Mechanisms of restriction of viral neuroinvasion at the blood–brain barrier

• Published in: Current opinion in immunology Vol. 38; pp. 18 - 23
• Main Authors: Miner, Jonathan J, Diamond, Michael S
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2016
• Subjects: Allergy and Immunology; Animals; Astrocytes - immunology; Astrocytes - pathology; Astrocytes - virology; Blood-Brain Barrier - immunology; Blood-Brain Barrier - pathology; Blood-Brain Barrier - virology; Brain - blood supply; Brain - immunology; Brain - pathology; Brain - virology; Cell Movement; Cytokines - genetics; Cytokines - immunology; Endothelial Cells - immunology; Endothelial Cells - pathology; Endothelial Cells - virology; Gene Expression Regulation; Host-Pathogen Interactions; Humans; Leukocytes - immunology; Leukocytes - pathology; Leukocytes - virology; Microglia - immunology; Microglia - pathology; Microglia - virology; Neurons - immunology; Neurons - pathology; Neurons - virology; Pericytes - immunology; Pericytes - pathology; Pericytes - virology; Signal Transduction; Virus Diseases - immunology; Virus Diseases - pathology; Virus Diseases - virology; Viruses - immunology; Viruses - pathogenicity

•Neurotropic viruses invade the CNS via several routes including direct transit across the blood–brain barrier (BBB).•Pro-inflammatory cytokines promote BBB breakdown during viral infection.•IFN-β, IFN-λ, and TAM receptor signaling enhance BBB integrity.•Gastrointestinal microbiota modulate BBB func...