An ATR‐dependent function for the Ddx19 RNA helicase in nuclear R‐loop metabolism

• Published in: The EMBO journal Vol. 36; no. 9; pp. 1182 - 1198
• Main Authors: Hodroj, Dana, Recolin, Bénédicte, Serhal, Kamar, Martinez, Susan, Tsanov, Nikolay, Abou Merhi, Raghida, Maiorano, Domenico
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.05.2017; Blackwell Publishing Ltd; EMBO Press; John Wiley and Sons Inc
• Subjects: Animals; Ataxia Telangiectasia Mutated Proteins - metabolism; camptothecin; Checkpoint Kinase 1 - metabolism; Chk1; Damage accumulation; DEAD-box RNA Helicases - metabolism; Deoxyribonucleic acid; Depletion; DNA; DNA Damage; DNA Repair; EMBO13; EMBO36; Exports; Genetics; Genomes; Hybrids; Integrity; Life Sciences; Maintenance; Metabolism; Mutation; Nuclei (cytology); Replication; replication stress; Ribonucleic acid; RNA; RNA - metabolism; Signal transduction; Translocation; Xenopus; Xenopus - metabolism; Xenopus Proteins - metabolism; replication stress; Chk1; camptothecin; DNA damage; Xenopus

Coordination between transcription and replication is crucial in the maintenance of genome integrity. Disturbance of these processes leads to accumulation of aberrant DNA:RNA hybrids (R‐loops) that, if unresolved, generate DNA damage and genomic instability. Here we report a novel, unexpected role f...