Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals

Gout is a common arthritis caused by elevated serum uric acid (SUA) levels. Here we investigated loci influencing SUA in a genome-wide meta-analysis with 121,745 Japanese subjects. We identified 8948 variants at 36 genomic loci ( P <5 × 10 –8 ) including eight novel loci. Of these, missense varia...

Full description

Saved in:
Bibliographic Details
Published inCommunications biology Vol. 2; no. 1; p. 115
Main Authors Nakatochi, Masahiro, Kanai, Masahiro, Nakayama, Akiyoshi, Hishida, Asahi, Kawamura, Yusuke, Ichihara, Sahoko, Akiyama, Masato, Ikezaki, Hiroaki, Furusyo, Norihiro, Shimizu, Seiko, Yamamoto, Ken, Hirata, Makoto, Okada, Rieko, Kawai, Sayo, Kawaguchi, Makoto, Nishida, Yuichiro, Shimanoe, Chisato, Ibusuki, Rie, Takezaki, Toshiro, Nakajima, Mayuko, Takao, Mikiya, Ozaki, Etsuko, Matsui, Daisuke, Nishiyama, Takeshi, Suzuki, Sadao, Takashima, Naoyuki, Kita, Yoshikuni, Endoh, Kaori, Kuriki, Kiyonori, Uemura, Hirokazu, Arisawa, Kokichi, Oze, Isao, Matsuo, Keitaro, Nakamura, Yohko, Mikami, Haruo, Tamura, Takashi, Nakashima, Hiroshi, Nakamura, Takahiro, Kato, Norihiro, Matsuda, Koichi, Murakami, Yoshinori, Matsubara, Tatsuaki, Naito, Mariko, Kubo, Michiaki, Kamatani, Yoichiro, Shinomiya, Nariyoshi, Yokota, Mitsuhiro, Wakai, Kenji, Okada, Yukinori, Matsuo, Hirotaka
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 08.04.2019
Nature Publishing Group
Subjects
45
45/43
631/208/205/2138
692/699/1670/3/2765/1528
Alleles
Arthritis
Biology
Biomedical and Life Sciences
Computational Biology
Gene loci
Gene regulation
Genetic Predisposition to Disease
Genome-Wide Association Study
Genomes
Genotype
Gout
Gout - blood
Gout - etiology
Gout - metabolism
Hepatocyte nuclear factor 4
Humans
Hyperuricemia
Japan
Life Sciences
Meta-analysis
Molecular Sequence Annotation
Oxidative metabolism
Oxidative stress
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Quantitative Trait, Heritable
Rheumatism
Uric acid
Uric Acid - blood
Japan
Online AccessGet full text
ISSN2399-3642
2399-3642
DOI10.1038/s42003-019-0339-0

Cover

Abstract Gout is a common arthritis caused by elevated serum uric acid (SUA) levels. Here we investigated loci influencing SUA in a genome-wide meta-analysis with 121,745 Japanese subjects. We identified 8948 variants at 36 genomic loci ( P <5 × 10 –8 ) including eight novel loci. Of these, missense variants of SESN2 and PNPLA3 were predicted to be damaging to the function of these proteins; another five loci— TMEM18 , TM4SF4 , MXD3-LMAN2 , PSORS1C1-PSORS1C2 , and HNF4A —are related to cell metabolism, proliferation, or oxidative stress; and the remaining locus, LINC01578 , is unknown. We also identified 132 correlated genes whose expression levels are associated with SUA-increasing alleles. These genes are enriched for the UniProt transport term, suggesting the importance of transport-related genes in SUA regulation. Furthermore, trans-ethnic meta-analysis across our own meta-analysis and the Global Urate Genetics Consortium has revealed 15 more novel loci associated with SUA. Our findings provide insight into the pathogenesis, treatment, and prevention of hyperuricemia/gout. Masahiro Nakatochi et al. report a genome-wide meta-analysis of serum uric acid levels in the Japanese population. They identify 36 loci, including eight previously unreported loci, suggesting key cellular processes that contribute to elevated serum uric acid levels, which can lead to gout.
AbstractList Gout is a common arthritis caused by elevated serum uric acid (SUA) levels. Here we investigated loci influencing SUA in a genome-wide meta-analysis with 121,745 Japanese subjects. We identified 8948 variants at 36 genomic loci ( P <5 × 10 –8 ) including eight novel loci. Of these, missense variants of SESN2 and PNPLA3 were predicted to be damaging to the function of these proteins; another five loci— TMEM18 , TM4SF4 , MXD3-LMAN2 , PSORS1C1-PSORS1C2 , and HNF4A —are related to cell metabolism, proliferation, or oxidative stress; and the remaining locus, LINC01578 , is unknown. We also identified 132 correlated genes whose expression levels are associated with SUA-increasing alleles. These genes are enriched for the UniProt transport term, suggesting the importance of transport-related genes in SUA regulation. Furthermore, trans-ethnic meta-analysis across our own meta-analysis and the Global Urate Genetics Consortium has revealed 15 more novel loci associated with SUA. Our findings provide insight into the pathogenesis, treatment, and prevention of hyperuricemia/gout. Masahiro Nakatochi et al. report a genome-wide meta-analysis of serum uric acid levels in the Japanese population. They identify 36 loci, including eight previously unreported loci, suggesting key cellular processes that contribute to elevated serum uric acid levels, which can lead to gout.
Gout is a common arthritis caused by elevated serum uric acid (SUA) levels. Here we investigated loci influencing SUA in a genome-wide meta-analysis with 121,745 Japanese subjects. We identified 8948 variants at 36 genomic loci ( <5 × 10 ) including eight novel loci. Of these, missense variants of and were predicted to be damaging to the function of these proteins; another five loci- , , , , and -are related to cell metabolism, proliferation, or oxidative stress; and the remaining locus, , is unknown. We also identified 132 correlated genes whose expression levels are associated with SUA-increasing alleles. These genes are enriched for the UniProt transport term, suggesting the importance of transport-related genes in SUA regulation. Furthermore, trans-ethnic meta-analysis across our own meta-analysis and the Global Urate Genetics Consortium has revealed 15 more novel loci associated with SUA. Our findings provide insight into the pathogenesis, treatment, and prevention of hyperuricemia/gout.
Gout is a common arthritis caused by elevated serum uric acid (SUA) levels. Here we investigated loci influencing SUA in a genome-wide meta-analysis with 121,745 Japanese subjects. We identified 8948 variants at 36 genomic loci (P<5 × 10-8) including eight novel loci. Of these, missense variants of SESN2 and PNPLA3 were predicted to be damaging to the function of these proteins; another five loci-TMEM18, TM4SF4, MXD3-LMAN2, PSORS1C1-PSORS1C2, and HNF4A-are related to cell metabolism, proliferation, or oxidative stress; and the remaining locus, LINC01578, is unknown. We also identified 132 correlated genes whose expression levels are associated with SUA-increasing alleles. These genes are enriched for the UniProt transport term, suggesting the importance of transport-related genes in SUA regulation. Furthermore, trans-ethnic meta-analysis across our own meta-analysis and the Global Urate Genetics Consortium has revealed 15 more novel loci associated with SUA. Our findings provide insight into the pathogenesis, treatment, and prevention of hyperuricemia/gout.Gout is a common arthritis caused by elevated serum uric acid (SUA) levels. Here we investigated loci influencing SUA in a genome-wide meta-analysis with 121,745 Japanese subjects. We identified 8948 variants at 36 genomic loci (P<5 × 10-8) including eight novel loci. Of these, missense variants of SESN2 and PNPLA3 were predicted to be damaging to the function of these proteins; another five loci-TMEM18, TM4SF4, MXD3-LMAN2, PSORS1C1-PSORS1C2, and HNF4A-are related to cell metabolism, proliferation, or oxidative stress; and the remaining locus, LINC01578, is unknown. We also identified 132 correlated genes whose expression levels are associated with SUA-increasing alleles. These genes are enriched for the UniProt transport term, suggesting the importance of transport-related genes in SUA regulation. Furthermore, trans-ethnic meta-analysis across our own meta-analysis and the Global Urate Genetics Consortium has revealed 15 more novel loci associated with SUA. Our findings provide insight into the pathogenesis, treatment, and prevention of hyperuricemia/gout.
Gout is a common arthritis caused by elevated serum uric acid (SUA) levels. Here we investigated loci influencing SUA in a genome-wide meta-analysis with 121,745 Japanese subjects. We identified 8948 variants at 36 genomic loci (P<5 × 10–8) including eight novel loci. Of these, missense variants of SESN2 and PNPLA3 were predicted to be damaging to the function of these proteins; another five loci—TMEM18, TM4SF4, MXD3-LMAN2, PSORS1C1-PSORS1C2, and HNF4A—are related to cell metabolism, proliferation, or oxidative stress; and the remaining locus, LINC01578, is unknown. We also identified 132 correlated genes whose expression levels are associated with SUA-increasing alleles. These genes are enriched for the UniProt transport term, suggesting the importance of transport-related genes in SUA regulation. Furthermore, trans-ethnic meta-analysis across our own meta-analysis and the Global Urate Genetics Consortium has revealed 15 more novel loci associated with SUA. Our findings provide insight into the pathogenesis, treatment, and prevention of hyperuricemia/gout.Masahiro Nakatochi et al. report a genome-wide meta-analysis of serum uric acid levels in the Japanese population. They identify 36 loci, including eight previously unreported loci, suggesting key cellular processes that contribute to elevated serum uric acid levels, which can lead to gout.
Gout is a common arthritis caused by elevated serum uric acid (SUA) levels. Here we investigated loci influencing SUA in a genome-wide meta-analysis with 121,745 Japanese subjects. We identified 8948 variants at 36 genomic loci ( P <5 × 10 –8 ) including eight novel loci. Of these, missense variants of SESN2 and PNPLA3 were predicted to be damaging to the function of these proteins; another five loci— TMEM18 , TM4SF4 , MXD3-LMAN2 , PSORS1C1-PSORS1C2 , and HNF4A —are related to cell metabolism, proliferation, or oxidative stress; and the remaining locus, LINC01578 , is unknown. We also identified 132 correlated genes whose expression levels are associated with SUA-increasing alleles. These genes are enriched for the UniProt transport term, suggesting the importance of transport-related genes in SUA regulation. Furthermore, trans-ethnic meta-analysis across our own meta-analysis and the Global Urate Genetics Consortium has revealed 15 more novel loci associated with SUA. Our findings provide insight into the pathogenesis, treatment, and prevention of hyperuricemia/gout.
Gout is a common arthritis caused by elevated serum uric acid (SUA) levels. Here we investigated loci influencing SUA in a genome-wide meta-analysis with 121,745 Japanese subjects. We identified 8948 variants at 36 genomic loci (P<5 × 10-8) including eight novel loci. Of these, missense variants of SESN2 and PNPLA3 were predicted to be damaging to the function of these proteins; another five loci-TMEM18, TM4SF4, MXD3-LMAN2, PSORS1C1-PSORS1C2, and HNF4A-are related to cell metabolism, proliferation, or oxidative stress; and the remaining locus, LINC01578, is unknown. We also identified 132 correlated genes whose expression levels are associated with SUA-increasing alleles. These genes are enriched for the UniProt transport term, suggesting the importance of transport-related genes in SUA regulation. Furthermore, trans-ethnic meta-analysis across our own meta-analysis and the Global Urate Genetics Consortium has revealed 15 more novel loci associated with SUA. Our findings provide insight into the pathogenesis, treatment, and prevention of hyperuricemia/gout.
ArticleNumber 115
Author Kawai, Sayo
Hirata, Makoto
Kawaguchi, Makoto
Yamamoto, Ken
Akiyama, Masato
Ibusuki, Rie
Kamatani, Yoichiro
Ikezaki, Hiroaki
Endoh, Kaori
Kita, Yoshikuni
Hishida, Asahi
Kubo, Michiaki
Oze, Isao
Matsubara, Tatsuaki
Naito, Mariko
Kato, Norihiro
Suzuki, Sadao
Matsuda, Koichi
Kuriki, Kiyonori
Takashima, Naoyuki
Uemura, Hirokazu
Okada, Yukinori
Wakai, Kenji
Nakamura, Takahiro
Shimanoe, Chisato
Takezaki, Toshiro
Yokota, Mitsuhiro
Nakajima, Mayuko
Ozaki, Etsuko
Okada, Rieko
Ichihara, Sahoko
Nakayama, Akiyoshi
Nakamura, Yohko
Shinomiya, Nariyoshi
Matsui, Daisuke
Tamura, Takashi
Arisawa, Kokichi
Matsuo, Hirotaka
Furusyo, Norihiro
Shimizu, Seiko
Kawamura, Yusuke
Nakashima, Hiroshi
Nakatochi, Masahiro
Kanai, Masahiro
Mikami, Haruo
Nishida, Yuichiro
Nishiyama, Takeshi
Takao, Mikiya
Matsuo, Keitaro
Murakami, Yoshinori
Author_xml – sequence: 1
  givenname: Masahiro
  orcidid: 0000-0002-1838-4837
  surname: Nakatochi
  fullname: Nakatochi, Masahiro
  organization: Data Science Division, Data Coordinating Center, Department of Advanced Medicine, Nagoya University Hospital
– sequence: 2
  givenname: Masahiro
  orcidid: 0000-0001-5165-4408
  surname: Kanai
  fullname: Kanai, Masahiro
  organization: Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Department of Statistical Genetics, Osaka University Graduate School of Medicine, Department of Biomedical Informatics, Harvard Medical School
– sequence: 3
  givenname: Akiyoshi
  surname: Nakayama
  fullname: Nakayama, Akiyoshi
  organization: Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Medical Squadron, Air Base Group, Western Aircraft Control and Warning Wing, Japan Air Self-Defense Force
– sequence: 4
  givenname: Asahi
  surname: Hishida
  fullname: Hishida, Asahi
  organization: Department of Preventive Medicine, Nagoya University Graduate School of Medicine
– sequence: 5
  givenname: Yusuke
  surname: Kawamura
  fullname: Kawamura, Yusuke
  organization: Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Department of General Medicine, National Defense Medical College
– sequence: 6
  givenname: Sahoko
  surname: Ichihara
  fullname: Ichihara, Sahoko
  organization: Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine
– sequence: 7
  givenname: Masato
  surname: Akiyama
  fullname: Akiyama, Masato
  organization: Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University
– sequence: 8
  givenname: Hiroaki
  surname: Ikezaki
  fullname: Ikezaki, Hiroaki
  organization: Department of General Internal Medicine, Kyushu University Hospital
– sequence: 9
  givenname: Norihiro
  surname: Furusyo
  fullname: Furusyo, Norihiro
  organization: Department of General Internal Medicine, Kyushu University Hospital
– sequence: 10
  givenname: Seiko
  surname: Shimizu
  fullname: Shimizu, Seiko
  organization: Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College
– sequence: 11
  givenname: Ken
  orcidid: 0000-0002-1531-9685
  surname: Yamamoto
  fullname: Yamamoto, Ken
  organization: Department of Medical Biochemistry, Kurume University School of Medicine
– sequence: 12
  givenname: Makoto
  orcidid: 0000-0002-9994-9958
  surname: Hirata
  fullname: Hirata, Makoto
  organization: Laboratory of Genome Technology, Institute of Medical Science, The University of Tokyo
– sequence: 13
  givenname: Rieko
  orcidid: 0000-0002-6206-2501
  surname: Okada
  fullname: Okada, Rieko
  organization: Department of Preventive Medicine, Nagoya University Graduate School of Medicine
– sequence: 14
  givenname: Sayo
  orcidid: 0000-0002-5156-4880
  surname: Kawai
  fullname: Kawai, Sayo
  organization: Department of Preventive Medicine, Nagoya University Graduate School of Medicine
– sequence: 15
  givenname: Makoto
  surname: Kawaguchi
  fullname: Kawaguchi, Makoto
  organization: Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Department of Urology, National Defense Medical College
– sequence: 16
  givenname: Yuichiro
  orcidid: 0000-0003-2320-7234
  surname: Nishida
  fullname: Nishida, Yuichiro
  organization: Department of Preventive Medicine, Faculty of Medicine, Saga University
– sequence: 17
  givenname: Chisato
  surname: Shimanoe
  fullname: Shimanoe, Chisato
  organization: Department of Preventive Medicine, Faculty of Medicine, Saga University
– sequence: 18
  givenname: Rie
  surname: Ibusuki
  fullname: Ibusuki, Rie
  organization: International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
– sequence: 19
  givenname: Toshiro
  surname: Takezaki
  fullname: Takezaki, Toshiro
  organization: International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
– sequence: 20
  givenname: Mayuko
  surname: Nakajima
  fullname: Nakajima, Mayuko
  organization: Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College
– sequence: 21
  givenname: Mikiya
  surname: Takao
  fullname: Takao, Mikiya
  organization: Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Department of Surgery, National Defense Medical College
– sequence: 22
  givenname: Etsuko
  surname: Ozaki
  fullname: Ozaki, Etsuko
  organization: Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
– sequence: 23
  givenname: Daisuke
  surname: Matsui
  fullname: Matsui, Daisuke
  organization: Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
– sequence: 24
  givenname: Takeshi
  surname: Nishiyama
  fullname: Nishiyama, Takeshi
  organization: Department of Public Health, Nagoya City University Graduate School of Medical Sciences
– sequence: 25
  givenname: Sadao
  surname: Suzuki
  fullname: Suzuki, Sadao
  organization: Department of Public Health, Nagoya City University Graduate School of Medical Sciences
– sequence: 26
  givenname: Naoyuki
  surname: Takashima
  fullname: Takashima, Naoyuki
  organization: Department of Health Science, Shiga University of Medical Science
– sequence: 27
  givenname: Yoshikuni
  orcidid: 0000-0002-2366-1106
  surname: Kita
  fullname: Kita, Yoshikuni
  organization: Department of Nursing, Tsuruga City College of Nursing
– sequence: 28
  givenname: Kaori
  surname: Endoh
  fullname: Endoh, Kaori
  organization: Laboratory of Public Health, Division of Nutritional Sciences, School of Food and Nutritional Sciences, University of Shizuoka
– sequence: 29
  givenname: Kiyonori
  surname: Kuriki
  fullname: Kuriki, Kiyonori
  organization: Laboratory of Public Health, Division of Nutritional Sciences, School of Food and Nutritional Sciences, University of Shizuoka
– sequence: 30
  givenname: Hirokazu
  orcidid: 0000-0002-0443-4266
  surname: Uemura
  fullname: Uemura, Hirokazu
  organization: Department of Preventive Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School
– sequence: 31
  givenname: Kokichi
  surname: Arisawa
  fullname: Arisawa, Kokichi
  organization: Department of Preventive Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School
– sequence: 32
  givenname: Isao
  orcidid: 0000-0002-0762-1147
  surname: Oze
  fullname: Oze, Isao
  organization: Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute
– sequence: 33
  givenname: Keitaro
  orcidid: 0000-0003-1761-6314
  surname: Matsuo
  fullname: Matsuo, Keitaro
  organization: Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Department of Epidemiology, Nagoya University Graduate School of Medicine
– sequence: 34
  givenname: Yohko
  surname: Nakamura
  fullname: Nakamura, Yohko
  organization: Cancer Prevention Center, Chiba Cancer Center Research Institute
– sequence: 35
  givenname: Haruo
  surname: Mikami
  fullname: Mikami, Haruo
  organization: Cancer Prevention Center, Chiba Cancer Center Research Institute
– sequence: 36
  givenname: Takashi
  surname: Tamura
  fullname: Tamura, Takashi
  organization: Department of Preventive Medicine, Nagoya University Graduate School of Medicine
– sequence: 37
  givenname: Hiroshi
  surname: Nakashima
  fullname: Nakashima, Hiroshi
  organization: Department of Preventive Medicine and Public Health, National Defense Medical College
– sequence: 38
  givenname: Takahiro
  surname: Nakamura
  fullname: Nakamura, Takahiro
  organization: Laboratory for Mathematics, National Defense Medical College
– sequence: 39
  givenname: Norihiro
  surname: Kato
  fullname: Kato, Norihiro
  organization: Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine
– sequence: 40
  givenname: Koichi
  orcidid: 0000-0001-7292-2686
  surname: Matsuda
  fullname: Matsuda, Koichi
  organization: Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo
– sequence: 41
  givenname: Yoshinori
  surname: Murakami
  fullname: Murakami, Yoshinori
  organization: Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo
– sequence: 42
  givenname: Tatsuaki
  surname: Matsubara
  fullname: Matsubara, Tatsuaki
  organization: Department of Internal Medicine, School of Dentistry, Aichi Gakuin University
– sequence: 43
  givenname: Mariko
  surname: Naito
  fullname: Naito, Mariko
  organization: Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Department of Oral Epidemiology, Hiroshima University Graduate School of Biomedical & Health Sciences
– sequence: 44
  givenname: Michiaki
  surname: Kubo
  fullname: Kubo, Michiaki
  organization: RIKEN Center for Integrative Medical Sciences
– sequence: 45
  givenname: Yoichiro
  orcidid: 0000-0001-8748-5597
  surname: Kamatani
  fullname: Kamatani, Yoichiro
  organization: Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Center for Genomic Medicine, Kyoto University Graduate School of Medicine
– sequence: 46
  givenname: Nariyoshi
  surname: Shinomiya
  fullname: Shinomiya, Nariyoshi
  organization: Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College
– sequence: 47
  givenname: Mitsuhiro
  surname: Yokota
  fullname: Yokota, Mitsuhiro
  organization: Department of Genome Science, School of Dentistry, Aichi Gakuin University
– sequence: 48
  givenname: Kenji
  surname: Wakai
  fullname: Wakai, Kenji
  organization: Department of Preventive Medicine, Nagoya University Graduate School of Medicine
– sequence: 49
  givenname: Yukinori
  orcidid: 0000-0002-0311-8472
  surname: Okada
  fullname: Okada, Yukinori
  organization: Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Department of Statistical Genetics, Osaka University Graduate School of Medicine, Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University
– sequence: 50
  givenname: Hirotaka
  surname: Matsuo
  fullname: Matsuo, Hirotaka
  email: hmatsuo@ndmc.ac.jp
  organization: Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30993211$$D View this record in MEDLINE/PubMed
BookMark eNqFkk1v1DAQhi1URMvSH8AFWeLCJeCPOIkvSKiCAqrEBc6WE09aV4692Mmu-u870ZZSKgEHeyzPM69nPPOcHMUUgZCXnL3lTHbvSi0YkxXjumJS4vaEnAipdSWbWhw9OB-T01KuGUNS60bWz8ixZFpLwfkJ2Z9DTBNUe--ATjDbykYbboovFG_i7EcPhU5LmP02AI1pB4GGNHhqS0FjZ3B07-crWiAvE12yH6gdvKMBEEWVSL_arY1QAM_O77xbbCgvyNMRDZze2Q358enj97PP1cW38y9nHy6qoeFyrup2VExxAA1Nr5wanR5V2wKuruYdR3_Xsrqre676UdpRqp453UsugDvRyw15f9DdLv0EbsCSsg1mm_1k841J1ps_PdFfmcu0M02tpBYtCry5E8jp5wJlNpMvA4SAJaWlGCFlIxSTmv8fFZxp1bGuQfT1I_Q6LRl_fhXsGiREswq-epj8fda_2ocAPwBDTqVkGO8Rzsw6JeYwJQZ7b9YpwW1D2kcxg5_t7NNavw__jBSHyIKvxEvIv5P-e9AtMAnRfw
CitedBy_id crossref_primary_10_1093_rheumatology_keac597
crossref_primary_10_1007_s13577_021_00665_2
crossref_primary_10_1016_j_berh_2021_101721
crossref_primary_10_1186_s13075_021_02580_1
crossref_primary_10_1038_s10038_021_00991_1
crossref_primary_10_3390_nu14194030
crossref_primary_10_1002_art_42838
crossref_primary_10_1152_physiolgenomics_00120_2023
crossref_primary_10_3389_fphar_2022_964593
crossref_primary_10_1002_advs_202404047
crossref_primary_10_1186_s13075_020_2136_z
crossref_primary_10_1186_s13075_022_02933_4
crossref_primary_10_1016_j_jbspin_2025_105876
crossref_primary_10_3390_ijms22020588
crossref_primary_10_1007_s11033_023_08359_8
crossref_primary_10_1136_bmjopen_2021_053763
crossref_primary_10_1097_MD_0000000000038722
crossref_primary_10_1093_hmg_ddac094
crossref_primary_10_1093_rheumatology_keae492
crossref_primary_10_1016_j_berh_2021_101717
crossref_primary_10_1186_s13075_021_02444_8
crossref_primary_10_1016_j_jep_2024_118817
crossref_primary_10_3390_nu17010198
crossref_primary_10_1038_s42003_024_07338_4
crossref_primary_10_7554_eLife_58615
crossref_primary_10_1038_s10038_020_0821_z
crossref_primary_10_3389_fendo_2021_742411
crossref_primary_10_1007_s13577_021_00485_4
crossref_primary_10_4162_nrp_2024_18_5_721
crossref_primary_10_1534_g3_120_401242
crossref_primary_10_1007_s13577_019_00318_5
crossref_primary_10_1002_acr2_11425
crossref_primary_10_1007_s13577_024_01128_0
crossref_primary_10_1038_s41584_024_01137_1
crossref_primary_10_1080_07853890_2024_2434186
crossref_primary_10_1136_annrheumdis_2019_216644
crossref_primary_10_2188_jea_JE20200147
crossref_primary_10_3390_ijms252312690
crossref_primary_10_1186_s11658_021_00302_8
crossref_primary_10_1007_s13577_021_00609_w
crossref_primary_10_3389_fcell_2020_00703
crossref_primary_10_3389_fcell_2022_937855
crossref_primary_10_1093_rheumatology_keab327
crossref_primary_10_1093_rheumatology_keab404
crossref_primary_10_1111_1440_1681_13539
crossref_primary_10_1534_genetics_119_303006
crossref_primary_10_3390_ijms221910641
crossref_primary_10_1186_s13075_022_02755_4
crossref_primary_10_1038_s41584_019_0334_3
crossref_primary_10_1136_annrheumdis_2019_215521
crossref_primary_10_1016_j_semnephrol_2020_12_002
crossref_primary_10_3390_biomedicines11123169
crossref_primary_10_3390_sym14020186
crossref_primary_10_1093_rheumatology_keaa461
crossref_primary_10_1016_j_cpcardiol_2021_100798
crossref_primary_10_1093_hmg_ddaa013
crossref_primary_10_3390_ijms21124269
crossref_primary_10_1016_j_semarthrit_2020_06_015
crossref_primary_10_1186_s12891_024_08180_9
crossref_primary_10_1038_s41598_020_66064_z
crossref_primary_10_1016_j_bbrc_2024_149809
crossref_primary_10_3390_cells10092243
crossref_primary_10_1007_s13577_024_01138_y
crossref_primary_10_1038_s41581_020_0298_1
crossref_primary_10_1038_s41572_019_0115_y
crossref_primary_10_1007_s00394_022_03076_7
crossref_primary_10_1016_j_jbc_2021_100623
crossref_primary_10_1073_pnas_2006958117
crossref_primary_10_1016_j_lanwpc_2023_100848
Cites_doi 10.1056/NEJMoa035700
10.1038/ncomms1756
10.1016/j.dld.2012.12.006
10.1186/1471-2350-11-58
10.1038/ng.531
10.1186/ar1906
10.1371/journal.pgen.1000504
10.1002/acn3.167
10.1038/srep05227
10.1038/nature742
10.1002/art.23752
10.1053/j.gastro.2016.04.007
10.1038/35093050
10.1016/j.ajhg.2008.11.001
10.1093/bioinformatics/btq340
10.1371/journal.pone.0189223
10.1111/j.0006-341X.1999.00997.x
10.1038/ng.106
10.1038/ncomms8041
10.4161/cc.7.4.5413
10.1093/hmg/ddt064
10.1038/ng.274
10.1016/S0140-6736(04)16000-5
10.1016/j.diabres.2011.02.029
10.1093/nar/gkq603
10.1038/ng.107
10.1016/j.cmet.2013.07.008
10.1002/gepi.20630
10.1016/S0140-6736(08)61343-4
10.1126/scitranslmed.3000237
10.1038/s41467-018-03274-0
10.1371/journal.pgen.0030194
10.1136/bmj.39449.819271.BE
10.1016/j.dmpk.2016.07.004
10.1155/2017/3296294
10.1073/pnas.78.11.6858
10.1038/srep31003
10.1136/annrheumdis-2016-209632
10.1038/ng.972
10.1038/ng.2500
10.1016/j.je.2016.12.003
10.1073/pnas.1707310114
10.1186/ar4365
10.1073/pnas.0901249106
10.2188/jea.JE20100139
10.1056/NEJMra0800885
10.1111/cei.12831
10.1016/j.je.2016.12.005
10.1016/j.cmet.2013.08.018
10.1136/annrheumdis-2014-206191
10.1038/nrrheum.2012.144
10.1097/BOR.0b013e3283257b96
10.1093/hmg/ddr307
10.1038/srep03755
10.1161/CIRCGENETICS.109.934455
10.1038/s41588-018-0047-6
10.1038/ng.3211
10.1038/nprot.2008.211
10.1371/journal.pone.0169956
10.1038/nature11966
10.1248/bpb.33.498
10.1038/ng.2352
10.1186/gm118
10.1016/S0140-6736(16)00346-9
10.1242/dev.058693
10.1038/cdd.2013.187
10.1038/nature24277
10.1007/s00125-009-1517-2
10.1371/journal.pone.0185490
10.1038/ng.257
10.1111/bjh.13066
10.1016/j.ajhg.2016.05.001
10.1101/362277
ContentType Journal Article
Copyright The Author(s) 2019
The Author(s) 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2019
– notice: The Author(s) 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7XB
88I
8FE
8FH
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
GNUQQ
HCIFZ
LK8
M2P
M7P
PHGZM
PHGZT
PIMPY
PKEHL
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
DOI 10.1038/s42003-019-0339-0
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
ProQuest Central (purchase pre-March 2016)
Science Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central
ProQuest Central Student
SciTech Premium Collection
Biological Sciences
Science Database
Biological Science Database
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Central
ProQuest One Applied & Life Sciences
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest Central (New)
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest Science Journals
ProQuest One Academic Eastern Edition
Biological Science Database
ProQuest SciTech Collection
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
MEDLINE
MEDLINE - Academic

Publicly Available Content Database
CrossRef
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2399-3642
EndPage 115
ExternalDocumentID PMC6453927
30993211
10_1038_s42003_019_0339_0
Genre Research Support, Non-U.S. Gov't
Meta-Analysis
Journal Article
GeographicLocations Japan
GeographicLocations_xml – name: Japan
GrantInformation_xml – fundername: MEXT | Japan Society for the Promotion of Science (JSPS)
  grantid: no. 16H06277
  funderid: https://doi.org/10.13039/501100001691
– fundername: MEXT | JST | Exploratory Research for Advanced Technology (ERATO)
  grantid: no. 221S0001
  funderid: https://doi.org/10.13039/501100009024
– fundername: Ministry of Education, Culture, Sports, Science and Technology (MEXT)
  grantid: no. 25293145; no.15K15227; no. 17015018
  funderid: https://doi.org/10.13039/501100001700
– fundername: ;
  grantid: no. 221S0001
– fundername: ;
  grantid: no. 25293145; no.15K15227; no. 17015018
– fundername: ;
  grantid: no. 16H06277
GroupedDBID 0R~
53G
88I
AAJSJ
ABDBF
ABUWG
ACGFS
ACSMW
ACUHS
ADBBV
AFKRA
AJTQC
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BBNVY
BCNDV
BENPR
BHPHI
C6C
CCPQU
DWQXO
EBLON
EBS
EJD
GNUQQ
GROUPED_DOAJ
HCIFZ
HYE
M2P
M7P
M~E
NAO
O9-
OK1
PGMZT
PIMPY
RNT
RPM
SNYQT
AASML
AAYXX
CITATION
PHGZM
PHGZT
CGR
CUY
CVF
ECM
EIF
H13
NPM
3V.
7XB
8FE
8FH
8FK
AARCD
LK8
PKEHL
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
ID FETCH-LOGICAL-c613t-47f5051ee9e6b5d5fd9f577e5778418147f870484b15bf3af35b0d9b312e1d2b3
IEDL.DBID C6C
ISSN 2399-3642
IngestDate Thu Aug 21 18:04:30 EDT 2025
Fri Jul 11 10:00:17 EDT 2025
Fri Jul 11 06:04:06 EDT 2025
Wed Aug 13 07:36:11 EDT 2025
Thu Apr 03 06:52:23 EDT 2025
Tue Jul 01 03:01:18 EDT 2025
Thu Apr 24 23:01:40 EDT 2025
Fri Feb 21 02:40:12 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c613t-47f5051ee9e6b5d5fd9f577e5778418147f870484b15bf3af35b0d9b312e1d2b3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0002-9994-9958
0000-0001-5165-4408
0000-0002-0443-4266
0000-0002-1838-4837
0000-0002-0762-1147
0000-0002-1531-9685
0000-0002-2366-1106
0000-0001-7292-2686
0000-0003-2320-7234
0000-0002-5156-4880
0000-0002-0311-8472
0000-0001-8748-5597
0000-0002-6206-2501
0000-0003-1761-6314
OpenAccessLink https://www.nature.com/articles/s42003-019-0339-0
PMID 30993211
PQID 2386863261
PQPubID 23479
PageCount 1
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_6453927
proquest_miscellaneous_2336250391
proquest_miscellaneous_2210958086
proquest_journals_2386863261
pubmed_primary_30993211
crossref_primary_10_1038_s42003_019_0339_0
crossref_citationtrail_10_1038_s42003_019_0339_0
springer_journals_10_1038_s42003_019_0339_0
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2019-04-08
PublicationDateYYYYMMDD 2019-04-08
PublicationDate_xml – month: 04
  year: 2019
  text: 2019-04-08
  day: 08
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Communications biology
PublicationTitleAbbrev Commun Biol
PublicationTitleAlternate Commun Biol
PublicationYear 2019
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References Kolz (CR20) 2009; 5
Matsuo (CR2) 2015; 2
Matsuo (CR39) 2014; 4
Vitart (CR17) 2008; 40
Yoon (CR50) 2001; 413
Brown, Ye, Price, Zaitlen (CR72) 2016; 99
McArdle (CR18) 2008; 58
Chandra (CR49) 2013; 495
Potting (CR67) 2013; 18
Yang (CR21) 2010; 3
Enomoto (CR59) 2002; 417
GTEx Consortium (CR35) 2017; 550
Romeo (CR56) 2008; 40
Li (CR58) 2015; 6
Woodward (CR8) 2009; 106
Ichida (CR62) 2009; 1
Satake (CR46) 2014; 167
Ciccacci (CR54) 2016; 186
Allaeys, Marceau, Poubelle (CR66) 2013; 15
Higashino (CR61) 2016; 31
Morris (CR73) 2011; 35
Larder (CR43) 2017; 114
Huang da, Sherman, Lempicki (CR36) 2009; 4
Nagai (CR33) 2017; 27
Okada (CR38) 2018; 9
Köttgen (CR24) 2013; 45
Choi, Atkinson, Karlson, Willett, Curhan (CR4) 2004; 363
Nakayama (CR12) 2017; 76
Kamatani (CR25) 2010; 42
Valenti, Dongiovanni, Ginanni Corradini, Burza, Romeo (CR57) 2013; 45
Ames, Cathcart, Schwiers, Hochstein (CR1) 1981; 78
Feig, Kang, Johnson (CR13) 2008; 359
Choi, Curhan (CR6) 2008; 336
Conigliaro (CR53) 2017; 12
Choi, Atkinson, Karlson, Willett, Curhan (CR5) 2004; 350
Reginato, Mount, Yang, Choi (CR27) 2012; 8
Dehghan (CR19) 2008; 372
Sulem (CR23) 2011; 43
Ao, Zou, Wu (CR65) 2014; 21
Pasha, Eid, Eid, Gorin, Munusamy (CR52) 2017; 2017
Barisone, Yun, Diaz (CR47) 2008; 7
Li (CR15) 2007; 3
Dalbeth, Merriman, Stamp (CR3) 2016; 388
Ichida (CR9) 2012; 3
Lee, Budanov, Karin (CR51) 2013; 18
Matsuo (CR60) 2008; 83
Wang (CR74) 2013; 22
Asano (CR31) 2010; 53
Hamajima, Group (CR29) 2007; 8
Kawaguchi (CR55) 2018; 13
Döring (CR16) 2008; 40
Devlin, Roeder (CR68) 1999; 55
Wakai (CR30) 2011; 21
Hirata (CR34) 2017; 27
Anderson (CR44) 2011; 138
Nakatochi (CR32) 2011; 92
Nakayama (CR10) 2014; 4
Baciu (CR48) 2017; 12
Wang, Li, Hakonarson (CR71) 2010; 38
Matsuo (CR11) 2016; 75
Edwards (CR14) 2009; 21
Willer, Li, Abecasis (CR70) 2010; 26
Thorleifsson (CR41) 2009; 41
Sato (CR64) 2010; 33
Kanai (CR28) 2018; 50
Almen (CR42) 2010; 11
Tin (CR22) 2011; 20
Matsuo (CR40) 2016; 6
Nuki, Simkin (CR37) 2006; 8
Joshi (CR45) 2016; 151
Okada (CR26) 2012; 44
CR63
Bulik-Sullivan (CR69) 2015; 47
Matsuo (CR7) 2009; 1
HK Choi (339_CR5) 2004; 350
H Matsuo (339_CR60) 2008; 83
M Hirata (339_CR34) 2017; 27
P Conigliaro (339_CR53) 2017; 12
Y Okada (339_CR26) 2012; 44
V Vitart (339_CR17) 2008; 40
AM Reginato (339_CR27) 2012; 8
H Matsuo (339_CR39) 2014; 4
N Satake (339_CR46) 2014; 167
A Tin (339_CR22) 2011; 20
AD Joshi (339_CR45) 2016; 151
H Matsuo (339_CR40) 2016; 6
KR Anderson (339_CR44) 2011; 138
C Li (339_CR58) 2015; 6
M Sato (339_CR64) 2010; 33
V Chandra (339_CR49) 2013; 495
DI Feig (339_CR13) 2008; 359
B Devlin (339_CR68) 1999; 55
H Asano (339_CR31) 2010; 53
OM Woodward (339_CR8) 2009; 106
S Li (339_CR15) 2007; 3
R Larder (339_CR43) 2017; 114
S Romeo (339_CR56) 2008; 40
A Dehghan (339_CR19) 2008; 372
HK Choi (339_CR6) 2008; 336
GA Barisone (339_CR47) 2008; 7
HK Choi (339_CR4) 2004; 363
G Nuki (339_CR37) 2006; 8
BC Brown (339_CR72) 2016; 99
JC Yoon (339_CR50) 2001; 413
A Nakayama (339_CR12) 2017; 76
X Wang (339_CR74) 2013; 22
AP Morris (339_CR73) 2011; 35
Q Yang (339_CR21) 2010; 3
JH Lee (339_CR51) 2013; 18
T Kawaguchi (339_CR55) 2018; 13
W Huang da (339_CR36) 2009; 4
M Pasha (339_CR52) 2017; 2017
CJ Willer (339_CR70) 2010; 26
339_CR63
K Ichida (339_CR9) 2012; 3
K Wang (339_CR71) 2010; 38
Y Okada (339_CR38) 2018; 9
C Potting (339_CR67) 2013; 18
A Döring (339_CR16) 2008; 40
NL Edwards (339_CR14) 2009; 21
H Matsuo (339_CR11) 2016; 75
M Kanai (339_CR28) 2018; 50
A Nakayama (339_CR10) 2014; 4
X Ao (339_CR65) 2014; 21
L Valenti (339_CR57) 2013; 45
K Wakai (339_CR30) 2011; 21
C Ciccacci (339_CR54) 2016; 186
P Sulem (339_CR23) 2011; 43
I Allaeys (339_CR66) 2013; 15
N Dalbeth (339_CR3) 2016; 388
C Baciu (339_CR48) 2017; 12
T Higashino (339_CR61) 2016; 31
BN Ames (339_CR1) 1981; 78
PF McArdle (339_CR18) 2008; 58
K Ichida (339_CR62) 2009; 1
BK Bulik-Sullivan (339_CR69) 2015; 47
N Hamajima (339_CR29) 2007; 8
M Kolz (339_CR20) 2009; 5
M Nakatochi (339_CR32) 2011; 92
H Matsuo (339_CR7) 2009; 1
H Matsuo (339_CR2) 2015; 2
GTEx Consortium (339_CR35) 2017; 550
A Köttgen (339_CR24) 2013; 45
A Enomoto (339_CR59) 2002; 417
Y Kamatani (339_CR25) 2010; 42
G Thorleifsson (339_CR41) 2009; 41
MS Almen (339_CR42) 2010; 11
A Nagai (339_CR33) 2017; 27
References_xml – volume: 350
  start-page: 1093
  year: 2004
  end-page: 1103
  ident: CR5
  article-title: Purine-rich foods, dairy and protein intake, and the risk of gout in men
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa035700
– volume: 3
  year: 2012
  ident: CR9
  article-title: Decreased extra-renal urate excretion is a common cause of hyperuricemia
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms1756
– volume: 45
  start-page: 619
  year: 2013
  end-page: 624
  ident: CR57
  article-title: PNPLA3 I148M variant and hepatocellular carcinoma: a common genetic variant for a rare disease
  publication-title: Dig. Liver Dis.
  doi: 10.1016/j.dld.2012.12.006
– volume: 11
  year: 2010
  ident: CR42
  article-title: The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children
  publication-title: BMC Med. Genet.
  doi: 10.1186/1471-2350-11-58
– volume: 42
  start-page: 210
  year: 2010
  end-page: 215
  ident: CR25
  article-title: Genome-wide association study of hematological and biochemical traits in a Japanese population
  publication-title: Nat. Genet.
  doi: 10.1038/ng.531
– volume: 8
  start-page: S1
  issue: Suppl 1
  year: 2006
  ident: CR37
  article-title: A concise history of gout and hyperuricemia and their treatment
  publication-title: Arthritis Res. Ther.
  doi: 10.1186/ar1906
– volume: 5
  start-page: e1000504
  year: 2009
  ident: CR20
  article-title: Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1000504
– volume: 2
  start-page: 302
  year: 2015
  end-page: 306
  ident: CR2
  article-title: ABCG2 variant has opposing effects on onset ages of Parkinson’s disease and gout
  publication-title: Ann. Clin. Transl. Neurol.
  doi: 10.1002/acn3.167
– volume: 4
  year: 2014
  ident: CR10
  article-title: Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors
  publication-title: Sci. Rep.
  doi: 10.1038/srep05227
– volume: 8
  start-page: 317
  year: 2007
  end-page: 323
  ident: CR29
  article-title: The Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study) to detect gene-environment interactions for cancer
  publication-title: Asian Pac. J. Cancer Prev.
– volume: 417
  start-page: 447
  year: 2002
  end-page: 452
  ident: CR59
  article-title: Molecular identification of a renal urate anion exchanger that regulates blood urate levels
  publication-title: Nature
  doi: 10.1038/nature742
– volume: 58
  start-page: 2874
  year: 2008
  end-page: 2881
  ident: CR18
  article-title: Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish
  publication-title: Arthritis Rheum.
  doi: 10.1002/art.23752
– volume: 151
  start-page: 351
  year: 2016
  end-page: 363 e28
  ident: CR45
  article-title: Four susceptibility loci for gallstone disease identified in a meta-analysis of genome-wide association studies
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2016.04.007
– volume: 413
  start-page: 131
  year: 2001
  end-page: 138
  ident: CR50
  article-title: Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
  publication-title: Nature
  doi: 10.1038/35093050
– volume: 83
  start-page: 744
  year: 2008
  end-page: 751
  ident: CR60
  article-title: Mutations in glucose transporter 9 gene cause renal hypouricemia
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2008.11.001
– volume: 26
  start-page: 2190
  year: 2010
  end-page: 2191
  ident: CR70
  article-title: METAL: fast and efficient meta-analysis of genomewide association scans
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btq340
– volume: 12
  start-page: e0189223
  year: 2017
  ident: CR48
  article-title: Systematic integrative analysis of gene expression identifies HNF4A as the central gene in pathogenesis of non-alcoholic steatohepatitis
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0189223
– volume: 55
  start-page: 997
  year: 1999
  end-page: 1004
  ident: CR68
  article-title: Genomic control for association studies
  publication-title: Biometrics
  doi: 10.1111/j.0006-341X.1999.00997.x
– volume: 40
  start-page: 437
  year: 2008
  end-page: 442
  ident: CR17
  article-title: SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout
  publication-title: Nat. Genet.
  doi: 10.1038/ng.106
– volume: 6
  year: 2015
  ident: CR58
  article-title: Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms8041
– volume: 7
  start-page: 423
  year: 2008
  end-page: 427
  ident: CR47
  article-title: From cerebellar proliferation to tumorigenesis: new insights into the role of Mad3
  publication-title: Cell Cycle
  doi: 10.4161/cc.7.4.5413
– volume: 22
  start-page: 2303
  year: 2013
  end-page: 2311
  ident: CR74
  article-title: Comparing methods for performing trans-ethnic meta-analysis of genome-wide association studies
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddt064
– volume: 41
  start-page: 18
  year: 2009
  end-page: 24
  ident: CR41
  article-title: Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
  publication-title: Nat. Genet.
  doi: 10.1038/ng.274
– volume: 363
  start-page: 1277
  year: 2004
  end-page: 1281
  ident: CR4
  article-title: Alcohol intake and risk of incident gout in men: a prospective study
  publication-title: Lancet
  doi: 10.1016/S0140-6736(04)16000-5
– volume: 92
  start-page: e61
  year: 2011
  end-page: e65
  ident: CR32
  article-title: The ratio of adiponectin to homeostasis model assessment of insulin resistance is a powerful index of each component of metabolic syndrome in an aged Japanese population: results from the KING Study
  publication-title: Diabetes Res. Clin. Pract.
  doi: 10.1016/j.diabres.2011.02.029
– volume: 38
  start-page: e164
  year: 2010
  ident: CR71
  article-title: ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkq603
– volume: 40
  start-page: 430
  year: 2008
  end-page: 436
  ident: CR16
  article-title: SLC2A9 influences uric acid concentrations with pronounced sex-specific effects
  publication-title: Nat. Genet.
  doi: 10.1038/ng.107
– volume: 18
  start-page: 287
  year: 2013
  end-page: 295
  ident: CR67
  article-title: TRIAP1/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2013.07.008
– volume: 35
  start-page: 809
  year: 2011
  end-page: 822
  ident: CR73
  article-title: Transethnic meta-analysis of genomewide association studies
  publication-title: Genet. Epidemiol.
  doi: 10.1002/gepi.20630
– volume: 372
  start-page: 1953
  year: 2008
  end-page: 1961
  ident: CR19
  article-title: Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study
  publication-title: Lancet
  doi: 10.1016/S0140-6736(08)61343-4
– volume: 1
  start-page: 5ra11
  year: 2009
  ident: CR7
  article-title: Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3000237
– volume: 9
  year: 2018
  ident: CR38
  article-title: Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-03274-0
– volume: 3
  start-page: e194
  year: 2007
  ident: CR15
  article-title: The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.0030194
– volume: 336
  start-page: 309
  year: 2008
  end-page: 312
  ident: CR6
  article-title: Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study
  publication-title: BMJ
  doi: 10.1136/bmj.39449.819271.BE
– volume: 31
  start-page: 464
  year: 2016
  end-page: 466
  ident: CR61
  article-title: Common variant of PDZ domain containing 1 (PDZK1) gene is associated with gout susceptibility: A replication study and meta-analysis in Japanese population
  publication-title: Drug Metab. Pharmacokinet.
  doi: 10.1016/j.dmpk.2016.07.004
– volume: 2017
  start-page: 3296294
  year: 2017
  ident: CR52
  article-title: Sestrin2 as a novel biomarker and therapeutic target for various diseases
  publication-title: Oxid. Med. Cell Longev.
  doi: 10.1155/2017/3296294
– volume: 78
  start-page: 6858
  year: 1981
  end-page: 6862
  ident: CR1
  article-title: Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.78.11.6858
– volume: 6
  year: 2016
  ident: CR40
  article-title: Hyperuricemia in acute gastroenteritis is caused by decreased urate excretion via ABCG2
  publication-title: Sci. Rep.
  doi: 10.1038/srep31003
– volume: 76
  start-page: 869
  year: 2017
  end-page: 877
  ident: CR12
  article-title: GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes
  publication-title: Ann. Rheum. Dis.
  doi: 10.1136/annrheumdis-2016-209632
– volume: 43
  start-page: 1127
  year: 2011
  end-page: 1130
  ident: CR23
  article-title: Identification of low-frequency variants associated with gout and serum uric acid levels
  publication-title: Nat. Genet.
  doi: 10.1038/ng.972
– volume: 45
  start-page: 145
  year: 2013
  end-page: 154
  ident: CR24
  article-title: Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2500
– volume: 27
  start-page: S9
  year: 2017
  end-page: S21
  ident: CR34
  article-title: Cross-sectional analysis of BioBank Japan clinical data: A large cohort of 200,000 patients with 47 common diseases
  publication-title: J. Epidemiol.
  doi: 10.1016/j.je.2016.12.003
– volume: 114
  start-page: 9421
  year: 2017
  end-page: 9426
  ident: CR43
  article-title: Obesity-associated gene TMEM18 has a role in the central control of appetite and body weight regulation
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1707310114
– volume: 15
  start-page: R176
  year: 2013
  ident: CR66
  article-title: NLRP3 promotes autophagy of urate crystals phagocytized by human osteoblasts
  publication-title: Arthritis Res. Ther.
  doi: 10.1186/ar4365
– volume: 106
  start-page: 10338
  year: 2009
  end-page: 10342
  ident: CR8
  article-title: Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0901249106
– volume: 21
  start-page: 223
  year: 2011
  end-page: 235
  ident: CR30
  article-title: Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study
  publication-title: J. Epidemiol.
  doi: 10.2188/jea.JE20100139
– volume: 359
  start-page: 1811
  year: 2008
  end-page: 1821
  ident: CR13
  article-title: Uric acid and cardiovascular risk
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMra0800885
– ident: CR63
– volume: 186
  start-page: 157
  year: 2016
  end-page: 163
  ident: CR54
  article-title: Polymorphisms in STAT-4, IL-10, PSORS1C1, PTPN2 and MIR146A genes are associated differently with prognostic factors in Italian patients affected by rheumatoid arthritis
  publication-title: Clin. Exp. Immunol.
  doi: 10.1111/cei.12831
– volume: 27
  start-page: S2
  year: 2017
  end-page: S8
  ident: CR33
  article-title: Overview of the BioBank Japan Project: study design and profile
  publication-title: J. Epidemiol.
  doi: 10.1016/j.je.2016.12.005
– volume: 18
  start-page: 792
  year: 2013
  end-page: 801
  ident: CR51
  article-title: Sestrins orchestrate cellular metabolism to attenuate aging
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2013.08.018
– volume: 75
  start-page: 652
  year: 2016
  end-page: 659
  ident: CR11
  article-title: Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes
  publication-title: Ann. Rheum. Dis.
  doi: 10.1136/annrheumdis-2014-206191
– volume: 8
  start-page: 610
  year: 2012
  end-page: 621
  ident: CR27
  article-title: The genetics of hyperuricaemia and gout
  publication-title: Nat. Rev. Rheumatol.
  doi: 10.1038/nrrheum.2012.144
– volume: 21
  start-page: 132
  year: 2009
  end-page: 137
  ident: CR14
  article-title: The role of hyperuricemia in vascular disorders
  publication-title: Curr. Opin. Rheumatol.
  doi: 10.1097/BOR.0b013e3283257b96
– volume: 20
  start-page: 4056
  year: 2011
  end-page: 4068
  ident: CR22
  article-title: Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddr307
– volume: 4
  year: 2014
  ident: CR39
  article-title: ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload
  publication-title: Sci. Rep.
  doi: 10.1038/srep03755
– volume: 3
  start-page: 523
  year: 2010
  end-page: 530
  ident: CR21
  article-title: Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors
  publication-title: Circ. Cardiovasc. Genet.
  doi: 10.1161/CIRCGENETICS.109.934455
– volume: 50
  start-page: 390
  year: 2018
  end-page: 400
  ident: CR28
  article-title: Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-018-0047-6
– volume: 47
  start-page: 291
  year: 2015
  end-page: 295
  ident: CR69
  article-title: LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3211
– volume: 4
  start-page: 44
  year: 2009
  end-page: 57
  ident: CR36
  article-title: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2008.211
– volume: 12
  start-page: e0169956
  year: 2017
  ident: CR53
  article-title: Polymorphisms in STAT4, PTPN2, PSORS1C1 and TRAF3IP2 genes are associated with the response to TNF inhibitors in patients with rheumatoid arthritis
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0169956
– volume: 495
  start-page: 394
  year: 2013
  end-page: 398
  ident: CR49
  article-title: Multidomain integration in the structure of the HNF-4alpha nuclear receptor complex
  publication-title: Nature
  doi: 10.1038/nature11966
– volume: 33
  start-page: 498
  year: 2010
  end-page: 503
  ident: CR64
  article-title: Renal secretion of uric acid by organic anion transporter 2 (OAT2/SLC22A7) in human
  publication-title: Biol. Pharm. Bull.
  doi: 10.1248/bpb.33.498
– volume: 44
  start-page: 904
  year: 2012
  end-page: 909
  ident: CR26
  article-title: Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2352
– volume: 1
  year: 2009
  ident: CR62
  article-title: What lies behind serum urate concentration? Insights from genetic and genomic studies
  publication-title: Genome Med.
  doi: 10.1186/gm118
– volume: 388
  start-page: 2039
  year: 2016
  end-page: 2052
  ident: CR3
  article-title: Gout
  publication-title: Lancet
  doi: 10.1016/S0140-6736(16)00346-9
– volume: 138
  start-page: 3213
  year: 2011
  end-page: 3224
  ident: CR44
  article-title: The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration
  publication-title: Development
  doi: 10.1242/dev.058693
– volume: 21
  start-page: 348
  year: 2014
  end-page: 358
  ident: CR65
  article-title: Regulation of autophagy by the Rab GTPase network
  publication-title: Cell Death Differ.
  doi: 10.1038/cdd.2013.187
– volume: 550
  start-page: 204
  year: 2017
  end-page: 213
  ident: CR35
  article-title: Genetic effects on gene expression across human tissues
  publication-title: Nature
  doi: 10.1038/nature24277
– volume: 53
  start-page: 234
  year: 2010
  end-page: 246
  ident: CR31
  article-title: Plasma resistin concentration determined by common variants in the resistin gene and associated with metabolic traits in an aged Japanese population
  publication-title: Diabetologia
  doi: 10.1007/s00125-009-1517-2
– volume: 13
  start-page: e0185490
  year: 2018
  ident: CR55
  article-title: Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0185490
– volume: 40
  start-page: 1461
  year: 2008
  end-page: 1465
  ident: CR56
  article-title: Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
  publication-title: Nat. Genet.
  doi: 10.1038/ng.257
– volume: 167
  start-page: 487
  year: 2014
  end-page: 499
  ident: CR46
  article-title: Targeted therapy with MXD3 siRNA, anti-CD22 antibody and nanoparticles for precursor B-cell acute lymphoblastic leukaemia
  publication-title: Br. J. Haematol.
  doi: 10.1111/bjh.13066
– volume: 99
  start-page: 76
  year: 2016
  end-page: 88
  ident: CR72
  article-title: Transethnic genetic-correlation estimates from summary statistics
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2016.05.001
– volume: 43
  start-page: 1127
  year: 2011
  ident: 339_CR23
  publication-title: Nat. Genet.
  doi: 10.1038/ng.972
– volume: 53
  start-page: 234
  year: 2010
  ident: 339_CR31
  publication-title: Diabetologia
  doi: 10.1007/s00125-009-1517-2
– volume: 11
  year: 2010
  ident: 339_CR42
  publication-title: BMC Med. Genet.
  doi: 10.1186/1471-2350-11-58
– volume: 6
  year: 2016
  ident: 339_CR40
  publication-title: Sci. Rep.
  doi: 10.1038/srep31003
– volume: 47
  start-page: 291
  year: 2015
  ident: 339_CR69
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3211
– volume: 75
  start-page: 652
  year: 2016
  ident: 339_CR11
  publication-title: Ann. Rheum. Dis.
  doi: 10.1136/annrheumdis-2014-206191
– volume: 114
  start-page: 9421
  year: 2017
  ident: 339_CR43
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1707310114
– volume: 372
  start-page: 1953
  year: 2008
  ident: 339_CR19
  publication-title: Lancet
  doi: 10.1016/S0140-6736(08)61343-4
– volume: 21
  start-page: 223
  year: 2011
  ident: 339_CR30
  publication-title: J. Epidemiol.
  doi: 10.2188/jea.JE20100139
– volume: 99
  start-page: 76
  year: 2016
  ident: 339_CR72
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2016.05.001
– ident: 339_CR63
  doi: 10.1101/362277
– volume: 44
  start-page: 904
  year: 2012
  ident: 339_CR26
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2352
– volume: 8
  start-page: 610
  year: 2012
  ident: 339_CR27
  publication-title: Nat. Rev. Rheumatol.
  doi: 10.1038/nrrheum.2012.144
– volume: 38
  start-page: e164
  year: 2010
  ident: 339_CR71
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkq603
– volume: 31
  start-page: 464
  year: 2016
  ident: 339_CR61
  publication-title: Drug Metab. Pharmacokinet.
  doi: 10.1016/j.dmpk.2016.07.004
– volume: 58
  start-page: 2874
  year: 2008
  ident: 339_CR18
  publication-title: Arthritis Rheum.
  doi: 10.1002/art.23752
– volume: 21
  start-page: 348
  year: 2014
  ident: 339_CR65
  publication-title: Cell Death Differ.
  doi: 10.1038/cdd.2013.187
– volume: 4
  year: 2014
  ident: 339_CR10
  publication-title: Sci. Rep.
  doi: 10.1038/srep05227
– volume: 3
  start-page: e194
  year: 2007
  ident: 339_CR15
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.0030194
– volume: 138
  start-page: 3213
  year: 2011
  ident: 339_CR44
  publication-title: Development
  doi: 10.1242/dev.058693
– volume: 33
  start-page: 498
  year: 2010
  ident: 339_CR64
  publication-title: Biol. Pharm. Bull.
  doi: 10.1248/bpb.33.498
– volume: 1
  start-page: 5ra11
  year: 2009
  ident: 339_CR7
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3000237
– volume: 3
  start-page: 523
  year: 2010
  ident: 339_CR21
  publication-title: Circ. Cardiovasc. Genet.
  doi: 10.1161/CIRCGENETICS.109.934455
– volume: 495
  start-page: 394
  year: 2013
  ident: 339_CR49
  publication-title: Nature
  doi: 10.1038/nature11966
– volume: 151
  start-page: 351
  year: 2016
  ident: 339_CR45
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2016.04.007
– volume: 363
  start-page: 1277
  year: 2004
  ident: 339_CR4
  publication-title: Lancet
  doi: 10.1016/S0140-6736(04)16000-5
– volume: 78
  start-page: 6858
  year: 1981
  ident: 339_CR1
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.78.11.6858
– volume: 186
  start-page: 157
  year: 2016
  ident: 339_CR54
  publication-title: Clin. Exp. Immunol.
  doi: 10.1111/cei.12831
– volume: 1
  year: 2009
  ident: 339_CR62
  publication-title: Genome Med.
  doi: 10.1186/gm118
– volume: 41
  start-page: 18
  year: 2009
  ident: 339_CR41
  publication-title: Nat. Genet.
  doi: 10.1038/ng.274
– volume: 7
  start-page: 423
  year: 2008
  ident: 339_CR47
  publication-title: Cell Cycle
  doi: 10.4161/cc.7.4.5413
– volume: 12
  start-page: e0169956
  year: 2017
  ident: 339_CR53
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0169956
– volume: 5
  start-page: e1000504
  year: 2009
  ident: 339_CR20
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1000504
– volume: 4
  start-page: 44
  year: 2009
  ident: 339_CR36
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2008.211
– volume: 35
  start-page: 809
  year: 2011
  ident: 339_CR73
  publication-title: Genet. Epidemiol.
  doi: 10.1002/gepi.20630
– volume: 15
  start-page: R176
  year: 2013
  ident: 339_CR66
  publication-title: Arthritis Res. Ther.
  doi: 10.1186/ar4365
– volume: 417
  start-page: 447
  year: 2002
  ident: 339_CR59
  publication-title: Nature
  doi: 10.1038/nature742
– volume: 167
  start-page: 487
  year: 2014
  ident: 339_CR46
  publication-title: Br. J. Haematol.
  doi: 10.1111/bjh.13066
– volume: 3
  year: 2012
  ident: 339_CR9
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms1756
– volume: 350
  start-page: 1093
  year: 2004
  ident: 339_CR5
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa035700
– volume: 6
  year: 2015
  ident: 339_CR58
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms8041
– volume: 55
  start-page: 997
  year: 1999
  ident: 339_CR68
  publication-title: Biometrics
  doi: 10.1111/j.0006-341X.1999.00997.x
– volume: 388
  start-page: 2039
  year: 2016
  ident: 339_CR3
  publication-title: Lancet
  doi: 10.1016/S0140-6736(16)00346-9
– volume: 2
  start-page: 302
  year: 2015
  ident: 339_CR2
  publication-title: Ann. Clin. Transl. Neurol.
  doi: 10.1002/acn3.167
– volume: 359
  start-page: 1811
  year: 2008
  ident: 339_CR13
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMra0800885
– volume: 20
  start-page: 4056
  year: 2011
  ident: 339_CR22
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddr307
– volume: 27
  start-page: S9
  year: 2017
  ident: 339_CR34
  publication-title: J. Epidemiol.
  doi: 10.1016/j.je.2016.12.003
– volume: 8
  start-page: 317
  year: 2007
  ident: 339_CR29
  publication-title: Asian Pac. J. Cancer Prev.
– volume: 45
  start-page: 619
  year: 2013
  ident: 339_CR57
  publication-title: Dig. Liver Dis.
  doi: 10.1016/j.dld.2012.12.006
– volume: 18
  start-page: 287
  year: 2013
  ident: 339_CR67
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2013.07.008
– volume: 106
  start-page: 10338
  year: 2009
  ident: 339_CR8
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0901249106
– volume: 8
  start-page: S1
  issue: Suppl 1
  year: 2006
  ident: 339_CR37
  publication-title: Arthritis Res. Ther.
  doi: 10.1186/ar1906
– volume: 22
  start-page: 2303
  year: 2013
  ident: 339_CR74
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddt064
– volume: 2017
  start-page: 3296294
  year: 2017
  ident: 339_CR52
  publication-title: Oxid. Med. Cell Longev.
  doi: 10.1155/2017/3296294
– volume: 76
  start-page: 869
  year: 2017
  ident: 339_CR12
  publication-title: Ann. Rheum. Dis.
  doi: 10.1136/annrheumdis-2016-209632
– volume: 4
  year: 2014
  ident: 339_CR39
  publication-title: Sci. Rep.
  doi: 10.1038/srep03755
– volume: 12
  start-page: e0189223
  year: 2017
  ident: 339_CR48
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0189223
– volume: 413
  start-page: 131
  year: 2001
  ident: 339_CR50
  publication-title: Nature
  doi: 10.1038/35093050
– volume: 550
  start-page: 204
  year: 2017
  ident: 339_CR35
  publication-title: Nature
  doi: 10.1038/nature24277
– volume: 13
  start-page: e0185490
  year: 2018
  ident: 339_CR55
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0185490
– volume: 21
  start-page: 132
  year: 2009
  ident: 339_CR14
  publication-title: Curr. Opin. Rheumatol.
  doi: 10.1097/BOR.0b013e3283257b96
– volume: 83
  start-page: 744
  year: 2008
  ident: 339_CR60
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2008.11.001
– volume: 40
  start-page: 430
  year: 2008
  ident: 339_CR16
  publication-title: Nat. Genet.
  doi: 10.1038/ng.107
– volume: 42
  start-page: 210
  year: 2010
  ident: 339_CR25
  publication-title: Nat. Genet.
  doi: 10.1038/ng.531
– volume: 336
  start-page: 309
  year: 2008
  ident: 339_CR6
  publication-title: BMJ
  doi: 10.1136/bmj.39449.819271.BE
– volume: 18
  start-page: 792
  year: 2013
  ident: 339_CR51
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2013.08.018
– volume: 40
  start-page: 1461
  year: 2008
  ident: 339_CR56
  publication-title: Nat. Genet.
  doi: 10.1038/ng.257
– volume: 50
  start-page: 390
  year: 2018
  ident: 339_CR28
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-018-0047-6
– volume: 27
  start-page: S2
  year: 2017
  ident: 339_CR33
  publication-title: J. Epidemiol.
  doi: 10.1016/j.je.2016.12.005
– volume: 45
  start-page: 145
  year: 2013
  ident: 339_CR24
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2500
– volume: 26
  start-page: 2190
  year: 2010
  ident: 339_CR70
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btq340
– volume: 40
  start-page: 437
  year: 2008
  ident: 339_CR17
  publication-title: Nat. Genet.
  doi: 10.1038/ng.106
– volume: 92
  start-page: e61
  year: 2011
  ident: 339_CR32
  publication-title: Diabetes Res. Clin. Pract.
  doi: 10.1016/j.diabres.2011.02.029
– volume: 9
  year: 2018
  ident: 339_CR38
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-03274-0
SSID ssj0001999634
Score 2.376127
SecondaryResourceType review_article
Snippet Gout is a common arthritis caused by elevated serum uric acid (SUA) levels. Here we investigated loci influencing SUA in a genome-wide meta-analysis with...
SourceID pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 115
SubjectTerms 45
45/43
631/208/205/2138
692/699/1670/3/2765/1528
Alleles
Arthritis
Biology
Biomedical and Life Sciences
Computational Biology
Gene loci
Gene regulation
Genetic Predisposition to Disease
Genome-Wide Association Study
Genomes
Genotype
Gout
Gout - blood
Gout - etiology
Gout - metabolism
Hepatocyte nuclear factor 4
Humans
Hyperuricemia
Japan
Life Sciences
Meta-analysis
Molecular Sequence Annotation
Oxidative metabolism
Oxidative stress
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Quantitative Trait, Heritable
Rheumatism
Uric acid
Uric Acid - blood
SummonAdditionalLinks – databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9QwDLdgExIviG86BgoST6BobZO06RMCtDFNYkKISXurmsQVle7aQe828d_jtGlPx8Q9tC9xoya283NixwZ4qwurK1s7rlMbc0lSwbV1hitbGVMVBEjWX07-ep6dXsizS3UZDtz6EFY5rYnDQu0668_IjwhaMp2RsZF8uPrFfdUo710NJTTuwj4twZo2X_ufjs-_fd-csnh7XsjJnSn0US-HcKzY390Rgl7bgHTLyrwdLPmPx3QAopOH8CBYkOzjyPJHcAfbx3BvrCn55wncfMG2WyK_aRyyJa4qXoW8I6xxY2gQ9myKI2Rtd40LRojWsCpwCh3zp7OMhHO9ZD7rEKts49jCxxdRLy07I4T1lStZM1_n6p_Cxcnxj8-nPFRX4JYgfMVlXpP1kyAWmBnlVO2KWuU50qMl4T61ky5LLU2iTC2qWigTu8KIJMXEpUY8g722a_EFMKOQOsBCOkSpM19GXWaySK2yshKxiSCepri0IfW4r4CxKAcXuNDlyJWSuFJ6rpRxBO_mT67GvBu7iA8nvpVBBftyIzARvJmbSXm8R4QmqVsTDW14C6VpW7eDRhDGK59IP4LnoyjMfyTIvha0hY4g3xKSmcAn795uaZufQxLvTCoyTfMI3k_itPn1_w70YPdAX8L9dBBsyWN9CHur32t8RTbTyrwOivEXQQcXFQ
  priority: 102
  providerName: ProQuest
Title Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals
URI https://link.springer.com/article/10.1038/s42003-019-0339-0
https://www.ncbi.nlm.nih.gov/pubmed/30993211
https://www.proquest.com/docview/2386863261
https://www.proquest.com/docview/2210958086
https://www.proquest.com/docview/2336250391
https://pubmed.ncbi.nlm.nih.gov/PMC6453927
Volume 2
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3di9QwEB_OOwRfxG97nksEn5Rg2yRt-rgudx4LHqIe3FtpkikWdrvi7t7hf-8k_TjWxQMf2j5kUtLMpPNLMvkNwFtdWF3Z2nGd2phLsgqurTNc2cqYqiCHZP3h5M8X2fmlnF-pqwNIhrMwIWg_UFqG3_QQHfZhLUMUVeyP3AhBt3tw5JnbvVHPstntsooH8EIO-5dC79fc9UB7sHI_OvKvLdLgec4ewcMeMrJp18jHcIDtE7jfJZH8_RRuPmG7WiK_aRyyJW4qXvVEI6xxXSwQrtkQOMja1TUuGLmwhlW9atAxvxzLyBq3S-ZphlhlG8cWPqCI3tKyOblUn6qSNeP5rfUzuDw7_T475306BW7JZ2-4zGuCOwligZlRTtWuqFWeI11akqOnchq8UkuTKFOLqhbKxK4wIkkxcakRz-GwXbX4EphRSC_AQjpEqTOfN11mskitsrISsYkgHrq4tD3XuE95sSjDnrfQZaeVkrRSeq2UcQTvxio_O6KNu4RPBr2V_ZhblwQ-Mp0RHE0ieDMW02jxWyDUSastydAMt1Ca5nF3yAhy6soz50fwojOFsUWCALWgOXME-Y6RjAKerXu3pG1-BNbuTCrConkE7wdzum36Pz_0-L-kX8GDNNi55LE-gcPNry2-Jsy0MRM4mk7n3-b0_Hh68eXrJIyaSViB-APdthcK
linkProvider Springer Nature
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VrRBcEG9SChgJLiCrSWwnzgEhHi3b1wqhVuotjR8RkXaTluyy6p_iNzLOY1dLxd56SC52rNjzjWfGM54BeCMTLTOdGypD7VOOqKBSG0WFzpTKEhRI2l1OPh5Fw1N-cCbONuBPfxfGhVX2e2KzUZtKuzPyHRQtkYxQ2Qg-XlxSVzXKeVf7EhotLA7t1RxNtvrD_lek79sw3Ns9-TKkXVUBqlF0TSmPc5T6gbWJjZQwIjdJLuLY4iM5yjtsRwxzyVUgVM6ynAnlm0SxILSBCRXDcW_BJmdoygxg8_Pu6PuP5amOsx8Y792nTO7UvAn_8t1dIcbwtSoAr2m114Mz__HQNoJv7z7c6zRW8qmF2APYsOVDuN3WsLx6BPNvtqwmls4LY8nETjOadXlOSGHaUCRbkz5ukZTVbzsmKEELknXIsIa402CCzDCbEJfliGS6MGTs4plwlJIcoER3lTJJsbg-Vj-G0xtZ9ycwKKvSPgOihMUBbMKNtVxGrmw7j3gSaqF5xnzlgd8vcaq7VOeu4sY4bVzuTKYtVVKkSuqokvoevFt8ctHm-VjXebunW9qxfJ0uAerB60UzMqvzwOAiVTPsgwZ2IiSakWv6MNQphEvc78HTFgqLP2KozzM02T2IV0Cy6OCSha-2lMXPJml4xAWqwrEH73s4LX_9vxPdWj_RV3BneHJ8lB7tjw6fw92wATmnvtyGwfTXzL5AfW2qXnZMQuD8pvnyLzN8UyA
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwEB6VIhAXVN6BFozECWSaxHbiHNG2SylQcaBSb1ZsT0Sk3WzF7lLx7xnnVS0rKnFILh5bjmcm89meB8AbXThduspznbqYS5IKrp23XLnS2rIgg-RCcPLXs-zkXJ5eqIsdUEMsTOu036a0bH_Tg3fY4VK2XlRxCLkRgl7vL311C24T3I7DnmuSTa6PVgKIF3K4wxR6u_emFdqCltsekn9dk7bWZ7oH93vYyD50E30AO9g8hDtdIcnfj-DqIzaLOfKr2iOb46rkZZ9shNW-8wfCJRucB1mz-IUzRmasZmXPHvQsHMkyksj1nIVUQ6x0tWez4FREozTslMxqKFfJ6jGGa_kYzqfH3ycnvC-pwB3Z7RWXeUWQJ0EsMLPKq8oXlcpzpEdLMvbUTgostbSJspUoK6Fs7AsrkhQTn1rxBHabRYPPgFmFNAAW0iNKnYXa6TKTReqUk6WIbQTxsMTG9fnGQ9mLmWnvvYU2HVcMccUErpg4grdjl8su2cZNxPsD30yvd0tDACTTGUHSJILXYzNpTLgGoUVarImGdrmF0rSXu4FGkGFXIXt-BE87URhnJAhUC9o3R5BvCMlIEDJ2b7Y09Y82c3cmFeHRPIJ3gzhdT_2fH_r8v6hfwd1vR1Pz5dPZ5xdwL21FXvJY78Pu6ucaDwhCrezLVmH-AAUpFuc
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genome-wide+meta-analysis+identifies+multiple+novel+loci+associated+with+serum+uric+acid+levels+in+Japanese+individuals&rft.jtitle=Communications+biology&rft.au=Nakatochi%2C+Masahiro&rft.au=Kanai%2C+Masahiro&rft.au=Nakayama%2C+Akiyoshi&rft.au=Hishida%2C+Asahi&rft.date=2019-04-08&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2399-3642&rft.volume=2&rft_id=info:doi/10.1038%2Fs42003-019-0339-0&rft_id=info%3Apmid%2F30993211&rft.externalDocID=PMC6453927
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2399-3642&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2399-3642&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2399-3642&client=summon