脑白质高信号与帕金森病认知功能障碍研究进展

帕金森病是中老年人群常见的神经变性病,认知功能障碍是其最常见的非运动症状,严重影响患者生活质量。认知功能障碍与多种因素有关,如脑白质高信号,且脑白质高信号是帕金森病认知功能障碍的重要病理改变。本文从神经元通路、脑白质体积变化和扩散张量成像方面阐述脑白质高信号与帕金森病认知功能障碍之间的关系,为早期诊断帕金森病提供新的方向。...

Full description

Saved in:
Bibliographic Details
Published in中国现代神经疾病杂志 Vol. 17; no. 11; pp. 846 - 850
Main Author 胡方方;张尊胜;杨新新
Format Journal Article
LanguageChinese
Published 221002,徐州医科大学附属医院神经内科 2017
Subjects
帕金森病
磁共振成像
综述
认知障碍
磁共振成像
Magnetic resonance imaging
帕金森病
Parkinson disease
综述
Cognition disorders
Review
认知障碍
Online AccessGet full text
ISSN1672-6731
DOI10.3969/j.issn.1672-6731.2017.11.012

Cover

More Information
Summary:帕金森病是中老年人群常见的神经变性病,认知功能障碍是其最常见的非运动症状,严重影响患者生活质量。认知功能障碍与多种因素有关,如脑白质高信号,且脑白质高信号是帕金森病认知功能障碍的重要病理改变。本文从神经元通路、脑白质体积变化和扩散张量成像方面阐述脑白质高信号与帕金森病认知功能障碍之间的关系,为早期诊断帕金森病提供新的方向。
Bibliography:I-IU Fang-fang, ZHANG Zun-sheng, YANG Xin-xin（ Department of Neurology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu, China）
Parkinson＇s disease（PD） is a common neurodegenerative disease in the elderly, of which cognitive impairment is the most common non.motor symptom（NMS） affecting the life quality of patients.Cognitive impairment is associated with many factors, and white matter hyperintensity（WMH） is an important pathological change of cognitive impairment in PD. In this paper, we will explain the relationship between WMH and cognitive impairment in PD by the perspective of neuronal pathway, white matter volume change and diffusion tensor imaging（DTI）, to provide a new direction for the early diagnosis of PD.
Parkinson disease; Cognition disorders; Magnetic resonance imaging; Review
12-1363/R
ISSN:1672-6731
DOI:10.3969/j.issn.1672-6731.2017.11.012