Life Without Thyroid Hormone Receptor

• Published in: Endocrinology (Philadelphia) Vol. 162; no. 4; p. 1
• Main Author: Shi, Yun-Bo
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.04.2021
• Subjects: Amphibians; Analysis; Animals; Degeneration; Diploids; Divergence; Endocrinology; Frogs; Gene Expression Regulation, Developmental; Gene silencing; Genes; Genetic modification; Genome editing; Hormones; Humans; Lethality; Mammals; Mammals - genetics; Mammals - growth & development; Mammals - metabolism; Metabolism; Metamorphosis; Metamorphosis, Biological; Mini-Reviews; Neonates; Organs; Receptors; Receptors, Thyroid Hormone - genetics; Receptors, Thyroid Hormone - metabolism; Thyroid; Thyroid gland; Tissues; Triiodothyronine; Triiodothyronine - metabolism; Vertebrates; amphibian metamorphosis; thyroid hormone receptor; histone modification; adult stem cells; Xenopus tropicalis; Xenopus laevis

Thyroid hormone (T3) is critical not only for organ function and metabolism in the adult but also for animal development. This is particularly true during the neonatal period when T3 levels are high in mammals. Many processes during this postembryonic developmental period resemble those during amphi...