SHS. Angiotensin(1-7), adipokines and inflammation. Metab Clin Exp. 2019;95:36–45.
– reference: Bikdeli B, Madhavan MV, Gupta A, Jimenez D, Burton JR, Der Nigoghossian C, ; Global COVID-19 Thrombosis Collaborative Group. Pharmacological agents targeting thromboinflammation in COVID-19: review and implications for future research. Thromb Haemost. 2020;120(7):1004–24.
– reference: Cui H, López M, Rahmouni K. The cellular and molecular bases of leptin and ghrelin resistance in obesity. Nat Rev Endocrinol. 2017;13(6):338–51.
– reference: Alessi MC, Poggi M, Juhan-Vague I. Plasminogen activator inhibitor-1, adipose tissue and insulin resistance. Curr Opin Lipidol. 2007;18:240–5.
– reference: Esposito K, Pontillo A, Di Palo C, Giugliano G, Masella M, Marfella R, . Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA. 2003;289(14):1799–804.
– reference: Gammone MA, Riccioni G, D’Orazio N. Marine carotenoids against oxidative stress: effects on human health. Mar Drugs. 2015 Sep 30;13(10):6226–46.
– reference: Sanchis-Gomar F, Lavie CJ, Mehra MR, Henry BM, Lippi G. Obesity and outcomes in COVID-19: when an epidemic and pandemic collide. Mayo Clin Proc. 2020;95:1445–53.
– reference: Pasarica M, Sereda OR, Redman LM, Albarado DC, Hymel DT, Roan LE, . Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response. Diabetes. 2009;58:718–25.
– reference: Francisco V, Ruiz-Fernández C, Pino J, Mera A, González-Gay MA, Gómez R, . Adipokines: linking metabolic syndrome, the immune system, and arthritic diseases. Biochem Pharmacol. 2019;165:196–206.
– reference: Gammone MA, D’Orazio N. Assessment of body composition and nutritional risks in young ballet dancers–the bioelectrical impedance analysis. J Electr Bioimpedance. 2020;11(1):26–30.
– reference: Simonnet A, Chetboun M, Poissy J, Raverdy V, Noulette J, Duhamel A, . High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation. Obesity. 2020;28(7):1195–9.
– reference: Fang H, Judd RL. Adiponectin regulation and function. Compr Physiol. 2018;8:1031–63.
– reference: Subramanian A, Anand A, Adderley NJ, Okoth K, Toulis KA, Gokhale K, . Increased COVID-19 infections in women with polycystic ovary syndrome: a population-based study. Eur J Endocrinol. 2021 May;184(5):637–45.
– reference: deHeredia FP, Gómez-Martínez S, Marcos A. Obesity, inflammation and the immune system. Proc Nutr Soc. 2012;71:332–8.
– reference: Sudhakar M, Silambanan S, Chandran AS, Prabhakaran AA, Ramakrishnan R. C-Reactive Protein (CRP) and leptin receptor in obesity: binding of monomeric CRP to leptin receptor. Front Immunol. 2018 May 29;9:1167.
– reference: Maury E, Brichard SM. Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Mol Cell Endocrinol. 2010 Jan 15;314(1):1–16.
– reference: Iba T, Levy JH, Levi M, Thachil J. Coagulopathy in COVID-19. J Thromb Haemost. 2020;18(9):2103–9.
– reference: Abella V, Scotece M, Conde J, Pino J, Gonzalez-Gay MA, Gómez-Reino JJ, . Leptin in the interplay of inflammation, metabolism and immune system disorders. Nat Rev Rheumatol. 2017;13:100–9.
– ident: ref24
  doi: 10.1159/000515104
– ident: ref33
  doi: 10.2478/joeb-2019-0013
– ident: ref17
  doi: 10.2337/db08-1098
– ident: ref27
  doi: 10.1055/s-0040-1713152
– ident: ref6
  doi: 10.3390/md13042196
– ident: ref20
  doi: 10.3389/fendo.2015.00019
– ident: ref28
  doi: 10.1093/cid/ciaa415
– ident: ref29
  doi: 10.1002/oby.22831
– ident: ref32
  doi: 10.2478/joeb-2020-0005
– ident: ref3
  doi: 10.1159/000510719
– ident: ref1
  doi: 10.1016/j.mayocp.2020.05.006
– ident: ref7
  doi: 10.1038/nrrheum.2016.209
– ident: ref15
  doi: 10.2741/s545
– ident: ref31
  doi: 10.1530/EJE-20-1163
– ident: ref30
  doi: 10.1007/s40519-021-01173-w
– ident: ref18
  doi: 10.1111/sji.12747
– ident: ref19
  doi: 10.1152/ajpendo.00297.2015
– ident: ref2
  doi: 10.1016/j.redox.2020.101615
– ident: ref5
  doi: 10.3390/nu11112664
– ident: ref21
  doi: 10.1136/bmjopen-2017-021232
– ident: ref10
  doi: 10.1016/j.tem.2014.03.009
– ident: ref4
  doi: 10.1016/j.bcp.2019.03.030
– ident: ref22
  doi: 10.1161/CIRCULATIONAHA.120.047419
– ident: ref13
  doi: 10.3390/molecules23051168
– ident: ref16
  doi: 10.3390/md13106226
– ident: ref23
  doi: 10.1111/jth.14818
– ident: ref8
  doi: 10.1038/nrendo.2016.222
– ident: ref12
  doi: 10.1001/jama.289.14.1799
– ident: ref11
  doi: 10.1161/01.atv.0000048856.22331.50
– ident: ref9
  doi: 10.1002/cphy.c170046
– ident: ref26
  doi: 10.1097/MOL.0b013e32814e6d29
– ident: ref14
  doi: 10.2741/s480
– ident: ref25
  doi: 10.1111/jth.14975
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Snippet Background: The coronavirus disease 2019 (COVID-19) pandemic has recently led to worldwide research efforts to identify subjects at greater risk of developing...
The coronavirus disease 2019 (COVID-19) pandemic has recently led to worldwide research efforts to identify subjects at greater risk of developing more severe...
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SubjectTerms Adipocytes
Adipose Tissue
Body fat
Chronic illnesses
COVID-19
Cytokines
Endocrine system
Homeostasis
Humans
Hypoxia
Infections
Inflammation
Insulin
Kinases
Metabolism
Mortality
Obesity
Obesity - complications
Obesity - epidemiology
pandemic
Pandemics
Proteins
Review
Review Article
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
thrombosis
Weight control
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Title COVID-19 and Obesity: Overlapping of Two Pandemics
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