Correction of β-thalassemia mutant by base editor in human embryos - Liang, Puping; Ding, Chenhui; Sun, Hongwei; Xie, Xiaowei; Xu, Yanwen; Zhang, Xiya; Sun, Ying; Xiong, Yuanyan; Ma, Wenbin; Liu, Yongxiang; Wang, Yali; Fang, Jianpei; et al. (Protein & cell, 2017)
Keywords: APOBEC-1 Deaminase - genetics; APOBEC-1 Deaminase - metabolism; base editor; Base Sequence; beta-Globins - genetics; beta-Globins - metabolism; beta-Thalassemia - genetics; beta-Thalassemia - metabolism; beta-Thalassemia - pathology; beta-Thalassemia - therapy; Biochemistry; Biomedical and Life Sciences; Blastomeres; Blastomeres - cytology; Blastomeres - metabolism; Cell Biology; CRISPR-Cas Systems; Deamination; Developmental Biology; Embryo, Mammalian - metabolism; Embryo, Mammalian - pathology; Feasibility studies; Female; Fibroblasts; Fibroblasts - metabolism; Fibroblasts - pathology; Gene Editing - methods; Gene Expression; HBB gene; HBB −28 (A>G); HEK293 Cells; Heterozygote; Homozygote; human embryo; Human Genetics; Humans; Life Sciences; Mutation; Nuclear transfer; Oocytes; Point Mutation; Primary Cell Culture; Promoter Regions, Genetic; Protein Science; Sequence Analysis, DNA; Short; Short Article; Skin; Somatic cells; Stem Cells; Thalassemia; β-thalassemia; 28 (A>G); base editor; human embryo; β-thalassemia; HBB −28 (A>G)