Uncovering a conserved vulnerability site in SARS‐CoV‐2 by a human antibody

• Published in: EMBO molecular medicine Vol. 13; no. 12; pp. e14544 - n/a
• Main Authors: Li, Tingting, Cai, Hongmin, Zhao, Yapei, Li, Yanfang, Lai, Yanling, Yao, Hebang, Liu, Liu Daisy, Sun, Zhou, van Vlissingen, Martje Fentener, Kuiken, Thijs, GeurtsvanKessel, Corine H, Zhang, Ning, Zhou, Bingjie, Lu, Lu, Gong, Yuhuan, Qin, Wenming, Mondal, Moumita, Duan, Bowen, Xu, Shiqi, Richard, Audrey S, Raoul, Hervé, Chen, JianFeng, Xu, Chenqi, Wu, Ligang, Zhou, Haisheng, Huang, Zhong, Zhang, Xuechao, Li, Jun, Wang, Yanyan, Bi, Yuhai, Rockx, Barry, Chen, Junfang, Meng, Fei‐Long, Lavillette, Dimitri, Li, Dianfan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.12.2021; EMBO Press; Wiley Open Access; John Wiley and Sons Inc; Springer Nature
• Subjects: Antibodies, Viral; Antiviral agents; Antiviral drugs; Binding sites; Chromatography; Coronaviruses; COVID-19; COVID-19 vaccines; cross‐active neutralizing antibody; destruction of spike; Drug development; Electron microscopy; EMBO23; EMBO40; Emerging diseases; Epitopes; Human health and pathology; Humans; Immunology; Immunotherapy; Infectious diseases; Life Sciences; Microbiology and Parasitology; Monoclonal antibodies; Mutagenesis; Mutation; Pulmonology and respiratory tract; receptor‐binding domain; RNA polymerase; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus; Structure-function relationships; variants of concern; Virology; cross‐active neutralizing antibody; COVID‐19; variants of concern; destruction of spike; receptor‐binding domain; COVID-19; cross-active neutralizing antibody; receptor-binding domain; Destruction of spike; Variants of concern; Cross-active neutralizing antibody; Receptor-binding domain

An essential step for SARS‐CoV‐2 infection is the attachment to the host cell receptor by its Spike receptor‐binding domain (RBD). Most of the existing RBD‐targeting neutralizing antibodies block the receptor‐binding motif (RBM), a mutable region with the potential to generate neutralization escape...