MICA polymorphisms and decreased expression of the MICA receptor NKG2D contribute to idiopathic pulmonary fibrosis susceptibility

• Published in: Human genetics Vol. 125; no. 5-6; pp. 639 - 648
• Main Authors: Aquino-Galvez, Arnoldo, Pérez-Rodríguez, Martha, Camarena, Ángel, Falfan-Valencia, Ramces, Ruiz, Víctor, Montaño, Martha, Barrera, Lourdes, Sada-Ovalle, Isabel, Ramírez, Remedios, Granados, Julio, Pardo, Annie, Selman, Moisés
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.06.2009; Springer-Verlag; Springer; Springer Nature B.V
• Subjects: Adult; Aged; Analysis; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Biopsy; Case-Control Studies; Cell receptors; Cell structures and functions; Cells, Cultured; Classical genetics, quantitative genetics, hybrids; Development and progression; Enzyme-linked immunosorbent assay; Female; Fundamental and applied biological sciences. Psychology; Gene Expression; Gene Frequency; Gene Function; Genetic aspects; Genetic polymorphisms; Genetic Predisposition to Disease; Genetics of eukaryotes. Biological and molecular evolution; Genotype; Histocompatibility Antigens Class I - blood; Histocompatibility Antigens Class I - genetics; HLA-B Antigens - genetics; Human; Human Genetics; Humans; Idiopathic Pulmonary Fibrosis - genetics; Killer cells; Killer Cells, Natural - metabolism; Lung - metabolism; Lung diseases; Lungs; Lymphocytes; Male; Medical sciences; Metabolic Diseases; Middle Aged; Miscellaneous; Molecular and cellular biology; Molecular Medicine; NK Cell Lectin-Like Receptor Subfamily K - genetics; NK Cell Lectin-Like Receptor Subfamily K - metabolism; Original Investigation; Pneumology; Polymorphism, Genetic; Proteins; Pulmonary fibrosis; Respiratory system : syndromes and miscellaneous diseases; Risk factors; Sequence Analysis, DNA; Society; T cells; T-Lymphocyte Subsets - metabolism; Mexico; Idiopathic Pulmonary Fibrosis; Major Histocompatibility Complex; Hypersensitivity Pneumonitis; Idiopathic Pulmonary Fibrosis Patient; Alveolar Epithelial Cell; Lung disease; Pulmonary fibrosis; Respiratory disease; Idiopathic; MICA ligand; Genetics; Polymorphism; Biological receptor

Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disorder of unknown etiology. IPF is likely the result of complex interrelationships between environmental and host factors, although the genetic risk factors are presently uncertain. Because we have found that some MHC polymorphis...