Scutellarin Loaded on Ultradeformable Nanoliposome Scutellarin EDTMP (S-UNL-E) Promotes Osteogenesis in Osteoporotic Rats
Scutellarin is known as a safe, effective, and low-cost traditional Chinese medicine and has a variety of biological activities. Studies reported that the scutellarin loaded on ultradeformable nanoliposome scutellarin EDTMP (S-UNL-E) could promote osteoblast differentiation and bone formation in vit...
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| Published in | Stem cells international Vol. 2022; pp. 1 - 10 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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United States
Hindawi
16.08.2022
John Wiley & Sons, Inc Wiley |
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| Abstract | Scutellarin is known as a safe, effective, and low-cost traditional Chinese medicine and has a variety of biological activities. Studies reported that the scutellarin loaded on ultradeformable nanoliposome scutellarin EDTMP (S-UNL-E) could promote osteoblast differentiation and bone formation in vitro. However, its effect on promoting osteogenesis in vivo is still unclear. In this study, pharmacology network and transcriptome sequencing were used to screen the potential targets and pathways of scutellarin in treating osteoporosis. The female Sprague-Dawley (SD) rats were operated on with bilateral oophorectomy and femoral defect to establish an osteoporosis model and then treated separately with bone dust, single scutellarin, 40 mg/kg ultradeformable nanoliposome scutellarin (S-UNL), and the optimal concentration of 40 mg/kg S-UNL-E for a total of 56 d to detect the parameters of trabecular bones. And qRT-PCR and western blot were performed to determine the expression of prostaglandin-endoperoxide synthase 2 (PTGS2), alkaline phosphatase (ALP), transcription factor 4 (TCF4), and β-catenin. Results of microscopic computed tomography (Micro-CT) of trabecular bones showed that single scutellarin, S-UNL, and S-UNL-E all promoted the bone formation of osteoporotic rats, in which S-UNL-E manifested the most remarkable therapeutic effect. And it is found that 40 mg/kg of S-UNL-E increased the expression of PTGS2, ALP, TCF4, and β-catenin, which indicated that S-UNL-E stimulated the secretion of ALP in bone defect areas to promote bone healing, and increased PTGS2 expression thereby enhancing the transcription and translation of key gene β-catenin and TCF4 in the Wnt/β-catenin signaling pathway to treat osteoporotic rats. |
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| AbstractList | Scutellarin is known as a safe, effective, and low-cost traditional Chinese medicine and has a variety of biological activities. Studies reported that the scutellarin loaded on ultradeformable nanoliposome scutellarin EDTMP (S-UNL-E) could promote osteoblast differentiation and bone formation in vitro. However, its effect on promoting osteogenesis in vivo is still unclear. In this study, pharmacology network and transcriptome sequencing were used to screen the potential targets and pathways of scutellarin in treating osteoporosis. The female Sprague-Dawley (SD) rats were operated on with bilateral oophorectomy and femoral defect to establish an osteoporosis model and then treated separately with bone dust, single scutellarin, 40mg/kg ultradeformable nanoliposome scutellarin (S-UNL), and the optimal concentration of 40mg/kgS-UNL-E for a total of 56d to detect the parameters of trabecular bones. And qRT-PCR and western blot were performed to determine the expression of prostaglandin-endoperoxide synthase 2 (PTGS2), alkaline phosphatase (ALP), transcription factor 4 (TCF4), and β -catenin. Results of microscopic computed tomography (Micro-CT) of trabecular bones showed that single scutellarin, S-UNL, and S-UNL-E all promoted the bone formation of osteoporotic rats, in which S-UNL-E manifested the most remarkable therapeutic effect. And it is found that 40mg/kg of S-UNL-E increased the expression of PTGS2, ALP, TCF4, and β -catenin, which indicated that S-UNL-E stimulated the secretion of ALP in bone defect areas to promote bone healing, and increased PTGS2 expression thereby enhancing the transcription and translation of key gene β -catenin and TCF4 in the Wnt/β -catenin signaling pathway to treat osteoporotic rats. Scutellarin is known as a safe, effective, and low-cost traditional Chinese medicine and has a variety of biological activities. Studies reported that the scutellarin loaded on ultradeformable nanoliposome scutellarin EDTMP (S-UNL-E) could promote osteoblast differentiation and bone formation in vitro. However, its effect on promoting osteogenesis in vivo is still unclear. In this study, pharmacology network and transcriptome sequencing were used to screen the potential targets and pathways of scutellarin in treating osteoporosis. The female Sprague-Dawley (SD) rats were operated on with bilateral oophorectomy and femoral defect to establish an osteoporosis model and then treated separately with bone dust, single scutellarin, 40 mg/kg ultradeformable nanoliposome scutellarin (S-UNL), and the optimal concentration of 40 mg/kg S-UNL-E for a total of 56 d to detect the parameters of trabecular bones. And qRT-PCR and western blot were performed to determine the expression of prostaglandin-endoperoxide synthase 2 (PTGS2), alkaline phosphatase (ALP), transcription factor 4 (TCF4), and β-catenin. Results of microscopic computed tomography (Micro-CT) of trabecular bones showed that single scutellarin, S-UNL, and S-UNL-E all promoted the bone formation of osteoporotic rats, in which S-UNL-E manifested the most remarkable therapeutic effect. And it is found that 40 mg/kg of S-UNL-E increased the expression of PTGS2, ALP, TCF4, and β-catenin, which indicated that S-UNL-E stimulated the secretion of ALP in bone defect areas to promote bone healing, and increased PTGS2 expression thereby enhancing the transcription and translation of key gene β-catenin and TCF4 in the Wnt/β-catenin signaling pathway to treat osteoporotic rats.Scutellarin is known as a safe, effective, and low-cost traditional Chinese medicine and has a variety of biological activities. Studies reported that the scutellarin loaded on ultradeformable nanoliposome scutellarin EDTMP (S-UNL-E) could promote osteoblast differentiation and bone formation in vitro. However, its effect on promoting osteogenesis in vivo is still unclear. In this study, pharmacology network and transcriptome sequencing were used to screen the potential targets and pathways of scutellarin in treating osteoporosis. The female Sprague-Dawley (SD) rats were operated on with bilateral oophorectomy and femoral defect to establish an osteoporosis model and then treated separately with bone dust, single scutellarin, 40 mg/kg ultradeformable nanoliposome scutellarin (S-UNL), and the optimal concentration of 40 mg/kg S-UNL-E for a total of 56 d to detect the parameters of trabecular bones. And qRT-PCR and western blot were performed to determine the expression of prostaglandin-endoperoxide synthase 2 (PTGS2), alkaline phosphatase (ALP), transcription factor 4 (TCF4), and β-catenin. Results of microscopic computed tomography (Micro-CT) of trabecular bones showed that single scutellarin, S-UNL, and S-UNL-E all promoted the bone formation of osteoporotic rats, in which S-UNL-E manifested the most remarkable therapeutic effect. And it is found that 40 mg/kg of S-UNL-E increased the expression of PTGS2, ALP, TCF4, and β-catenin, which indicated that S-UNL-E stimulated the secretion of ALP in bone defect areas to promote bone healing, and increased PTGS2 expression thereby enhancing the transcription and translation of key gene β-catenin and TCF4 in the Wnt/β-catenin signaling pathway to treat osteoporotic rats. Scutellarin is known as a safe, effective, and low-cost traditional Chinese medicine and has a variety of biological activities. Studies reported that the scutellarin loaded on ultradeformable nanoliposome scutellarin EDTMP (S-UNL-E) could promote osteoblast differentiation and bone formation in vitro. However, its effect on promoting osteogenesis in vivo is still unclear. In this study, pharmacology network and transcriptome sequencing were used to screen the potential targets and pathways of scutellarin in treating osteoporosis. The female Sprague-Dawley (SD) rats were operated on with bilateral oophorectomy and femoral defect to establish an osteoporosis model and then treated separately with bone dust, single scutellarin, 40 mg/kg ultradeformable nanoliposome scutellarin (S-UNL), and the optimal concentration of 40 mg/kg S-UNL-E for a total of 56 d to detect the parameters of trabecular bones. And qRT-PCR and western blot were performed to determine the expression of prostaglandin-endoperoxide synthase 2 (PTGS2), alkaline phosphatase (ALP), transcription factor 4 (TCF4), and β -catenin. Results of microscopic computed tomography (Micro-CT) of trabecular bones showed that single scutellarin, S-UNL, and S-UNL-E all promoted the bone formation of osteoporotic rats, in which S-UNL-E manifested the most remarkable therapeutic effect. And it is found that 40 mg/kg of S-UNL-E increased the expression of PTGS2, ALP, TCF4, and β -catenin, which indicated that S-UNL-E stimulated the secretion of ALP in bone defect areas to promote bone healing, and increased PTGS2 expression thereby enhancing the transcription and translation of key gene β -catenin and TCF4 in the Wnt/ β -catenin signaling pathway to treat osteoporotic rats. Scutellarin is known as a safe, effective, and low-cost traditional Chinese medicine and has a variety of biological activities. Studies reported that the scutellarin loaded on ultradeformable nanoliposome scutellarin EDTMP (S-UNL-E) could promote osteoblast differentiation and bone formation in vitro. However, its effect on promoting osteogenesis in vivo is still unclear. In this study, pharmacology network and transcriptome sequencing were used to screen the potential targets and pathways of scutellarin in treating osteoporosis. The female Sprague-Dawley (SD) rats were operated on with bilateral oophorectomy and femoral defect to establish an osteoporosis model and then treated separately with bone dust, single scutellarin, 40 mg/kg ultradeformable nanoliposome scutellarin (S-UNL), and the optimal concentration of 40 mg/kg S-UNL-E for a total of 56 d to detect the parameters of trabecular bones. And qRT-PCR and western blot were performed to determine the expression of prostaglandin-endoperoxide synthase 2 (PTGS2), alkaline phosphatase (ALP), transcription factor 4 (TCF4), and β-catenin. Results of microscopic computed tomography (Micro-CT) of trabecular bones showed that single scutellarin, S-UNL, and S-UNL-E all promoted the bone formation of osteoporotic rats, in which S-UNL-E manifested the most remarkable therapeutic effect. And it is found that 40 mg/kg of S-UNL-E increased the expression of PTGS2, ALP, TCF4, and β-catenin, which indicated that S-UNL-E stimulated the secretion of ALP in bone defect areas to promote bone healing, and increased PTGS2 expression thereby enhancing the transcription and translation of key gene β-catenin and TCF4 in the Wnt/β-catenin signaling pathway to treat osteoporotic rats. Scutellarin is known as a safe, effective, and low-cost traditional Chinese medicine and has a variety of biological activities. Studies reported that the scutellarin loaded on ultradeformable nanoliposome scutellarin EDTMP (S-UNL-E) could promote osteoblast differentiation and bone formation in vitro. However, its effect on promoting osteogenesis in vivo is still unclear. In this study, pharmacology network and transcriptome sequencing were used to screen the potential targets and pathways of scutellarin in treating osteoporosis. The female Sprague-Dawley (SD) rats were operated on with bilateral oophorectomy and femoral defect to establish an osteoporosis model and then treated separately with bone dust, single scutellarin, 40 mg/kg ultradeformable nanoliposome scutellarin (S-UNL), and the optimal concentration of 40 mg/kg S-UNL-E for a total of 56 d to detect the parameters of trabecular bones. And qRT-PCR and western blot were performed to determine the expression of prostaglandin-endoperoxide synthase 2 (PTGS2), alkaline phosphatase (ALP), transcription factor 4 (TCF4), and -catenin. Results of microscopic computed tomography (Micro-CT) of trabecular bones showed that single scutellarin, S-UNL, and S-UNL-E all promoted the bone formation of osteoporotic rats, in which S-UNL-E manifested the most remarkable therapeutic effect. And it is found that 40 mg/kg of S-UNL-E increased the expression of PTGS2, ALP, TCF4, and -catenin, which indicated that S-UNL-E stimulated the secretion of ALP in bone defect areas to promote bone healing, and increased PTGS2 expression thereby enhancing the transcription and translation of key gene -catenin and TCF4 in the Wnt/ -catenin signaling pathway to treat osteoporotic rats. |
| Audience | Academic |
| Author | Zhao, Baodong Gao, Hui Teng, Minhua Wang, Dashan Yuan, Xiao Wang, Wenxue Zhang, Kaiyue |
| AuthorAffiliation | 2 School of Stomatology, Qingdao University, Qingdao 266003, China 3 Department of Orthodontics, The Affiliated Hospital of Qingdao University, Qingdao 266000, China 1 Department of Oral Implantology, The Affiliated Hospital of Qingdao University, Qingdao 266000, China |
| AuthorAffiliation_xml | – name: 1 Department of Oral Implantology, The Affiliated Hospital of Qingdao University, Qingdao 266000, China – name: 2 School of Stomatology, Qingdao University, Qingdao 266003, China – name: 3 Department of Orthodontics, The Affiliated Hospital of Qingdao University, Qingdao 266000, China |
| Author_xml | – sequence: 1 givenname: Minhua orcidid: 0000-0001-8148-8500 surname: Teng fullname: Teng, Minhua organization: Department of Oral ImplantologyThe Affiliated Hospital of Qingdao UniversityQingdao 266000Chinaqdu.edu.cn – sequence: 2 givenname: Xiao orcidid: 0000-0003-3590-1805 surname: Yuan fullname: Yuan, Xiao organization: School of StomatologyQingdao UniversityQingdao 266003Chinaqdu.edu.cn – sequence: 3 givenname: Dashan surname: Wang fullname: Wang, Dashan organization: Department of Oral ImplantologyThe Affiliated Hospital of Qingdao UniversityQingdao 266000Chinaqdu.edu.cn – sequence: 4 givenname: Hui surname: Gao fullname: Gao, Hui organization: Department of Oral ImplantologyThe Affiliated Hospital of Qingdao UniversityQingdao 266000Chinaqdu.edu.cn – sequence: 5 givenname: Kaiyue surname: Zhang fullname: Zhang, Kaiyue organization: Department of Oral ImplantologyThe Affiliated Hospital of Qingdao UniversityQingdao 266000Chinaqdu.edu.cn – sequence: 6 givenname: Wenxue surname: Wang fullname: Wang, Wenxue organization: Department of Oral ImplantologyThe Affiliated Hospital of Qingdao UniversityQingdao 266000Chinaqdu.edu.cn – sequence: 7 givenname: Baodong orcidid: 0000-0001-8847-3408 surname: Zhao fullname: Zhao, Baodong organization: Department of Oral ImplantologyThe Affiliated Hospital of Qingdao UniversityQingdao 266000Chinaqdu.edu.cn |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36017130$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_3389_fphar_2023_1329969 crossref_primary_10_1155_2023_9851693 crossref_primary_10_1016_j_bioorg_2024_108020 |
| Cites_doi | 10.1016/j.ebiom.2020.102626 10.1016/j.jsbmb.2013.09.008 10.1002/jbm.a.34642 10.1021/acs.jafc.5b06132 10.1016/j.tice.2021.101553 10.1074/jbc.M111.250985 10.1016/S0166-4328(01)00297-2 10.1080/21655979.2021.2016095 10.1093/bioinformatics/btp616 10.26355/eurrev_201911_19534 10.4103/0366-6999.244111 10.1016/j.intimp.2016.09.031 10.1507/endocrj.EJ16-0003 10.14670/HH-11-651 10.1016/j.etp.2012.05.003 10.1007/s12031-015-0565-y 10.1016/j.gene.2018.06.068 10.3109/10428194.2012.693177 10.1186/gb-2010-11-3-r25 10.1002/jor.23553 10.1038/nmeth.1226 10.1016/j.ejphar.2018.10.051 10.1007/s11914-014-0197-0 10.7326/M15-1361 10.2174/1381612823666170220155540 |
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| Copyright | Copyright © 2022 Minhua Teng et al. COPYRIGHT 2022 John Wiley & Sons, Inc. Copyright © 2022 Minhua Teng et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0 Copyright © 2022 Minhua Teng et al. 2022 |
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| References | 22 23 24 25 26 10 11 12 13 14 15 H. Guo (3) 2011; 54 16 17 18 19 1 2 4 5 6 7 8 9 20 21 38152722 - Stem Cells Int. 2023 Dec 20;2023:9851693 |
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| SubjectTerms | Alkaline phosphatase Bone growth Bone healing Bones Computed tomography Defects Drug delivery systems Drugs Genes Genetic translation Herbal medicine In vivo methods and tests Osteoblastogenesis Osteogenesis Osteoporosis Ovariectomy Pharmacology Phosphonates Prostaglandin endoperoxide synthase Quantitative analysis Signal transduction Traditional Chinese medicine Transcriptomes Wnt protein β-Catenin |
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| Title | Scutellarin Loaded on Ultradeformable Nanoliposome Scutellarin EDTMP (S-UNL-E) Promotes Osteogenesis in Osteoporotic Rats |
| URI | https://dx.doi.org/10.1155/2022/1395299 https://www.ncbi.nlm.nih.gov/pubmed/36017130 https://www.proquest.com/docview/2707457804 https://www.proquest.com/docview/2707603203 https://pubmed.ncbi.nlm.nih.gov/PMC9398854 https://doaj.org/article/4f3783ccef174207aa23b1c37d456058 |
| Volume | 2022 |
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