Targeting-Triggered Porphysome Nanostructure Disruption for Activatable Photodynamic Therapy

• Published in: Advanced healthcare materials Vol. 3; no. 8; pp. 1240 - 1249
• Main Authors: Jin, Cheng S., Cui, Liyang, Wang, Fan, Chen, Juan, Zheng, Gang
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 01.08.2014; Wiley Subscription Services, Inc
• Subjects: Ablation; Animals; Cell Line, Tumor; Cell Survival - drug effects; Disruption; Endocytosis; folate receptor; Folate Receptors, GPI-Anchored - genetics; Folate Receptors, GPI-Anchored - metabolism; Folic Acid - chemistry; Formulations; Humans; Lasers; Mice; Mice, Nude; nanoparticles; Nanostructure; Nanostructures - chemistry; Neoplasms - drug therapy; Neoplasms - mortality; Neoplasms - pathology; Oxygen; Photochemotherapy; Photodynamic therapy; photosensitizer; Photosensitizing Agents - administration & dosage; Photosensitizing Agents - chemistry; Photosensitizing Agents - toxicity; porphyrin; Porphyrins; Porphyrins - chemistry; porphysomes; Singlet oxygen; Singlet Oxygen - metabolism; Survival Rate; Switching; Therapy; Transplantation, Heterologous; folate receptor; nanoparticles; porphyrin; photosensitizer; porphysomes
• ISSN: 2192-2640; 2192-2659; 2192-2659
• DOI: 10.1002/adhm.201300651

Photodynamic therapy (PDT) and photothermal therapy (PTT) possess advantages over the conventional therapies with additional treatment selectivity achieved with local laser irradiation. Comparing to PTT that ablates target tissue via thermal necrosis, PDT induces target cell death via singlet oxygen...