The plasma membrane redox system in human platelet functions and platelet-leukocyte interactions

The plasma membrane electron transport is crucial for blood coagulation and thrombosis, since reactive oxygen species and thiol changes, generated by plasma membrane redox reactions, modulate activation of platelets, as well as their interaction with leukocytes. Several antioxidants are linked to th...

Full description

Saved in:
Bibliographic Details
Published inThrombosis and haemostasis Vol. 101; no. 2; p. 284
Main Authors Del Principe, Domenico, Frega, Gianluca, Savini, Isabella, Catani, M Valeria, Rossi, Antonello, Avigliano, Luciana
Format Journal Article
LanguageEnglish
Published Germany 01.02.2009
Subjects
Antioxidants - metabolism
Blood Coagulation
Blood Platelets - metabolism
Cell Membrane - metabolism
Electron Transport
Humans
Leukocytes - metabolism
Oxidation-Reduction
Platelet Activation
Reactive Oxygen Species - blood
Signal Transduction
Thrombosis - blood
Online AccessGet more information

Cover

More Information
Summary:The plasma membrane electron transport is crucial for blood coagulation and thrombosis, since reactive oxygen species and thiol changes, generated by plasma membrane redox reactions, modulate activation of platelets, as well as their interaction with leukocytes. Several antioxidants are linked to this system; thus, platelets are also able to counterbalance radical production and to regulate thrombus growth. Aim of this review is to give an update on the plasma membrane redox system in platelets, as well as on its role in platelet functions and leukocyte-platelet cross-talk.
ISSN:0340-6245
DOI:10.1160/TH08-05-0300