Repeated vaccinations do not improve specific immune defenses against Hepatitis B in non-responder health care workers

• Published in: Vaccine Vol. 32; no. 51; pp. 6902 - 6910
• Main Authors: Zaffina, Salvatore, Marcellini, Valentina, Santoro, Anna Paola, Scarsella, Marco, Camisa, Vincenzo, Vinci, Maria Rosaria, Musolino, Anna Maria, Nicolosi, Luciana, Rosado, M. Manuela, Carsetti, Rita
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 05.12.2014; Elsevier; Elsevier Limited
• Subjects: Adult; Allergy and Immunology; Anti-HBsAg specific antibodies; antibodies; antibody formation; Antigens; Applied microbiology; B-lymphocytes; B-Lymphocytes - immunology; Biological and medical sciences; blood serum; Bone marrow; Enzyme-Linked Immunospot Assay; Female; Flow Cytometry; Fundamental and applied biological sciences. Psychology; Health care; health care workers; health hazards; Health Personnel; Hepatitis; hepatitis B; Hepatitis B - prevention & control; Hepatitis B Antibodies - blood; hepatitis B antigens; Hepatitis B vaccine; Hepatitis B Vaccines - administration & dosage; Hepatitis B virus; Human viral diseases; Humans; Immune system; Immunization; Immunization, Secondary - methods; Immunoglobulins; Immunologic Memory; Infectious diseases; Lymphocytes; Male; Medical sciences; Memory B cells; Microbiology; Middle Aged; Miscellaneous; Non-responders; secondary immunization; Serologic Tests; serology; Subpopulations; vaccination; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Viral diseases; Viral hepatitis; Virology; Young Adult; Hepatitis B vaccine; Memory B cells; Non-responders; Anti-HBsAg specific antibodies; Hepatitis B surface antigen; Antibody; Vaccination; Orthohepadnavirus; Hepatic disease; B-Lymphocyte; Vaccine; Infection; Virus; Viral hepatitis B; Hepadnaviridae; Viral disease; Digestive diseases; Hepatitis B virus

Hepatitis B is a major infectious occupational hazard for health care workers and can be prevented with a safe and effective vaccine. The serum titer of anti-HBsAg antibodies is the most commonly used correlate of protection and post-vaccination anti-HBsAg concentrations of ≥10mIU/ml are considered...