Genome-wide association analyses identify two susceptibility loci for pachychoroid disease central serous chorioretinopathy

The recently emerged pachychoroid concept has changed the understanding of age-related macular degeneration (AMD), which is a major cause of blindness; recent studies attributed AMD in part to pachychoroid disease central serous chorioretinopathy (CSC), suggesting the importance of elucidating the C...

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Published inCommunications biology Vol. 2; no. 1; p. 468
Main Authors Hosoda, Yoshikatsu, Miyake, Masahiro, Schellevis, Rosa L., Boon, Camiel J. F., Hoyng, Carel B., Miki, Akiko, Meguro, Akira, Sakurada, Yoichi, Yoneyama, Seigo, Takasago, Yukari, Hata, Masayuki, Muraoka, Yuki, Nakanishi, Hideo, Oishi, Akio, Ooto, Sotaro, Tamura, Hiroshi, Uji, Akihito, Miyata, Manabu, Takahashi, Ayako, Ueda-Arakawa, Naoko, Tajima, Atsushi, Sato, Takehiro, Mizuki, Nobuhisa, Shiragami, Chieko, Iida, Tomohiro, Khor, Chiea Chuen, Wong, Tien Yin, Yamada, Ryo, Honda, Shigeru, de Jong, Eiko K., Hollander, Anneke I. den, Matsuda, Fumihiko, Yamashiro, Kenji, Tsujikawa, Akitaka
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 12.12.2019
Nature Publishing Group
Subjects
45/43
631/208/205/2138
692/699/3161/3175
Age
Alleles
Biology
Biomedical and Life Sciences
Blindness
Case-Control Studies
Central Serous Chorioretinopathy - epidemiology
Central Serous Chorioretinopathy - genetics
Computational Biology - methods
Databases, Genetic
Europe - epidemiology
Female
Gene Expression
Genetic Loci
Genetic Predisposition to Disease
Genome-wide association studies
Genome-Wide Association Study
Genomes
Humans
Life Sciences
Macular degeneration
Male
Odds Ratio
Pathogenesis
Quantitative Trait Loci
Europe
Retinal diseases
Genome-wide association studies
Online AccessGet full text
ISSN2399-3642
2399-3642
DOI10.1038/s42003-019-0712-z

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Abstract The recently emerged pachychoroid concept has changed the understanding of age-related macular degeneration (AMD), which is a major cause of blindness; recent studies attributed AMD in part to pachychoroid disease central serous chorioretinopathy (CSC), suggesting the importance of elucidating the CSC pathogenesis. Our large genome-wide association study followed by validation studies in three independent Japanese and European cohorts, consisting of 1546 CSC samples and 13,029 controls, identified two novel CSC susceptibility loci: TNFRSF10A-LOC389641 and near GATA5 (rs13278062, odds ratio = 1.35, P  = 1.26 × 10 −13 ; rs6061548, odds ratio = 1.63, P  = 5.36 × 10 −15 ). A T allele at TNFRSF10A-LOC389641 rs13278062, a risk allele for CSC, is known to be a risk allele for AMD. This study not only identified new susceptibility genes for CSC, but also improves the understanding of the pathogenesis of AMD. Yoshikatsu Hosoda et al. present a genome-wide association study in Japanese and European cohorts, identifying genes related to central serous chorioretinopathy pathogenesis. They report two novel susceptibility loci, one of which is a known risk allele for age-related macular degeneration.
AbstractList The recently emerged pachychoroid concept has changed the understanding of age-related macular degeneration (AMD), which is a major cause of blindness; recent studies attributed AMD in part to pachychoroid disease central serous chorioretinopathy (CSC), suggesting the importance of elucidating the CSC pathogenesis. Our large genome-wide association study followed by validation studies in three independent Japanese and European cohorts, consisting of 1546 CSC samples and 13,029 controls, identified two novel CSC susceptibility loci: TNFRSF10A-LOC389641 and near GATA5 (rs13278062, odds ratio = 1.35, P = 1.26 × 10-13; rs6061548, odds ratio = 1.63, P = 5.36 × 10-15). A T allele at TNFRSF10A-LOC389641 rs13278062, a risk allele for CSC, is known to be a risk allele for AMD. This study not only identified new susceptibility genes for CSC, but also improves the understanding of the pathogenesis of AMD.The recently emerged pachychoroid concept has changed the understanding of age-related macular degeneration (AMD), which is a major cause of blindness; recent studies attributed AMD in part to pachychoroid disease central serous chorioretinopathy (CSC), suggesting the importance of elucidating the CSC pathogenesis. Our large genome-wide association study followed by validation studies in three independent Japanese and European cohorts, consisting of 1546 CSC samples and 13,029 controls, identified two novel CSC susceptibility loci: TNFRSF10A-LOC389641 and near GATA5 (rs13278062, odds ratio = 1.35, P = 1.26 × 10-13; rs6061548, odds ratio = 1.63, P = 5.36 × 10-15). A T allele at TNFRSF10A-LOC389641 rs13278062, a risk allele for CSC, is known to be a risk allele for AMD. This study not only identified new susceptibility genes for CSC, but also improves the understanding of the pathogenesis of AMD.
The recently emerged pachychoroid concept has changed the understanding of age-related macular degeneration (AMD), which is a major cause of blindness; recent studies attributed AMD in part to pachychoroid disease central serous chorioretinopathy (CSC), suggesting the importance of elucidating the CSC pathogenesis. Our large genome-wide association study followed by validation studies in three independent Japanese and European cohorts, consisting of 1546 CSC samples and 13,029 controls, identified two novel CSC susceptibility loci: TNFRSF10A-LOC389641 and near GATA5 (rs13278062, odds ratio = 1.35, P  = 1.26 × 10 −13 ; rs6061548, odds ratio = 1.63, P  = 5.36 × 10 −15 ). A T allele at TNFRSF10A-LOC389641 rs13278062, a risk allele for CSC, is known to be a risk allele for AMD. This study not only identified new susceptibility genes for CSC, but also improves the understanding of the pathogenesis of AMD. Yoshikatsu Hosoda et al. present a genome-wide association study in Japanese and European cohorts, identifying genes related to central serous chorioretinopathy pathogenesis. They report two novel susceptibility loci, one of which is a known risk allele for age-related macular degeneration.
The recently emerged pachychoroid concept has changed the understanding of age-related macular degeneration (AMD), which is a major cause of blindness; recent studies attributed AMD in part to pachychoroid disease central serous chorioretinopathy (CSC), suggesting the importance of elucidating the CSC pathogenesis. Our large genome-wide association study followed by validation studies in three independent Japanese and European cohorts, consisting of 1546 CSC samples and 13,029 controls, identified two novel CSC susceptibility loci: TNFRSF10A-LOC389641 and near GATA5 (rs13278062, odds ratio = 1.35, P = 1.26 × 10-13; rs6061548, odds ratio = 1.63, P = 5.36 × 10-15). A T allele at TNFRSF10A-LOC389641 rs13278062, a risk allele for CSC, is known to be a risk allele for AMD. This study not only identified new susceptibility genes for CSC, but also improves the understanding of the pathogenesis of AMD.
The recently emerged pachychoroid concept has changed the understanding of age-related macular degeneration (AMD), which is a major cause of blindness; recent studies attributed AMD in part to pachychoroid disease central serous chorioretinopathy (CSC), suggesting the importance of elucidating the CSC pathogenesis. Our large genome-wide association study followed by validation studies in three independent Japanese and European cohorts, consisting of 1546 CSC samples and 13,029 controls, identified two novel CSC susceptibility loci: and near (rs13278062, odds ratio = 1.35,  = 1.26 × 10 ; rs6061548, odds ratio = 1.63,  = 5.36 × 10 ). A T allele at rs13278062, a risk allele for CSC, is known to be a risk allele for AMD. This study not only identified new susceptibility genes for CSC, but also improves the understanding of the pathogenesis of AMD.
The recently emerged pachychoroid concept has changed the understanding of age-related macular degeneration (AMD), which is a major cause of blindness; recent studies attributed AMD in part to pachychoroid disease central serous chorioretinopathy (CSC), suggesting the importance of elucidating the CSC pathogenesis. Our large genome-wide association study followed by validation studies in three independent Japanese and European cohorts, consisting of 1546 CSC samples and 13,029 controls, identified two novel CSC susceptibility loci: TNFRSF10A-LOC389641 and near GATA5 (rs13278062, odds ratio = 1.35, P  = 1.26 × 10 −13 ; rs6061548, odds ratio = 1.63, P  = 5.36 × 10 −15 ). A T allele at TNFRSF10A-LOC389641 rs13278062, a risk allele for CSC, is known to be a risk allele for AMD. This study not only identified new susceptibility genes for CSC, but also improves the understanding of the pathogenesis of AMD.
The recently emerged pachychoroid concept has changed the understanding of age-related macular degeneration (AMD), which is a major cause of blindness; recent studies attributed AMD in part to pachychoroid disease central serous chorioretinopathy (CSC), suggesting the importance of elucidating the CSC pathogenesis. Our large genome-wide association study followed by validation studies in three independent Japanese and European cohorts, consisting of 1546 CSC samples and 13,029 controls, identified two novel CSC susceptibility loci: TNFRSF10A-LOC389641 and near GATA5 (rs13278062, odds ratio = 1.35, P = 1.26 × 10−13; rs6061548, odds ratio = 1.63, P = 5.36 × 10−15). A T allele at TNFRSF10A-LOC389641 rs13278062, a risk allele for CSC, is known to be a risk allele for AMD. This study not only identified new susceptibility genes for CSC, but also improves the understanding of the pathogenesis of AMD.Yoshikatsu Hosoda et al. present a genome-wide association study in Japanese and European cohorts, identifying genes related to central serous chorioretinopathy pathogenesis. They report two novel susceptibility loci, one of which is a known risk allele for age-related macular degeneration.
ArticleNumber 468
Author Tamura, Hiroshi
Ueda-Arakawa, Naoko
Nakanishi, Hideo
Boon, Camiel J. F.
Sakurada, Yoichi
Matsuda, Fumihiko
Ooto, Sotaro
Oishi, Akio
Takasago, Yukari
Iida, Tomohiro
Hosoda, Yoshikatsu
Sato, Takehiro
Shiragami, Chieko
Khor, Chiea Chuen
Miki, Akiko
Yoneyama, Seigo
Yamada, Ryo
Hata, Masayuki
Tsujikawa, Akitaka
Uji, Akihito
Takahashi, Ayako
Miyata, Manabu
Miyake, Masahiro
Hollander, Anneke I. den
Honda, Shigeru
Schellevis, Rosa L.
Muraoka, Yuki
Meguro, Akira
Mizuki, Nobuhisa
Yamashiro, Kenji
Hoyng, Carel B.
de Jong, Eiko K.
Tajima, Atsushi
Wong, Tien Yin
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  organization: Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31872073$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1101/gad.13.22.2983
10.1016/j.ophtha.2003.09.024
10.1038/ng.3226
10.1038/ng.938
10.1097/IAE.0b013e3182680a66
10.1097/IAE.0000000000000287
10.1017/thg.2016.100
10.1016/j.ajo.2018.07.004
10.1001/jamaophthalmol.2018.3190
10.1007/s00439-016-1687-1
10.1016/j.ajo.2018.06.009
10.1167/iovs.18-25497
10.1016/j.ophtha.2018.12.048
10.1073/pnas.1802212115
10.1016/j.survophthal.2012.07.004
10.1097/00006982-198700720-00009
10.1111/aos.13221
10.1016/j.ophtha.2014.09.026
10.1167/iovs.13-12867
10.1016/j.ijcard.2012.09.039
10.1007/s40123-018-0159-1
10.1034/j.1600-0420.2001.079004417.x
10.1038/ncomms9018
10.1016/S0039-6257(02)00338-7
10.1371/journal.pone.0100924
10.1007/s00417-016-3419-6
10.1111/j.1440-169X.2005.00816.x
10.1016/j.preteyeres.2015.05.003
10.1038/eye.2010.130
10.2188/jea.JE20150268
10.1038/ng.3448
10.1097/IAE.0000000000000331
10.1038/s41433-018-0158-4
10.4291/wjgp.v5.i3.355
10.1016/S0161-6420(96)30386-2
10.1167/iovs.16-20967
10.1038/ng.2578
10.1167/iovs.15-17343
10.2147/OPTH.S115685
10.1016/S0012-1606(03)00385-3
10.1016/S0161-6420(95)30960-8
10.1371/journal.pone.0025985
10.1111/j.1600-0420.2007.00889.x
10.3748/wjg.v16.i10.1201
10.1159/000050855
10.1038/ncomms9835
10.1007/s10792-017-0666-4
10.1016/j.ophtha.2007.02.032
10.1016/j.oret.2018.06.014
10.1126/science.1109557
10.1038/jhg.2016.12
10.1016/j.ophtha.2013.11.020
10.1038/srep16204
10.1038/hgv.2015.50
10.1016/B978-0-12-805313-3.00010-7
10.1097/IAE.0000000000002333
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Issue 1
Keywords Retinal diseases
Genome-wide association studies
Language English
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References Weenink, Borsje, Oosterhuis (CR11) 2001; 215
Bagheri, Rashe, Ahoor, Somi (CR13) 2017; 6
Stennard (CR44) 2003; 262
Gemenetzi, De Salvo, Lotery (CR1) 2010; 24
De Jong (CR29) 2015; 122
CR33
Cakir (CR47) 2019
Wang (CR15) 2008; 86
Cheung (CR22) 2019; 33
Bouzas, Karadimas, Pournaras (CR42) 2002; 47
Fukuda, Yasugi (CR51) 2005; 6
Kitzmann, Pulido, Diehl, Hodge, Burke (CR2) 2008; 115
Fritsche (CR37) 2013; 45
Bujarborua (CR4) 2001; 79
Spaide (CR16) 1996; 103
Breukink (CR34) 2015; 56
Kuriyama (CR54) 2016; 26
Mishra, MacGregor (CR35) 2017; 20
Daruich (CR8) 2015; 48
Yamaguchi-Kabata (CR55) 2015; 2
Azar (CR21) 2017; 95
Cheung (CR40) 2018; 2
Narahara (CR57) 2014; 9
Akkaya (CR25) 2017; 38
Sobota (CR50) 2016; 8
Reiter (CR45) 1999; 13
Higasa (CR58) 2016; 61
Miki (CR31) 2018; 59
Sun (CR38) 2013; 54
Klein, Robert, Emily, Tsai (CR26) 2005; 308
Pang, Freund (CR17) 2015; 35
Schellevis (CR30) 2018
Fritsche (CR39) 2016; 48
Nagasaki (CR56) 2015; 6
Nicholson, Noble, Forooghian, Meyerle (CR3) 2013; 58
Gass, Little (CR41) 1995; 102
Breukink (CR5) 2016; 11
Hata (CR24) 2017; 58
Miki (CR27) 2014; 121
Aung (CR53) 2015; 47
Rochepeau (CR48) 2018; 194
Mrejen (CR6) 2019
Fung, Yannuzzi, Bailey Freund (CR20) 2012; 32
Lehmann, Bousquet, Beydoun, Behar-Cohen (CR18) 2015; 35
Shiragami (CR7) 2018; 193
Arakawa (CR36) 2011; 43
Dijk (CR32) 2017; 135
Mateo-Montoya, Mauget-Faÿse (CR12) 2014; 5
Jiang (CR43) 2013; 165
Yannuzzi (CR9) 1987; 7:2
CR23
Zavoloka (CR14) 2016; 254
Miyake (CR19) 2015; 5
Wen (CR52) 2010; 16
Messaoudi (CR46) 2015; 6
Wang (CR49) 2011
Hosoda (CR28) 2018; 115
Haimovici, Koh, Gagnon, Lehrfeld, Wellik (CR10) 2004; 111
CMG Cheung (712_CR22) 2019; 33
Sezen Akkaya (712_CR25) 2017; 38
C Rochepeau (712_CR48) 2018; 194
K Higasa (712_CR58) 2016; 61
M Bagheri (712_CR13) 2017; 6
T Aung (712_CR53) 2015; 47
A Mishra (712_CR35) 2017; 20
Y Yamaguchi-Kabata (712_CR55) 2015; 2
RS Sobota (712_CR50) 2016; 8
L Yannuzzi (712_CR9) 1987; 7:2
A Miki (712_CR31) 2018; 59
EK De Jong (712_CR29) 2015; 122
712_CR23
O Zavoloka (712_CR14) 2016; 254
M Hata (712_CR24) 2017; 58
LG Fritsche (712_CR37) 2013; 45
B Nicholson (712_CR3) 2013; 58
M Lehmann (712_CR18) 2015; 35
D Bujarborua (712_CR4) 2001; 79
R Haimovici (712_CR10) 2004; 111
XZ Wen (712_CR52) 2010; 16
LG Fritsche (712_CR39) 2016; 48
J-Q Jiang (712_CR43) 2013; 165
A Mateo-Montoya (712_CR12) 2014; 5
A Miki (712_CR27) 2014; 121
712_CR33
FA Stennard (712_CR44) 2003; 262
C Shiragami (712_CR7) 2018; 193
K Fukuda (712_CR51) 2005; 6
X Wang (712_CR49) 2011
Y Sun (712_CR38) 2013; 54
JF Reiter (712_CR45) 1999; 13
E Dijk (712_CR32) 2017; 135
M Nagasaki (712_CR56) 2015; 6
MB Breukink (712_CR5) 2016; 11
A Daruich (712_CR8) 2015; 48
M Wang (712_CR15) 2008; 86
AAC Weenink (712_CR11) 2001; 215
M Gemenetzi (712_CR1) 2010; 24
RF Spaide (712_CR16) 1996; 103
S Messaoudi (712_CR46) 2015; 6
AT Fung (712_CR20) 2012; 32
RL Schellevis (712_CR30) 2018
S Kuriyama (712_CR54) 2016; 26
RJ Klein (712_CR26) 2005; 308
MB Breukink (712_CR34) 2015; 56
M Narahara (712_CR57) 2014; 9
G Azar (712_CR21) 2017; 95
S Mrejen (712_CR6) 2019
CE Pang (712_CR17) 2015; 35
AS Kitzmann (712_CR2) 2008; 115
JDM Gass (712_CR41) 1995; 102
EA Bouzas (712_CR42) 2002; 47
B Cakir (712_CR47) 2019
S Arakawa (712_CR36) 2011; 43
Y Hosoda (712_CR28) 2018; 115
CMG Cheung (712_CR40) 2018; 2
M Miyake (712_CR19) 2015; 5
References_xml – volume: 13
  start-page: 2983
  year: 1999
  end-page: 2995
  ident: CR45
  article-title: Gata5 is required for the development of the heart and endoderm in zebrafish
  publication-title: Genes Dev.
  doi: 10.1101/gad.13.22.2983
– volume: 111
  start-page: 244
  year: 2004
  end-page: 249
  ident: CR10
  article-title: Risk factors for central serous chorioretinopathy: a case-control study
  publication-title: Ophthalmology
  doi: 10.1016/j.ophtha.2003.09.024
– volume: 47
  start-page: 387
  issue: Apr
  year: 2015
  end-page: 392
  ident: CR53
  article-title: A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3226
– volume: 43
  start-page: 1001
  year: 2011
  end-page: 1005
  ident: CR36
  article-title: Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population
  publication-title: Nat. Genet.
  doi: 10.1038/ng.938
– volume: 32
  start-page: 1829
  year: 2012
  end-page: 1837
  ident: CR20
  article-title: Type 1 (Sub-retinal pigment epithelial) neovascularization in central serous chorioretinopathy masquerading as neovascular age-related macular degeneration
  publication-title: Retina
  doi: 10.1097/IAE.0b013e3182680a66
– volume: 35
  start-page: 10
  year: 2015
  end-page: 16
  ident: CR18
  article-title: Pachychoroid: an inherited condition?
  publication-title: Retina
  doi: 10.1097/IAE.0000000000000287
– volume: 20
  start-page: 1
  year: 2017
  end-page: 9
  ident: CR35
  article-title: A novel approach for pathway analysis of GWAS data highlights role of BMP signaling and muscle cell differentiation in colorectal cancer susceptibility
  publication-title: Twin Res. Hum. Genet.
  doi: 10.1017/thg.2016.100
– volume: 194
  start-page: 26
  year: 2018
  end-page: 34
  ident: CR48
  article-title: Optical coherence tomography angiography quantitative assessment of choriocapillaris blood flow in central serous chorioretinopathy
  publication-title: Am. J. Ophthalmol.
  doi: 10.1016/j.ajo.2018.07.004
– year: 2018
  ident: CR30
  article-title: Role of the complement system in chronic central serous chorioretinopathy: a genome-wide association study
  publication-title: JAMA Ophthalmol.
  doi: 10.1001/jamaophthalmol.2018.3190
– volume: 8
  start-page: 895
  year: 2016
  end-page: 906
  ident: CR50
  article-title: Epigenetic and genetic variation in GATA5 is associated with gastric disease risk
  publication-title: Hum. Genet.
  doi: 10.1007/s00439-016-1687-1
– volume: 193
  start-page: 80
  year: 2018
  end-page: 86
  ident: CR7
  article-title: Clinical features of central serous chorioretinopathy with Type 1 choroidal neovascularization
  publication-title: Am. J. Ophthalmol.
  doi: 10.1016/j.ajo.2018.06.009
– volume: 59
  start-page: 5542
  year: 2018
  ident: CR31
  article-title: Genome-wide association study to identify a new susceptibility locus for central serous chorioretinopathy in the Japanese population
  publication-title: Investig. Opthalmol. Vis. Sci.
  doi: 10.1167/iovs.18-25497
– year: 2019
  ident: CR6
  article-title: Long-term visual outcomes and causes of vision loss in chronic central serous chorioretinopathy
  publication-title: Ophthalmology
  doi: 10.1016/j.ophtha.2018.12.048
– volume: 115
  start-page: 6261
  year: 2018
  end-page: 6266
  ident: CR28
  article-title: CFH and VIPR2 as susceptibility loci in choroidal thickness and pachychoroid disease central serous chorioretinopathy
  publication-title: Proc. Natl Acad. Sci. U.S.A.
  doi: 10.1073/pnas.1802212115
– volume: 58
  start-page: 103
  year: 2013
  end-page: 126
  ident: CR3
  article-title: Central serous chorioretinopathy: update on pathophysiology and treatment
  publication-title: Surv. Ophthalmol.
  doi: 10.1016/j.survophthal.2012.07.004
– volume: 7:2
  start-page: 111
  year: 1987
  end-page: 131
  ident: CR9
  article-title: Type-A behavior and central serous chorioretinopathy
  publication-title: Retina
  doi: 10.1097/00006982-198700720-00009
– volume: 95
  start-page: 421
  year: 2017
  end-page: 427
  ident: CR21
  article-title: Pachychoroid neovasculopathy: aspect on optical coherence tomography angiography
  publication-title: Acta Ophthalmol.
  doi: 10.1111/aos.13221
– volume: 122
  start-page: 562
  year: 2015
  end-page: 570
  ident: CR29
  article-title: Chronic central serous chorioretinopathy is associated with genetic variants implicated in age-related macular degeneration
  publication-title: Ophthalmology
  doi: 10.1016/j.ophtha.2014.09.026
– volume: 54
  start-page: 8199
  year: 2013
  end-page: 8203
  ident: CR38
  article-title: TNFRSF10A-LOC389641 rs13278062 but not REST-C4orf14-POLR2B-IGFBP7 rs1713985 was found associated with age-related macular degeneration in a Chinese population
  publication-title: Invest. Ophthalmol. Vis. Sci.
  doi: 10.1167/iovs.13-12867
– volume: 165
  start-page: 570
  year: 2013
  end-page: 573
  ident: CR43
  article-title: Prevalence and spectrum of GATA5 mutations associated with congenital heart disease
  publication-title: Int. J. Cardiol.
  doi: 10.1016/j.ijcard.2012.09.039
– year: 2019
  ident: CR47
  article-title: OCT Angiography of the choriocapillaris in central serous chorioretinopathy: a quantitative subgroup analysis
  publication-title: Ophthalmol. Ther.
  doi: 10.1007/s40123-018-0159-1
– volume: 79
  start-page: 417
  year: 2001
  end-page: 421
  ident: CR4
  article-title: Long-term follow-up of idiopathic central serous chorioretinopathy without laser
  publication-title: Acta Ophthalmol. Scand.
  doi: 10.1034/j.1600-0420.2001.079004417.x
– volume: 6
  year: 2015
  ident: CR56
  article-title: Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms9018
– volume: 47
  start-page: 431
  year: 2002
  end-page: 448
  ident: CR42
  article-title: Central serous chorioretinopathy and glucocorticoids
  publication-title: Surv. Ophthalmol.
  doi: 10.1016/S0039-6257(02)00338-7
– volume: 9
  start-page: e100924
  year: 2014
  ident: CR57
  article-title: Large-scale East-Asian eQTL mapping reveals novel candidate genes for LD mapping and the genomic landscape of transcriptional effects of sequence variants
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0100924
– volume: 254
  start-page: 2071
  year: 2016
  ident: CR14
  article-title: Helicobacter pylori is the culprit behind central serous chorioretinopathy. Graefe’s Arch
  publication-title: Clin. Exp. Ophthalmol.
  doi: 10.1007/s00417-016-3419-6
– volume: 6
  start-page: 375
  year: 2005
  end-page: 382
  ident: CR51
  article-title: The molecular mechanisms of stomach development in vertebrates
  publication-title: Dev. Growth Differ.
  doi: 10.1111/j.1440-169X.2005.00816.x
– volume: 48
  start-page: 82
  year: 2015
  end-page: 118
  ident: CR8
  article-title: Central serous chorioretinopathy: recent findings and new physiopathology hypothesis
  publication-title: Prog. Retin. Eye Res.
  doi: 10.1016/j.preteyeres.2015.05.003
– volume: 24
  start-page: 1743
  year: 2010
  end-page: 1756
  ident: CR1
  article-title: Central serous chorioretinopathy: an update on pathogenesis and treatment
  publication-title: Eye
  doi: 10.1038/eye.2010.130
– ident: CR33
– volume: 26
  start-page: 493
  year: 2016
  end-page: 511
  ident: CR54
  article-title: The Tohoku medical megabank project: design and mission
  publication-title: J. Epidemiol.
  doi: 10.2188/jea.JE20150268
– volume: 48
  start-page: 134
  year: 2016
  end-page: 143
  ident: CR39
  article-title: A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3448
– volume: 35
  start-page: 1
  year: 2015
  end-page: 9
  ident: CR17
  article-title: Pachychoroid neovasculopathy
  publication-title: Retina
  doi: 10.1097/IAE.0000000000000331
– volume: 33
  start-page: 14
  year: 2019
  end-page: 33
  ident: CR22
  article-title: Pachychoroid disease
  publication-title: Eye
  doi: 10.1038/s41433-018-0158-4
– volume: 5
  start-page: 355
  year: 2014
  end-page: 358
  ident: CR12
  article-title: Helicobacter pylori as a risk factor for central serous chorioretinopathy: literature review
  publication-title: World J. Gastrointest. Pathophysiol.
  doi: 10.4291/wjgp.v5.i3.355
– volume: 103
  start-page: 2070
  year: 1996
  end-page: 2080
  ident: CR16
  article-title: Central serous chorioretinopathy in younger and older adults
  publication-title: Ophthalmology
  doi: 10.1016/S0161-6420(96)30386-2
– volume: 58
  start-page: 292
  year: 2017
  end-page: 298
  ident: CR24
  article-title: Intraocular vascular endothelial growth factor levels in pachychoroid neovasculopathy and neovascular age- related macular degeneration
  publication-title: Investig. Ophthalmol. Vis. Sci.
  doi: 10.1167/iovs.16-20967
– volume: 45
  start-page: 433
  year: 2013
  end-page: 439
  ident: CR37
  article-title: Seven new loci associated with age-related macular degeneration
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2578
– volume: 56
  start-page: 5608
  year: 2015
  end-page: 5613
  ident: CR34
  article-title: Genomic copy number variations of the complement component C4B Ggene are associated with chronic central serous chorioretinopathy
  publication-title: Invest. Ophthalmol. Vis. Sci.
  doi: 10.1167/iovs.15-17343
– volume: 11
  start-page: 39
  year: 2016
  end-page: 46
  ident: CR5
  article-title: Chronic central serous chorioretinopathy: long-term follow-up and vision-related quality of life
  publication-title: Clin. Ophthalmol.
  doi: 10.2147/OPTH.S115685
– ident: CR23
– volume: 262
  start-page: 206
  year: 2003
  end-page: 224
  ident: CR44
  article-title: Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart
  publication-title: Dev. Biol.
  doi: 10.1016/S0012-1606(03)00385-3
– volume: 102
  start-page: 737
  year: 1995
  end-page: 747
  ident: CR41
  article-title: Bilateral bullous exudative retinal detachment complicating idiopathic central serous chorioretinopathy during systemic corticosteroid therapy
  publication-title: Ophthalmology
  doi: 10.1016/S0161-6420(95)30960-8
– year: 2011
  ident: CR49
  article-title: Epigenetic subgroups of esophageal and gastric adenocarcinoma with differential GATA5 DNA methylation associated with clinical and lifestyle factors
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0025985
– volume: 86
  start-page: 126
  year: 2008
  end-page: 145
  ident: CR15
  article-title: Central serous chorioretinopathy
  publication-title: Acta Ophthalmol.
  doi: 10.1111/j.1600-0420.2007.00889.x
– volume: 16
  start-page: 1201
  year: 2010
  end-page: 1208
  ident: CR52
  article-title: Methylation of GATA-4 and GATA-5 and development of sporadic gastric carcinomas
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v16.i10.1201
– volume: 215
  start-page: 183
  year: 2001
  end-page: 187
  ident: CR11
  article-title: Familial chronic central serous chorioretinopathy
  publication-title: Ophthalmologica
  doi: 10.1159/000050855
– volume: 6
  year: 2015
  ident: CR46
  article-title: Endothelial Gata5 transcription factor regulates blood pressure
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms9835
– volume: 38
  start-page: 2239
  issue: 5
  year: 2017
  end-page: 2246
  ident: CR25
  article-title: Spectrum of pachychoroid diseases
  publication-title: International Ophthalmology
  doi: 10.1007/s10792-017-0666-4
– volume: 115
  start-page: 169
  year: 2008
  end-page: 173
  ident: CR2
  article-title: The incidence of central serous chorioretinopathy in Olmsted county, Minnesota, 1980-2002
  publication-title: Ophthalmology
  doi: 10.1016/j.ophtha.2007.02.032
– volume: 135
  start-page: 446
  year: 2017
  end-page: 451
  ident: CR32
  article-title: Association of a haplotype in the NR3C2 gene, encoding the mineralocorticoid receptor, with chronic central serous chorioretinopathy
  publication-title: Ophthalmology
– volume: 2
  start-page: 1196
  year: 2018
  end-page: 1205
  ident: CR40
  article-title: Association between choroidal thickness and drusen subtypes in age-related macular degeneration
  publication-title: Ophthalmol. Retin.
  doi: 10.1016/j.oret.2018.06.014
– volume: 308
  start-page: 385
  year: 2005
  end-page: 389
  ident: CR26
  article-title: Complement factor H polymorphism in age-related macular degeneration
  publication-title: Sci. (80−.).
  doi: 10.1126/science.1109557
– volume: 61
  start-page: 547
  year: 2016
  end-page: 553
  ident: CR58
  article-title: Human genetic variation database, a reference database of genetic variations in the Japanese population
  publication-title: J. Hum. Genet.
  doi: 10.1038/jhg.2016.12
– volume: 6
  start-page: 118
  year: 2017
  end-page: 124
  ident: CR13
  article-title: Prevalence of Helicobacter pylori infection in patients with central serous chorioretinopathy: a review
  publication-title: Med. hypothesis, Discov. Innov. Ophthalmol. J.
– volume: 121
  start-page: 1067
  year: 2014
  end-page: 1072
  ident: CR27
  article-title: Common variants in the complement factor H gene confer genetic susceptibility to central serous chorioretinopathy
  publication-title: Ophthalmology
  doi: 10.1016/j.ophtha.2013.11.020
– volume: 5
  year: 2015
  ident: CR19
  article-title: Pachychoroid neovasculopathy and age-related macular degeneration
  publication-title: Sci. Rep.
  doi: 10.1038/srep16204
– volume: 2
  start-page: 15050
  year: 2015
  ident: CR55
  article-title: iJGVD: an integrative Japanese genome variation database based on whole-genome sequencing
  publication-title: Hum. Genome Var.
  doi: 10.1038/hgv.2015.50
– volume: 6
  year: 2015
  ident: 712_CR56
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms9018
– volume: 35
  start-page: 10
  year: 2015
  ident: 712_CR18
  publication-title: Retina
  doi: 10.1097/IAE.0000000000000287
– volume: 102
  start-page: 737
  year: 1995
  ident: 712_CR41
  publication-title: Ophthalmology
  doi: 10.1016/S0161-6420(95)30960-8
– volume: 45
  start-page: 433
  year: 2013
  ident: 712_CR37
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2578
– volume: 8
  start-page: 895
  year: 2016
  ident: 712_CR50
  publication-title: Hum. Genet.
  doi: 10.1007/s00439-016-1687-1
– volume: 47
  start-page: 387
  issue: Apr
  year: 2015
  ident: 712_CR53
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3226
– volume: 47
  start-page: 431
  year: 2002
  ident: 712_CR42
  publication-title: Surv. Ophthalmol.
  doi: 10.1016/S0039-6257(02)00338-7
– volume: 2
  start-page: 15050
  year: 2015
  ident: 712_CR55
  publication-title: Hum. Genome Var.
  doi: 10.1038/hgv.2015.50
– volume: 32
  start-page: 1829
  year: 2012
  ident: 712_CR20
  publication-title: Retina
  doi: 10.1097/IAE.0b013e3182680a66
– volume: 33
  start-page: 14
  year: 2019
  ident: 712_CR22
  publication-title: Eye
  doi: 10.1038/s41433-018-0158-4
– volume: 262
  start-page: 206
  year: 2003
  ident: 712_CR44
  publication-title: Dev. Biol.
  doi: 10.1016/S0012-1606(03)00385-3
– volume: 2
  start-page: 1196
  year: 2018
  ident: 712_CR40
  publication-title: Ophthalmol. Retin.
  doi: 10.1016/j.oret.2018.06.014
– volume: 35
  start-page: 1
  year: 2015
  ident: 712_CR17
  publication-title: Retina
  doi: 10.1097/IAE.0000000000000331
– volume: 79
  start-page: 417
  year: 2001
  ident: 712_CR4
  publication-title: Acta Ophthalmol. Scand.
  doi: 10.1034/j.1600-0420.2001.079004417.x
– volume: 308
  start-page: 385
  year: 2005
  ident: 712_CR26
  publication-title: Sci. (80−.).
  doi: 10.1126/science.1109557
– volume: 6
  start-page: 375
  year: 2005
  ident: 712_CR51
  publication-title: Dev. Growth Differ.
  doi: 10.1111/j.1440-169X.2005.00816.x
– year: 2018
  ident: 712_CR30
  publication-title: JAMA Ophthalmol.
  doi: 10.1001/jamaophthalmol.2018.3190
– volume: 56
  start-page: 5608
  year: 2015
  ident: 712_CR34
  publication-title: Invest. Ophthalmol. Vis. Sci.
  doi: 10.1167/iovs.15-17343
– volume: 13
  start-page: 2983
  year: 1999
  ident: 712_CR45
  publication-title: Genes Dev.
  doi: 10.1101/gad.13.22.2983
– ident: 712_CR23
  doi: 10.1016/B978-0-12-805313-3.00010-7
– volume: 26
  start-page: 493
  year: 2016
  ident: 712_CR54
  publication-title: J. Epidemiol.
  doi: 10.2188/jea.JE20150268
– volume: 5
  start-page: 355
  year: 2014
  ident: 712_CR12
  publication-title: World J. Gastrointest. Pathophysiol.
  doi: 10.4291/wjgp.v5.i3.355
– volume: 11
  start-page: 39
  year: 2016
  ident: 712_CR5
  publication-title: Clin. Ophthalmol.
  doi: 10.2147/OPTH.S115685
– volume: 61
  start-page: 547
  year: 2016
  ident: 712_CR58
  publication-title: J. Hum. Genet.
  doi: 10.1038/jhg.2016.12
– volume: 86
  start-page: 126
  year: 2008
  ident: 712_CR15
  publication-title: Acta Ophthalmol.
  doi: 10.1111/j.1600-0420.2007.00889.x
– volume: 48
  start-page: 82
  year: 2015
  ident: 712_CR8
  publication-title: Prog. Retin. Eye Res.
  doi: 10.1016/j.preteyeres.2015.05.003
– year: 2011
  ident: 712_CR49
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0025985
– volume: 122
  start-page: 562
  year: 2015
  ident: 712_CR29
  publication-title: Ophthalmology
  doi: 10.1016/j.ophtha.2014.09.026
– ident: 712_CR33
  doi: 10.1097/IAE.0000000000002333
– volume: 54
  start-page: 8199
  year: 2013
  ident: 712_CR38
  publication-title: Invest. Ophthalmol. Vis. Sci.
  doi: 10.1167/iovs.13-12867
– volume: 95
  start-page: 421
  year: 2017
  ident: 712_CR21
  publication-title: Acta Ophthalmol.
  doi: 10.1111/aos.13221
– volume: 24
  start-page: 1743
  year: 2010
  ident: 712_CR1
  publication-title: Eye
  doi: 10.1038/eye.2010.130
– volume: 6
  start-page: 118
  year: 2017
  ident: 712_CR13
  publication-title: Med. hypothesis, Discov. Innov. Ophthalmol. J.
– volume: 16
  start-page: 1201
  year: 2010
  ident: 712_CR52
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v16.i10.1201
– volume: 58
  start-page: 292
  year: 2017
  ident: 712_CR24
  publication-title: Investig. Ophthalmol. Vis. Sci.
  doi: 10.1167/iovs.16-20967
– volume: 111
  start-page: 244
  year: 2004
  ident: 712_CR10
  publication-title: Ophthalmology
  doi: 10.1016/j.ophtha.2003.09.024
– year: 2019
  ident: 712_CR47
  publication-title: Ophthalmol. Ther.
  doi: 10.1007/s40123-018-0159-1
– volume: 103
  start-page: 2070
  year: 1996
  ident: 712_CR16
  publication-title: Ophthalmology
  doi: 10.1016/S0161-6420(96)30386-2
– volume: 38
  start-page: 2239
  issue: 5
  year: 2017
  ident: 712_CR25
  publication-title: International Ophthalmology
  doi: 10.1007/s10792-017-0666-4
– volume: 9
  start-page: e100924
  year: 2014
  ident: 712_CR57
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0100924
– volume: 165
  start-page: 570
  year: 2013
  ident: 712_CR43
  publication-title: Int. J. Cardiol.
  doi: 10.1016/j.ijcard.2012.09.039
– volume: 20
  start-page: 1
  year: 2017
  ident: 712_CR35
  publication-title: Twin Res. Hum. Genet.
  doi: 10.1017/thg.2016.100
– volume: 59
  start-page: 5542
  year: 2018
  ident: 712_CR31
  publication-title: Investig. Opthalmol. Vis. Sci.
  doi: 10.1167/iovs.18-25497
– volume: 6
  year: 2015
  ident: 712_CR46
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms9835
– volume: 193
  start-page: 80
  year: 2018
  ident: 712_CR7
  publication-title: Am. J. Ophthalmol.
  doi: 10.1016/j.ajo.2018.06.009
– volume: 5
  year: 2015
  ident: 712_CR19
  publication-title: Sci. Rep.
  doi: 10.1038/srep16204
– volume: 115
  start-page: 6261
  year: 2018
  ident: 712_CR28
  publication-title: Proc. Natl Acad. Sci. U.S.A.
  doi: 10.1073/pnas.1802212115
– volume: 135
  start-page: 446
  year: 2017
  ident: 712_CR32
  publication-title: Ophthalmology
– volume: 48
  start-page: 134
  year: 2016
  ident: 712_CR39
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3448
– year: 2019
  ident: 712_CR6
  publication-title: Ophthalmology
  doi: 10.1016/j.ophtha.2018.12.048
– volume: 58
  start-page: 103
  year: 2013
  ident: 712_CR3
  publication-title: Surv. Ophthalmol.
  doi: 10.1016/j.survophthal.2012.07.004
– volume: 254
  start-page: 2071
  year: 2016
  ident: 712_CR14
  publication-title: Clin. Exp. Ophthalmol.
  doi: 10.1007/s00417-016-3419-6
– volume: 43
  start-page: 1001
  year: 2011
  ident: 712_CR36
  publication-title: Nat. Genet.
  doi: 10.1038/ng.938
– volume: 115
  start-page: 169
  year: 2008
  ident: 712_CR2
  publication-title: Ophthalmology
  doi: 10.1016/j.ophtha.2007.02.032
– volume: 194
  start-page: 26
  year: 2018
  ident: 712_CR48
  publication-title: Am. J. Ophthalmol.
  doi: 10.1016/j.ajo.2018.07.004
– volume: 215
  start-page: 183
  year: 2001
  ident: 712_CR11
  publication-title: Ophthalmologica
  doi: 10.1159/000050855
– volume: 121
  start-page: 1067
  year: 2014
  ident: 712_CR27
  publication-title: Ophthalmology
  doi: 10.1016/j.ophtha.2013.11.020
– volume: 7:2
  start-page: 111
  year: 1987
  ident: 712_CR9
  publication-title: Retina
  doi: 10.1097/00006982-198700720-00009
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Snippet The recently emerged pachychoroid concept has changed the understanding of age-related macular degeneration (AMD), which is a major cause of blindness; recent...
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SubjectTerms 45/43
631/208/205/2138
692/699/3161/3175
Age
Alleles
Biology
Biomedical and Life Sciences
Blindness
Case-Control Studies
Central Serous Chorioretinopathy - epidemiology
Central Serous Chorioretinopathy - genetics
Computational Biology - methods
Databases, Genetic
Europe - epidemiology
Female
Gene Expression
Genetic Loci
Genetic Predisposition to Disease
Genome-wide association studies
Genome-Wide Association Study
Genomes
Humans
Life Sciences
Macular degeneration
Male
Odds Ratio
Pathogenesis
Quantitative Trait Loci
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Title Genome-wide association analyses identify two susceptibility loci for pachychoroid disease central serous chorioretinopathy
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