Interleukin-10 Induces Expression of Neuroendocrine Markers and PDL1 in Prostate Cancer Cells

• Published in: Prostate cancer Vol. 2020; no. 2020; pp. 1 - 12
• Main Authors: Chamberlain, Thomas C., Zoubeidi, Amina, Ong, Christopher J., Yoon, Jeff S. J., Samiea, Abrar, Mui, Alice L.-F.
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; Hindawi Limited; Wiley
• Subjects: Androgens; Antibodies; Biotechnology; Cancer cells; Cancer therapies; Cancer treatment; Cytokines; EDTA; Enzalutamide; Flow cytometry; Health aspects; Immune response; Interleukins; Prognosis; Prostate cancer; Tumors; Canada; Santa Barbara California; Vancouver British Columbia Canada; Utah

Interleukin-10 (IL10) is best studied for its inhibitory action on immune cells and ability to suppress an antitumour immune response. But IL10 also exerts direct effects on nonimmune cells such as prostate cancer epithelial cells. Elevated serum levels of IL10 observed in prostate and other cancer...