The Function of SUMOylation and Its Role in the Development of Cancer Cells under Stress Conditions: A Systematic Review

• Published in: Stem cells international Vol. 2020; no. 2020; pp. 1 - 16
• Main Authors: Zheng, Minying, Zhang, Kexin, Li, Zugui, Ma, Ying, Zhao, Qi, Zhang, Shiwu
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; John Wiley & Sons, Inc; Hindawi Limited; Wiley
• Subjects: Amino acids; Angiogenesis; B cells; Canada; Cancer; Cancer cells; Care and treatment; Cell proliferation; Chemoradiotherapy; China; Competition; Deoxyribonucleic acid; Development and progression; DNA; DNA repair; Drug development; Enzymes; Health aspects; Health risks; Kinases; Mammals; Metabolism; Metastases; Morbidity; Mortality; Phosphorylation; Physiology; Post-translational modification; Prognosis; Proteases; Protein biosynthesis; Protein synthesis; Protein turnover; Proteins; Radiation; Review; Stresses; SUMO protein; Tumor cells; Tumor suppressor genes; Tumors; Ubiquitin; Canada; China

Malignant tumors still pose serious threats to human health due to their high morbidity and mortality. Recurrence and metastasis are the most important factors affecting patient prognosis. Chemotherapeutic drugs and radiation used to treat these tumors mainly interfere with tumor metabolism, destroy...