The plasma membrane redox system in human platelet functions and platelet-leukocyte interactions

• Published in: Thrombosis and haemostasis Vol. 101; no. 2; p. 284
• Main Authors: Del Principe, Domenico, Frega, Gianluca, Savini, Isabella, Catani, M Valeria, Rossi, Antonello, Avigliano, Luciana
• Format: Journal Article
• Language: English
• Published: Germany 01.02.2009
• Subjects: Antioxidants - metabolism; Blood Coagulation; Blood Platelets - metabolism; Cell Membrane - metabolism; Electron Transport; Humans; Leukocytes - metabolism; Oxidation-Reduction; Platelet Activation; Reactive Oxygen Species - blood; Signal Transduction; Thrombosis - blood

The plasma membrane electron transport is crucial for blood coagulation and thrombosis, since reactive oxygen species and thiol changes, generated by plasma membrane redox reactions, modulate activation of platelets, as well as their interaction with leukocytes. Several antioxidants are linked to th...