Tafoxiparin, a novel drug candidate for cervical ripening and labor augmentation: results from 2 randomized, placebo-controlled studies

• Published in: American journal of obstetrics and gynecology Vol. 230; no. 3; pp. S759 - S768
• Main Authors: Ekman-Ordeberg, Gunvor, Hellgren-Wångdahl, Margareta, Jeppson, Annika, Rahkonen, Leena, Blomberg, Marie, Pettersson, Karin, Bejlum, Carina, Engberg, Malin, Ludvigsen, Mette, Uotila, Jukka, Tihtonen, Kati, Hallberg, Gunilla, Jonsson, Maria
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2024
• Subjects: Cervical Ripening; dystocia; Female; Heparin; Humans; infants; labor induction; labor time; Labor, Induced - methods; Medicin och hälsovetenskap; neonates; Obstetrics, Gynecology and Reproductive Medicine; Oxytocics; oxytocin; Oxytocin - therapeutic use; Pharmaceutical Preparations; Pregnancy; Randomized Controlled Trials as Topic; Reproduktionsmedicin och gynekologi; slow progress of labor; labor induction; slow progress of labor; oxytocin; infants; dystocia; neonates; labor time

Slow progression of labor is a common obstetrical problem with multiple associated complications. Tafoxiparin is a depolymerized form of heparin with a molecular structure that eliminates the anticoagulant effects of heparin. We report on 2 phase II clinical studies of tafoxiparin in primiparas. Stu...