Pathological circuit function underlying addiction and anxiety disorders

• Published in: Nature neuroscience Vol. 17; no. 12; pp. 1635 - 1643
• Main Authors: Luthi, Andreas, Luscher, Christian
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.12.2014; Nature Publishing Group
• Subjects: 14; 631/1647/2253; 631/378/1689/1300; 692/699/476/5; 9/74; Addiction; Addictions; Addictive behaviors; Animal Genetics and Genomics; Animals; Anxiety; Anxiety disorders; Anxiety Disorders - diagnosis; Anxiety Disorders - physiopathology; Anxiety Disorders - psychology; Behavior; Behavior, Addictive - diagnosis; Behavior, Addictive - physiopathology; Behavior, Addictive - psychology; Behavioral Sciences; Biological Techniques; Biomedicine; Brain - pathology; Brain - physiology; Brain research; Disease; Drug use; Humans; Neurobiology; Neurological research; Neuronal Plasticity - physiology; Neurophysiology; Neurosciences; review-article; Switzerland

In this Review, Lüscher and Lüthi draw some parallels between anxiety and addiction disorders as diseases of the brain's emotional valence system. The authors present an update on the anatomy and heterogeneity of the fear and reward circuitries, analyze our understanding of the synaptic and cel...