The Identification of Vesicular Glutamate Transporter 3 Suggests Novel Modes of Signaling by Glutamate

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 99; no. 22; pp. 14488 - 14493
• Main Authors: Fremeau, Robert T., Burman, Jonathon, Qureshi, Tayyaba, Tran, Cindy H., Proctor, John, Johnson, Juliette, Zhang, Hui, Sulzer, David, Copenhagen, David R., Storm-Mathisen, Jon, Reimer, Richard J., Chaudhry, Farrukh A., Edwards, Robert H.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 29.10.2002; National Acad Sciences
• Subjects: Amacrine cells; Amino Acid Transport Systems, Acidic - genetics; Amino Acid Transport Systems, Acidic - metabolism; Animals; Biological Sciences; Blood vessels; Brain - metabolism; Brain - pathology; Cell Membrane - metabolism; Cell nucleus; Dendrites; Dendrites - metabolism; Glutamic Acid - metabolism; Hippocampus; Humans; Hydrogen-Ion Concentration; Kidney - metabolism; Kidney - pathology; Liver - metabolism; Liver - pathology; Male; Neuroglia; Neurology; Neurons; PC12 Cells; Purkinje cells; Pyramidal cells; Rats; Signal Transduction; Synapses; Tissue Distribution; Vesicular Glutamate Transport Proteins

Quantal release of the principal excitatory neurotransmitter glutamate requires a mechanism for its transport into secretory vesicles. Within the brain, the complementary expression of vesicular glutamate transporters (VGLUTs) 1 and 2 accounts for the release of glutamate by all known excitatory neu...