Correlation between Reduced FEF25-75% and a Positive Methacholine Challenge Test in Adults with Nonobstructive Baseline Spirometry

• Published in: Pulmonary medicine Vol. 2021; pp. 6959322 - 5
• Main Authors: Shafiq, Irfan, Uzbeck, Mateen Haider, Zoumot, Zaid, Abuzakouk, Mohamed, Parappurath, Niyas, Wahla, Ali Saeed
• Format: Journal Article
• Language: English
• Published: Egypt Hindawi 29.12.2021; John Wiley & Sons, Inc; Hindawi Limited; Wiley
• Subjects: Adult; Adults; Age; Airway management; Asthma; Asthma - diagnosis; Asthma in children; Bronchial Provocation Tests - methods; Female; Females; Forced Expiratory Volume - drug effects; Gender; Humans; Male; Methacholine; Methacholine Chloride; Middle Aged; Patients; Probability; Retrospective Studies; Spirometry

Rationale. FEF25-75% is routinely reported on spirometry and is thought to be a marker of small airway obstruction. It is reduced in children with asthma, but its significance in adults and especially those without asthma diagnosis remains unclear. Objective. To clarify whether in adults with a nono...