Astrocytes gate Hebbian synaptic plasticity in the striatum

• Published in: Nature communications Vol. 7; no. 1; p. 13845
• Main Authors: Valtcheva, Silvana, Venance, Laurent
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.12.2016; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378/1595/2167; 631/378/2591/2595; 631/378/2596/1308; 631/378/87; 9/74; Action Potentials; Amino acids; Animals; Astrocytes; Astrocytes - drug effects; Astrocytes - physiology; Ceftriaxone - pharmacology; Contingency; Corpus Striatum - cytology; Corpus Striatum - drug effects; Corpus Striatum - physiology; Emergence; Excitatory Amino Acid Transporter 2 - agonists; Excitatory Amino Acid Transporter 2 - antagonists & inhibitors; Excitatory Amino Acid Transporter 2 - physiology; gamma-Aminobutyric Acid - physiology; Hebbian plasticity; Humanities and Social Sciences; In Vitro Techniques; Investigations; Life Sciences; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Models, Neurological; multidisciplinary; Neostriatum; Neural plasticity; Neuronal Plasticity - physiology; Physiology; Plasticity; Rats; Receptors, N-Methyl-D-Aspartate - physiology; Science; Science (multidisciplinary); Sensory Gating; Synaptic plasticity; Variance analysis

Astrocytes, via excitatory amino-acid transporter type-2 (EAAT2), are the major sink for released glutamate and contribute to set the strength and timing of synaptic inputs. The conditions required for the emergence of Hebbian plasticity from distributed neural activity remain elusive. Here, we inve...