Genomic diversity in autopsy samples reveals within-host dissemination of HIV-associated Mycobacterium tuberculosis

• Published in: Nature medicine Vol. 22; no. 12; pp. 1470 - 1474
• Main Authors: Lieberman, Tami D, Wilson, Douglas, Misra, Reshma, Xiong, Lealia L, Moodley, Prashini, Cohen, Ted, Kishony, Roy
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.12.2016; Nature Publishing Group
• Subjects: 631/181/2474; 631/326/107; 631/326/325/2482; 692/308/174; 692/699/255/1856; Adult; Aged; Autopsies; Autopsy; Bacteria; Bacteriological Techniques; Biodiversity; Biomedicine; Cancer Research; Coinfection - microbiology; DNA, Bacterial - genetics; Female; Genetic aspects; Genetic diversity; Genetic Variation; Genomics; HIV; HIV Infections - complications; Human immunodeficiency virus; Humans; Infectious Diseases; Lentivirus; letter; Liver - microbiology; Lung - microbiology; Lymph Nodes - microbiology; Male; Metabolic Diseases; Middle Aged; Molecular Medicine; Mycobacterium tuberculosis; Mycobacterium tuberculosis - genetics; Neurosciences; Outbreaks; Pathogens; Phylogeny; Polymorphism, Single Nucleotide; Retroviridae; South Africa; Spleen - microbiology; Tuberculosis; Tuberculosis - complications; Tuberculosis - microbiology; Tuberculosis, Hepatic - complications; Tuberculosis, Hepatic - microbiology; Tuberculosis, Lymph Node - complications; Tuberculosis, Lymph Node - microbiology; Tuberculosis, Pulmonary - complications; Tuberculosis, Pulmonary - microbiology; Tuberculosis, Splenic - complications; Tuberculosis, Splenic - microbiology; South Africa

Genomic analysis of Mycobacterium tuberculosis in postmortem biopsies provides a window into intrahost diversification of a disseminated pathogen. Mycobacterium tuberculosis remains a leading cause of death worldwide, especially among individuals infected with HIV 1 . Whereas phylogenetic analysis h...