Local actin nucleation tunes centrosomal microtubule nucleation during passage through mitosis

• Published in: The EMBO journal Vol. 38; no. 11
• Main Authors: Farina, Francesca, Ramkumar, Nitya, Brown, Louise, Samandar Eweis, Dureen, Anstatt, Jannis, Waring, Thomas, Bithell, Jessica, Scita, Giorgio, Thery, Manuel, Blanchoin, Laurent, Zech, Tobias, Baum, Buzz
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.06.2019; Springer Nature B.V; EMBO Press; John Wiley and Sons Inc
• Subjects: Actin; Actin Cytoskeleton - metabolism; Actins - metabolism; Anaphase; Arp2/3 complex; Cell size; Cells, Cultured; Cellular Biology; Cellular structure; centrosomal actin; Centrosome - metabolism; Centrosomes; Crosstalk; Cytoskeleton; Cytoskeleton - metabolism; Density; EMBO05; EMBO06; Filaments; HeLa Cells; Humans; In vivo methods and tests; Interphase; Interphase - physiology; Jurkat Cells; Life Sciences; Microtubules; Microtubules - metabolism; Mitosis; Mitosis - physiology; Nucleation; Protein Multimerization - physiology; Reduction; WASH complex; Arp2/3 complex; centrosomal actin; WASH complex; mitosis; WASH complex Subject Categories Cell Adhesion; Cell Cycle; Polarity & Cytoskeleton
• ISSN: 0261-4189; 1460-2075; 1460-2075
• DOI: 10.15252/embj.201899843

Cells going through mitosis undergo precisely timed changes in cell shape and organisation, which serve to ensure the fair partitioning of cellular components into the two daughter cells. These structural changes are driven by changes in actin filament and microtubule dynamics and organisation. Whil...