脑白质高信号与帕金森病认知功能障碍研究进展
帕金森病是中老年人群常见的神经变性病,认知功能障碍是其最常见的非运动症状,严重影响患者生活质量。认知功能障碍与多种因素有关,如脑白质高信号,且脑白质高信号是帕金森病认知功能障碍的重要病理改变。本文从神经元通路、脑白质体积变化和扩散张量成像方面阐述脑白质高信号与帕金森病认知功能障碍之间的关系,为早期诊断帕金森病提供新的方向。...
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| Published in | 中国现代神经疾病杂志 Vol. 17; no. 11; pp. 846 - 850 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
221002,徐州医科大学附属医院神经内科
2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1672-6731 |
| DOI | 10.3969/j.issn.1672-6731.2017.11.012 |
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| Abstract | 帕金森病是中老年人群常见的神经变性病,认知功能障碍是其最常见的非运动症状,严重影响患者生活质量。认知功能障碍与多种因素有关,如脑白质高信号,且脑白质高信号是帕金森病认知功能障碍的重要病理改变。本文从神经元通路、脑白质体积变化和扩散张量成像方面阐述脑白质高信号与帕金森病认知功能障碍之间的关系,为早期诊断帕金森病提供新的方向。 |
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| AbstractList | 帕金森病是中老年人群常见的神经变性病,认知功能障碍是其最常见的非运动症状,严重影响患者生活质量.认知功能障碍与多种因素有关,如脑白质高信号,且脑白质高信号是帕金森病认知功能障碍的重要病理改变.本文从神经元通路、脑白质体积变化和扩散张量成像方面阐述脑白质高信号与帕金森病认知功能障碍之间的关系,为早期诊断帕金森病提供新的方向. |
| Abstract_FL | Parkinson's disease (PD) is a common neurodegenerative disease in the elderly,of which cognitive impairment is the most common non-motor symptom (NMS) affecting the life quality of patients.Cognitive impairment is associated with many factors,and white matter hyperintensity (WMH) is an important pathological change of cognitive impairment in PD.In this paper,we will explain the relationship between WMH and cognitive impairment in PD by the perspective of neuronal pathway,white matter volume change and diffusion tensor imaging (DTI),to provide a new direction for the early diagnosis of PD. |
| Author | 胡方方;张尊胜;杨新新 |
| AuthorAffiliation | 徐州医科大学附属医院神经内科,221002 |
| AuthorAffiliation_xml | – name: 221002,徐州医科大学附属医院神经内科 |
| Author_FL | YANG Xin-xin HU Fang-fang ZHANG Zun-sheng |
| Author_FL_xml | – sequence: 1 fullname: HU Fang-fang – sequence: 2 fullname: ZHANG Zun-sheng – sequence: 3 fullname: YANG Xin-xin |
| Author_xml | – sequence: 1 fullname: 胡方方;张尊胜;杨新新 |
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| DOI | 10.3969/j.issn.1672-6731.2017.11.012 |
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| DocumentTitleAlternate | Research progress of relationship between white matter hyperintensity and cognitive impairment in Parkinson＇s disease |
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| EndPage | 850 |
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| Keywords | 磁共振成像 Magnetic resonance imaging 帕金森病 Parkinson disease 综述 Cognition disorders Review 认知障碍 |
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| Notes | I-IU Fang-fang, ZHANG Zun-sheng, YANG Xin-xin（ Department of Neurology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu, China） Parkinson＇s disease（PD） is a common neurodegenerative disease in the elderly, of which cognitive impairment is the most common non.motor symptom（NMS） affecting the life quality of patients.Cognitive impairment is associated with many factors, and white matter hyperintensity（WMH） is an important pathological change of cognitive impairment in PD. In this paper, we will explain the relationship between WMH and cognitive impairment in PD by the perspective of neuronal pathway, white matter volume change and diffusion tensor imaging（DTI）, to provide a new direction for the early diagnosis of PD. Parkinson disease; Cognition disorders; Magnetic resonance imaging; Review 12-1363/R |
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| PublicationTitle | 中国现代神经疾病杂志 |
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| Publisher | 221002,徐州医科大学附属医院神经内科 |
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| SubjectTerms | 帕金森病 磁共振成像 综述 认知障碍 |
| Title | 脑白质高信号与帕金森病认知功能障碍研究进展 |
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