Plasticity of the Central Nervous System Involving Peripheral Nerve Transfer
Peripheral nerve injury can lead to partial or complete loss of limb function, and nerve transfer is an effective surgical salvage for patients with these injuries. The inability of deprived cortical regions representing damaged nerves to overcome corresponding maladaptive plasticity after the reinn...
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| Published in | Journal of neural transplantation & plasticity Vol. 2022; pp. 1 - 10 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
United States
Hindawi
18.03.2022
John Wiley & Sons, Inc Wiley |
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| Online Access | Get full text |
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| Abstract | Peripheral nerve injury can lead to partial or complete loss of limb function, and nerve transfer is an effective surgical salvage for patients with these injuries. The inability of deprived cortical regions representing damaged nerves to overcome corresponding maladaptive plasticity after the reinnervation of muscle fibers and sensory receptors is thought to be correlated with lasting and unfavorable functional recovery. However, the concept of central nervous system plasticity is rarely elucidated in classical textbooks involving peripheral nerve injury, let alone peripheral nerve transfer. This article is aimed at providing a comprehensive understanding of central nervous system plasticity involving peripheral nerve injury by reviewing studies mainly in human or nonhuman primate and by highlighting the functional and structural modifications in the central nervous system after peripheral nerve transfer. Hopefully, it will help surgeons perform successful nerve transfer under the guidance of modern concepts in neuroplasticity. |
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| AbstractList | Peripheral nerve injury can lead to partial or complete loss of limb function, and nerve transfer is an effective surgical salvage for patients with these injuries. The inability of deprived cortical regions representing damaged nerves to overcome corresponding maladaptive plasticity after the reinnervation of muscle fibers and sensory receptors is thought to be correlated with lasting and unfavorable functional recovery. However, the concept of central nervous system plasticity is rarely elucidated in classical textbooks involving peripheral nerve injury, let alone peripheral nerve transfer. This article is aimed at providing a comprehensive understanding of central nervous system plasticity involving peripheral nerve injury by reviewing studies mainly in human or nonhuman primate and by highlighting the functional and structural modifications in the central nervous system after peripheral nerve transfer. Hopefully, it will help surgeons perform successful nerve transfer under the guidance of modern concepts in neuroplasticity. Peripheral nerve injury can lead to partial or complete loss of limb function, and nerve transfer is an effective surgical salvage for patients with these injuries. The inability of deprived cortical regions representing damaged nerves to overcome corresponding maladaptive plasticity after the reinnervation of muscle fibers and sensory receptors is thought to be correlated with lasting and unfavorable functional recovery. However, the concept of central nervous system plasticity is rarely elucidated in classical textbooks involving peripheral nerve injury, let alone peripheral nerve transfer. This article is aimed at providing a comprehensive understanding of central nervous system plasticity involving peripheral nerve injury by reviewing studies mainly in human or nonhuman primate and by highlighting the functional and structural modifications in the central nervous system after peripheral nerve transfer. Hopefully, it will help surgeons perform successful nerve transfer under the guidance of modern concepts in neuroplasticity.Peripheral nerve injury can lead to partial or complete loss of limb function, and nerve transfer is an effective surgical salvage for patients with these injuries. The inability of deprived cortical regions representing damaged nerves to overcome corresponding maladaptive plasticity after the reinnervation of muscle fibers and sensory receptors is thought to be correlated with lasting and unfavorable functional recovery. However, the concept of central nervous system plasticity is rarely elucidated in classical textbooks involving peripheral nerve injury, let alone peripheral nerve transfer. This article is aimed at providing a comprehensive understanding of central nervous system plasticity involving peripheral nerve injury by reviewing studies mainly in human or nonhuman primate and by highlighting the functional and structural modifications in the central nervous system after peripheral nerve transfer. Hopefully, it will help surgeons perform successful nerve transfer under the guidance of modern concepts in neuroplasticity. |
| Audience | Academic |
| Author | Shen, Jun |
| AuthorAffiliation | Department of Orthopaedic Oncology, The Second Affiliated Hospital of Naval Medical University, Naval Medical University, No. 415 Fengyang Road, Huangpu District, Shanghai, China |
| AuthorAffiliation_xml | – name: Department of Orthopaedic Oncology, The Second Affiliated Hospital of Naval Medical University, Naval Medical University, No. 415 Fengyang Road, Huangpu District, Shanghai, China |
| Author_xml | – sequence: 1 givenname: Jun orcidid: 0000-0003-3545-059X surname: Shen fullname: Shen, Jun organization: Department of Orthopaedic OncologyThe Second Affiliated Hospital of Naval Medical UniversityNaval Medical UniversityNo. 415 Fengyang RoadHuangpu DistrictShanghaiChinasmmu.edu.cn |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35342394$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | Copyright © 2022 Jun Shen. COPYRIGHT 2022 John Wiley & Sons, Inc. Copyright © 2022 Jun Shen. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2022 Jun Shen. 2022 |
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| Snippet | Peripheral nerve injury can lead to partial or complete loss of limb function, and nerve transfer is an effective surgical salvage for patients with these... |
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| SubjectTerms | Animals Central Nervous System Humans Nerve Regeneration - physiology Nerve Transfer Nervous system Neuronal Plasticity - physiology Neuroplasticity Paralysis Peripheral Nerve Injuries Peripheral Nerves Review Skin Spinal cord Tomography |
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| Title | Plasticity of the Central Nervous System Involving Peripheral Nerve Transfer |
| URI | https://dx.doi.org/10.1155/2022/5345269 https://www.ncbi.nlm.nih.gov/pubmed/35342394 https://www.proquest.com/docview/2643822594 https://www.proquest.com/docview/2644361505 https://pubmed.ncbi.nlm.nih.gov/PMC8956439 https://doaj.org/article/a96a0561ebfe4799907c4e1e2fecd972 |
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