The Identification of Vesicular Glutamate Transporter 3 Suggests Novel Modes of Signaling by Glutamate
Quantal release of the principal excitatory neurotransmitter glutamate requires a mechanism for its transport into secretory vesicles. Within the brain, the complementary expression of vesicular glutamate transporters (VGLUTs) 1 and 2 accounts for the release of glutamate by all known excitatory neu...
Saved in:
| Published in | Proceedings of the National Academy of Sciences - PNAS Vol. 99; no. 22; pp. 14488 - 14493 |
|---|---|
| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
National Academy of Sciences
29.10.2002
National Acad Sciences |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Quantal release of the principal excitatory neurotransmitter glutamate requires a mechanism for its transport into secretory vesicles. Within the brain, the complementary expression of vesicular glutamate transporters (VGLUTs) 1 and 2 accounts for the release of glutamate by all known excitatory neurons. We now report the identification of VGLUT3 and its expression by many cells generally considered to release a classical transmitter with properties very different from glutamate. Remarkably, subpopulations of inhibitory neurons as well as cholinergic interneurons, monoamine neurons, and glia express VGLUT3. The dendritic expression of VGLUT3 by particular neurons also indicates the potential for retrograde synaptic signaling. The distribution and subcellular location of VGLUT3 thus suggest novel modes of signaling by glutamate. |
|---|---|
| AbstractList | Quantal release of the principal excitatory neurotransmitter glutamate requires a mechanism for its transport into secretory vesicles. Within the brain, the complementary expression of vesicular glutamate transporters (VGLUTs) 1 and 2 accounts for the release of glutamate by all known excitatory neurons. We now report the identification of VGLUT3 and its expression by many cells generally considered to release a classical transmitter with properties very different from glutamate. Remarkably, subpopulations of inhibitory neurons as well as cholinergic interneurons, monoamine neurons, and glia express VGLUT3. The dendritic expression of VGLUT3 by particular neurons also indicates the potential for retrograde synaptic signaling. The distribution and subcellular location of VGLUT3 thus suggest novel modes of signaling by glutamate. |
| Author | Zhang, Hui Tran, Cindy H. Reimer, Richard J. Proctor, John Fremeau, Robert T. Burman, Jonathon Sulzer, David Copenhagen, David R. Johnson, Juliette Qureshi, Tayyaba Edwards, Robert H. Chaudhry, Farrukh A. Storm-Mathisen, Jon |
| AuthorAffiliation | Departments of Neurology and Physiology and § Ophthalmology and Physiology, Graduate Programs in Neuroscience and Cell Biology, University of California School of Medicine, San Francisco, CA 94143; ‡ Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, N-0317 Oslo, Norway; and ¶ Departments of Neurology and Psychiatry, Columbia University, Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032 |
| AuthorAffiliation_xml | – name: Departments of Neurology and Physiology and § Ophthalmology and Physiology, Graduate Programs in Neuroscience and Cell Biology, University of California School of Medicine, San Francisco, CA 94143; ‡ Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, N-0317 Oslo, Norway; and ¶ Departments of Neurology and Psychiatry, Columbia University, Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032 |
| Author_xml | – sequence: 1 givenname: Robert T. surname: Fremeau fullname: Fremeau, Robert T. – sequence: 2 givenname: Jonathon surname: Burman fullname: Burman, Jonathon – sequence: 3 givenname: Tayyaba surname: Qureshi fullname: Qureshi, Tayyaba – sequence: 4 givenname: Cindy H. surname: Tran fullname: Tran, Cindy H. – sequence: 5 givenname: John surname: Proctor fullname: Proctor, John – sequence: 6 givenname: Juliette surname: Johnson fullname: Johnson, Juliette – sequence: 7 givenname: Hui surname: Zhang fullname: Zhang, Hui – sequence: 8 givenname: David surname: Sulzer fullname: Sulzer, David – sequence: 9 givenname: David R. surname: Copenhagen fullname: Copenhagen, David R. – sequence: 10 givenname: Jon surname: Storm-Mathisen fullname: Storm-Mathisen, Jon – sequence: 11 givenname: Richard J. surname: Reimer fullname: Reimer, Richard J. – sequence: 12 givenname: Farrukh A. surname: Chaudhry fullname: Chaudhry, Farrukh A. – sequence: 13 givenname: Robert H. surname: Edwards fullname: Edwards, Robert H. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12388773$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kT1vFDEURS0URDaBlgqBRYFodvHXjMcFBYogRApQZEVreTz2xCuvvdieiPx7PNplAxRUr3jnPN2newZOQgwGgOcYrTDi9N0uqLwihDSs5UI8AguMBF62TKATsECI8GXHCDsFZzlvEEKi6dATcIoJ7TrO6QLY9a2BV4MJxVmnVXExwGjhd5OdnrxK8NJPRW1VMXCdVMi7mIpJkMKbaRxNLhl-jXfGwy9xMHk2b9wYlHdhhP39g_wUPLbKZ_PsMM_B-tPH9cXn5fW3y6uLD9dL3WJSlhxj1TQM69a2ttdcq5ZRQUXbCN5opYUZUE-UsAOlRA_MEk6GXuNOI2a1oOfg_f7sbuq3ZtD1raS83CW3VeleRuXk35vgbuUY7ySmXGBU_TcHP8UfU31Pbl3WxnsVTJyyxF2LmpZ3FXz9D7iJU6qPZ0kQJqLBgldotYd0ijknY49BMJJze3JuTx7bq8LLP-M_4Ie6KvDqAMzi77UQ9YbEjHVzsLf_J6SdvC_mZ6noiz26ySWmI0trsFoG_QW5KLs2 |
| CitedBy_id | crossref_primary_10_1016_j_neuroscience_2014_04_010 crossref_primary_10_1111_j_1460_9568_2011_07594_x crossref_primary_10_1002_glia_22348 crossref_primary_10_3748_wjg_v21_i10_2959 crossref_primary_10_1002_cne_23189 crossref_primary_10_1177_1073858405275827 crossref_primary_10_1371_journal_pone_0097240 crossref_primary_10_1111_j_0953_816X_2003_03091_x crossref_primary_10_1002_glia_22341 crossref_primary_10_1093_cercor_bhr107 crossref_primary_10_1523_JNEUROSCI_5196_09_2010 crossref_primary_10_1016_j_mcn_2010_06_016 crossref_primary_10_1007_s00429_017_1462_7 crossref_primary_10_1111_j_1365_2826_2006_01410_x crossref_primary_10_1152_ajpheart_00202_2006 crossref_primary_10_1523_JNEUROSCI_3667_12_2013 crossref_primary_10_1111_j_1460_9568_2007_05400_x crossref_primary_10_1111_j_1471_4159_2006_03821_x crossref_primary_10_1523_JNEUROSCI_1705_12_2012 crossref_primary_10_1007_s11064_007_9546_z crossref_primary_10_1038_nn2052 crossref_primary_10_1016_j_brainres_2009_11_014 crossref_primary_10_1007_s00429_013_0609_4 crossref_primary_10_1523_JNEUROSCI_3770_03_2004 crossref_primary_10_3390_cells13131130 crossref_primary_10_1016_j_neuroscience_2008_07_032 crossref_primary_10_1016_j_resp_2008_07_024 crossref_primary_10_1126_science_1100475 crossref_primary_10_1016_j_neulet_2004_02_039 crossref_primary_10_1111_j_1460_9568_2009_07071_x crossref_primary_10_14814_phy2_13158 crossref_primary_10_1017_S0952523816000146 crossref_primary_10_1016_S0306_4522_03_00568_2 crossref_primary_10_1038_s41583_019_0151_3 crossref_primary_10_1073_pnas_0401764101 crossref_primary_10_1002_cne_23043 crossref_primary_10_1002_cne_23165 crossref_primary_10_1002_cne_20928 crossref_primary_10_1101_lm_037317_114 crossref_primary_10_1016_j_pharmthera_2005_11_006 crossref_primary_10_1016_j_bcp_2021_114786 crossref_primary_10_1007_s10571_017_0528_7 crossref_primary_10_1523_JNEUROSCI_3003_04_2005 crossref_primary_10_1021_acschemneuro_8b00419 crossref_primary_10_1016_j_pneurobio_2018_09_006 crossref_primary_10_1016_j_celrep_2018_05_063 crossref_primary_10_1016_j_neuint_2003_08_001 crossref_primary_10_1016_j_neulet_2016_03_039 crossref_primary_10_3389_fncel_2021_789903 crossref_primary_10_1093_jb_mvh018 crossref_primary_10_3748_wjg_v11_i12_1731 crossref_primary_10_1016_j_neuroscience_2007_12_029 crossref_primary_10_1371_journal_pone_0203852 crossref_primary_10_1515_REVNEURO_2008_19_4_5_227 crossref_primary_10_1002_cne_21081 crossref_primary_10_1002_glia_20367 crossref_primary_10_1016_j_neuint_2005_12_027 crossref_primary_10_1073_pnas_1711622114 crossref_primary_10_1016_j_jchemneu_2009_02_002 crossref_primary_10_1016_j_heares_2018_04_006 crossref_primary_10_1016_j_schres_2010_05_015 crossref_primary_10_1016_j_brainres_2007_06_042 crossref_primary_10_1046_j_1432_1033_2003_03907_x crossref_primary_10_1146_annurev_pharmtox_011008_145602 crossref_primary_10_1016_j_baga_2012_01_002 crossref_primary_10_7554_eLife_51996 crossref_primary_10_1016_j_brainresbull_2010_06_010 crossref_primary_10_1111_j_1399_5618_2009_00752_x crossref_primary_10_1002_dneu_20889 crossref_primary_10_1016_j_neuroscience_2006_09_024 crossref_primary_10_1002_cne_25452 crossref_primary_10_1007_s11064_023_03921_z crossref_primary_10_1016_j_neuroscience_2005_08_048 crossref_primary_10_1177_002215540305101014 crossref_primary_10_1254_jphs_94_215 crossref_primary_10_1016_j_tins_2003_11_005 crossref_primary_10_1016_j_pneurobio_2012_04_004 crossref_primary_10_1016_j_neuron_2016_02_023 crossref_primary_10_1146_annurev_neuro_26_041002_131412 crossref_primary_10_1016_j_brainresbull_2008_08_015 crossref_primary_10_1124_mol_120_000089 crossref_primary_10_1523_JNEUROSCI_23_20_07659_2003 crossref_primary_10_1016_j_neuroscience_2009_02_048 crossref_primary_10_1016_j_jchemneu_2012_02_001 crossref_primary_10_1111_j_1471_4159_2006_04359_x crossref_primary_10_1016_j_neuron_2016_03_026 crossref_primary_10_1152_jn_00130_2009 crossref_primary_10_1097_01_wnr_0000203351_06881_54 crossref_primary_10_1016_j_ajhg_2008_07_008 crossref_primary_10_1095_biolreprod_103_019745 crossref_primary_10_1007_s00441_014_1921_x crossref_primary_10_1016_j_neuint_2005_12_013 crossref_primary_10_1016_j_exer_2015_05_005 crossref_primary_10_1016_j_brainres_2008_03_038 crossref_primary_10_3389_fnmol_2019_00211 crossref_primary_10_1016_j_pneurobio_2004_05_006 crossref_primary_10_1016_j_neuroscience_2015_12_009 crossref_primary_10_1038_s41467_024_46996_0 crossref_primary_10_1007_s00213_006_0527_8 crossref_primary_10_1016_j_brainresrev_2009_11_008 crossref_primary_10_1016_j_schres_2009_08_003 crossref_primary_10_1002_cne_24439 crossref_primary_10_1093_cercor_bhn151 crossref_primary_10_1007_s00429_012_0395_4 crossref_primary_10_1016_j_bbamem_2020_183175 crossref_primary_10_1007_s00429_011_0339_4 crossref_primary_10_1016_j_neuroscience_2018_09_008 crossref_primary_10_1002_glia_21085 crossref_primary_10_1016_S1016_8478_23_17549_2 crossref_primary_10_1152_ajpregu_00127_2016 crossref_primary_10_1016_j_yhbeh_2017_02_012 crossref_primary_10_1002_wdev_301 crossref_primary_10_1016_j_neubiorev_2016_05_015 crossref_primary_10_1002_cne_21265 crossref_primary_10_1038_nrn2803 crossref_primary_10_1371_journal_pbio_1001194 crossref_primary_10_1002_cne_23680 crossref_primary_10_1002_neu_20146 crossref_primary_10_1016_j_jchemneu_2013_02_007 crossref_primary_10_1002_cne_22597 crossref_primary_10_1038_ncomms4791 crossref_primary_10_1097_WNR_0000000000001687 crossref_primary_10_3389_fnana_2022_937504 crossref_primary_10_1002_cne_22237 crossref_primary_10_1016_j_brainres_2012_01_012 crossref_primary_10_1111_j_1471_4159_2006_03935_x crossref_primary_10_1016_j_pathophys_2009_12_001 crossref_primary_10_1016_j_mcpro_2023_100704 crossref_primary_10_1016_j_neuint_2007_06_005 crossref_primary_10_1111_j_1471_4159_2012_07664_x crossref_primary_10_1002_cne_21054 crossref_primary_10_1016_j_jchemneu_2009_05_005 crossref_primary_10_1091_mbc_e04_07_0559 crossref_primary_10_1002_cne_23331 crossref_primary_10_1152_ajpcell_00015_2012 crossref_primary_10_1016_S0301_0082_03_00087_X crossref_primary_10_1016_j_brainresrev_2004_04_004 crossref_primary_10_1046_j_1460_9568_2003_02697_x crossref_primary_10_1111_j_1460_9568_2008_06136_x crossref_primary_10_1016_j_nbd_2008_05_019 crossref_primary_10_1002_cne_21047 crossref_primary_10_1002_cne_20199 crossref_primary_10_1016_j_neuropharm_2015_05_011 crossref_primary_10_1523_JNEUROSCI_4074_09_2010 crossref_primary_10_1042_BJ20101912 crossref_primary_10_1080_10253890_2017_1423053 crossref_primary_10_1007_s10571_017_0559_0 crossref_primary_10_1016_j_brainres_2010_08_102 crossref_primary_10_1016_j_neuroscience_2015_10_052 crossref_primary_10_1152_ajpcell_00444_2004 crossref_primary_10_1016_j_neuroscience_2008_03_074 crossref_primary_10_1016_j_neuroscience_2010_12_059 crossref_primary_10_1002_cne_20267 crossref_primary_10_1016_j_neuroscience_2008_03_078 crossref_primary_10_1038_s41380_021_01187_x crossref_primary_10_1021_acschemneuro_0c00272 crossref_primary_10_1016_j_jtherbio_2004_08_001 crossref_primary_10_1016_j_neuron_2007_11_032 crossref_primary_10_1016_j_neuroscience_2010_11_013 crossref_primary_10_3389_fncel_2022_1037641 crossref_primary_10_1038_nrn2969 crossref_primary_10_1111_j_1460_9568_2010_07228_x crossref_primary_10_1111_j_1460_9568_2004_03628_x crossref_primary_10_1002_cne_24407 crossref_primary_10_1002_cne_21109 crossref_primary_10_1021_bi200567k crossref_primary_10_1002_cne_21105 crossref_primary_10_3389_fphys_2020_00643 crossref_primary_10_1002_cne_21587 crossref_primary_10_1523_JNEUROSCI_0549_05_2005 crossref_primary_10_3389_fnana_2022_1000085 crossref_primary_10_1002_cne_20012 crossref_primary_10_1016_S0165_3806_02_00617_X crossref_primary_10_1254_fpj_122_253 crossref_primary_10_1002_cne_20250 crossref_primary_10_1016_j_jchemneu_2005_12_002 crossref_primary_10_1016_j_neuroscience_2007_09_035 crossref_primary_10_1152_ajpregu_00300_2014 crossref_primary_10_1074_jbc_M312845200 crossref_primary_10_1002_ar_a_20184 crossref_primary_10_1186_1756_6606_6_32 crossref_primary_10_1016_j_brainres_2006_01_111 crossref_primary_10_1371_journal_pcbi_1002976 crossref_primary_10_1113_expphysiol_2012_069922 crossref_primary_10_1016_j_exer_2009_03_024 crossref_primary_10_1007_s10620_011_1970_x crossref_primary_10_1042_BSR20220497 crossref_primary_10_4199_C00135ED1V01Y201507NGL008 crossref_primary_10_1016_j_neuint_2010_02_007 crossref_primary_10_1177_1073858414523320 crossref_primary_10_1016_j_neuint_2016_04_016 crossref_primary_10_1016_j_neulet_2014_10_053 crossref_primary_10_1152_physiol_00033_2012 crossref_primary_10_1002_cne_22200 crossref_primary_10_1002_cne_23533 crossref_primary_10_1371_journal_pone_0109824 crossref_primary_10_1523_JNEUROSCI_4884_03_2004 crossref_primary_10_1093_cercor_bhp133 crossref_primary_10_1111_j_1460_9568_2006_05263_x crossref_primary_10_1016_j_neuroscience_2011_12_006 crossref_primary_10_1002_cne_20399 crossref_primary_10_1111_j_1460_9568_2011_07882_x crossref_primary_10_1186_1471_2202_7_54 crossref_primary_10_1016_j_celrep_2020_108040 crossref_primary_10_1016_j_neuroscience_2007_02_068 crossref_primary_10_1016_j_bbr_2013_01_042 crossref_primary_10_3390_ijms21249607 crossref_primary_10_1016_j_nlm_2011_01_010 crossref_primary_10_1210_en_2005_1229 crossref_primary_10_1002_cne_21678 crossref_primary_10_1517_13543784_14_12_1487 crossref_primary_10_1016_j_neulet_2009_08_042 crossref_primary_10_1016_j_neuropharm_2011_04_008 crossref_primary_10_1124_mol_108_050005 crossref_primary_10_3389_fnana_2016_00039 crossref_primary_10_1016_j_neuropharm_2021_108602 crossref_primary_10_1254_jphs_11R03CR crossref_primary_10_3389_fncel_2017_00140 crossref_primary_10_1016_j_jchemneu_2011_04_004 crossref_primary_10_1111_ejn_15400 crossref_primary_10_1002_ar_21465 crossref_primary_10_1016_j_ydbio_2021_04_001 crossref_primary_10_1016_j_conb_2011_04_004 crossref_primary_10_1073_pnas_0404864101 crossref_primary_10_1146_annurev_pharmtox_46_120604_141146 crossref_primary_10_1016_j_jchemneu_2015_12_016 crossref_primary_10_1196_annals_1300_046 crossref_primary_10_1248_bpb_29_547 crossref_primary_10_1002_cne_22634 crossref_primary_10_1007_s00726_011_0866_6 crossref_primary_10_1186_1471_2164_11_17 crossref_primary_10_1523_ENEURO_0007_19_2019 crossref_primary_10_1002_cne_21576 crossref_primary_10_1073_pnas_2118430119 crossref_primary_10_1046_j_1460_9568_2003_02840_x crossref_primary_10_1002_syn_20581 crossref_primary_10_1523_JNEUROSCI_4057_12_2012 crossref_primary_10_1152_physrev_00042_2016 crossref_primary_10_1016_j_neures_2004_09_007 crossref_primary_10_1113_JP282181 crossref_primary_10_1111_j_1460_9568_2005_04240_x crossref_primary_10_3389_fncir_2018_00113 crossref_primary_10_1111_j_1460_9568_2004_03544_x crossref_primary_10_1002_cne_22521 crossref_primary_10_1016_j_neuint_2003_12_011 crossref_primary_10_1002_cne_21208 crossref_primary_10_1016_j_neuroscience_2008_03_029 crossref_primary_10_3109_03009734_2015_1032454 crossref_primary_10_1097_00001756_200403010_00010 crossref_primary_10_1523_JNEUROSCI_0012_07_2007 crossref_primary_10_1002_cne_20354 crossref_primary_10_1113_JP272036 crossref_primary_10_1016_j_neuroscience_2003_10_039 crossref_primary_10_1016_j_neuropharm_2005_07_023 crossref_primary_10_1111_j_1365_2826_2008_01719_x crossref_primary_10_1016_j_neures_2006_05_008 crossref_primary_10_1016_j_brainres_2011_03_004 crossref_primary_10_1016_j_ejphar_2019_172474 crossref_primary_10_1002_cne_22730 crossref_primary_10_1111_j_1528_1167_2010_02583_x crossref_primary_10_1046_j_1460_9568_2003_02898_x crossref_primary_10_1002_cne_22734 crossref_primary_10_1111_j_1471_4159_2007_04758_x crossref_primary_10_1038_nn_2478 crossref_primary_10_1002_cne_10860 crossref_primary_10_1111_j_1471_4159_2007_05065_x crossref_primary_10_1021_cr068081q crossref_primary_10_1371_journal_pone_0019155 crossref_primary_10_1111_jnc_14003 crossref_primary_10_1046_j_1471_4159_2003_02277_x crossref_primary_10_3390_biom11091367 crossref_primary_10_1210_en_2004_0856 crossref_primary_10_1002_cne_21868 crossref_primary_10_1002_jnr_20500 crossref_primary_10_1007_s11427_021_2047_8 crossref_primary_10_1016_j_heares_2014_02_004 crossref_primary_10_1212_01_WNL_0000095205_33940_99 crossref_primary_10_1111_j_1460_9568_2008_06029_x crossref_primary_10_1073_pnas_0910986107 crossref_primary_10_1016_j_physbeh_2019_112688 crossref_primary_10_1073_pnas_1919250117 crossref_primary_10_1016_j_ijdevneu_2006_12_005 crossref_primary_10_1016_j_jchemneu_2009_06_001 crossref_primary_10_1016_j_neulet_2008_01_082 crossref_primary_10_1016_j_neuron_2014_10_021 crossref_primary_10_1111_j_1530_0277_2006_00176_x crossref_primary_10_1007_s11064_012_0766_5 crossref_primary_10_1016_j_euroneuro_2015_11_005 crossref_primary_10_1007_s00221_013_3679_x crossref_primary_10_1016_j_neuroscience_2003_09_033 crossref_primary_10_1002_cne_21414 crossref_primary_10_1016_j_neuroscience_2010_06_003 crossref_primary_10_1002_cne_20444 crossref_primary_10_1111_j_1460_9568_2008_06576_x crossref_primary_10_1016_j_brainresbull_2017_01_015 crossref_primary_10_1523_JNEUROSCI_2124_15_2015 crossref_primary_10_1016_j_neulet_2005_10_033 crossref_primary_10_1016_j_neuroscience_2007_02_016 crossref_primary_10_1523_JNEUROSCI_3001_04_2004 crossref_primary_10_7554_eLife_55523 crossref_primary_10_1093_cercor_bhz204 crossref_primary_10_1523_JNEUROSCI_0557_05_2005 crossref_primary_10_1016_j_neuroscience_2015_02_033 crossref_primary_10_1002_cne_23811 crossref_primary_10_1111_ejn_12199 crossref_primary_10_1016_j_brainres_2003_10_032 crossref_primary_10_1038_nn_2248 crossref_primary_10_1523_JNEUROSCI_1498_13_2014 crossref_primary_10_4062_biomolther_2012_20_1_001 crossref_primary_10_1002_cne_20555 crossref_primary_10_1016_j_ijdevneu_2005_11_016 crossref_primary_10_1155_2013_829753 crossref_primary_10_1002_cne_10755 crossref_primary_10_1126_stke_2332004re8 crossref_primary_10_1016_j_neuint_2015_04_001 crossref_primary_10_1016_j_neuron_2007_09_010 crossref_primary_10_1016_j_ydbio_2013_09_025 crossref_primary_10_1016_j_neuroscience_2012_11_046 crossref_primary_10_1111_j_1460_9568_2005_03991_x crossref_primary_10_3389_fnana_2014_00021 crossref_primary_10_1002_hipo_20999 crossref_primary_10_1002_cne_20987 crossref_primary_10_1002_cne_20743 crossref_primary_10_1002_cne_20742 crossref_primary_10_3390_nu14112184 crossref_primary_10_1016_j_brainres_2007_08_014 crossref_primary_10_1016_j_neuroscience_2005_03_038 crossref_primary_10_1111_j_1460_9568_2006_04601_x crossref_primary_10_1038_nn1246 crossref_primary_10_1016_j_jchemneu_2005_01_002 crossref_primary_10_1016_j_phrs_2020_105103 crossref_primary_10_1016_j_neuroscience_2013_12_012 crossref_primary_10_1021_acschemneuro_3c00758 crossref_primary_10_1186_s12881_016_0269_3 crossref_primary_10_1016_j_jchemneu_2014_08_002 crossref_primary_10_1002_jnr_24587 crossref_primary_10_3389_fncir_2014_00140 crossref_primary_10_1007_s11064_016_2037_3 crossref_primary_10_1016_j_tips_2003_08_002 crossref_primary_10_1016_j_neures_2006_04_016 crossref_primary_10_1111_j_1471_4159_2007_04518_x crossref_primary_10_15252_embj_201592705 crossref_primary_10_1523_JNEUROSCI_0014_23_2023 crossref_primary_10_1016_S2214_3106_15_30002_9 crossref_primary_10_1016_j_neuropharm_2011_09_010 crossref_primary_10_1016_j_jchemneu_2008_06_003 crossref_primary_10_1016_j_nbd_2004_12_020 crossref_primary_10_1016_j_neuroscience_2016_09_013 crossref_primary_10_1016_j_neuint_2012_03_018 crossref_primary_10_1007_s11064_015_1622_1 crossref_primary_10_1007_s12035_012_8293_6 crossref_primary_10_1016_j_ejphar_2022_175298 crossref_primary_10_1002_bies_201600240 crossref_primary_10_1016_j_neuroscience_2013_05_044 crossref_primary_10_1002_cne_10962 crossref_primary_10_1523_JNEUROSCI_0282_16_2017 crossref_primary_10_1523_JNEUROSCI_4681_14_2015 crossref_primary_10_1371_journal_pone_0087709 crossref_primary_10_1002_cne_10838 crossref_primary_10_3389_fnana_2015_00023 crossref_primary_10_1016_j_neuron_2007_09_001 crossref_primary_10_1021_acs_biochem_1c00375 crossref_primary_10_1016_j_tips_2021_03_003 crossref_primary_10_1126_science_1097468 crossref_primary_10_1523_ENEURO_0332_23_2024 crossref_primary_10_4036_iis_2015_B_10 crossref_primary_10_1002_cne_25085 crossref_primary_10_1038_ncomms6390 crossref_primary_10_1371_journal_pone_0022960 crossref_primary_10_3390_ijms23020790 crossref_primary_10_1002_cne_20705 crossref_primary_10_1111_j_1749_6632_2010_05535_x crossref_primary_10_1002_cne_20942 crossref_primary_10_3389_fnsyn_2015_00016 crossref_primary_10_1111_j_1471_4159_2005_03636_x crossref_primary_10_1007_s00441_007_0392_8 crossref_primary_10_1002_cne_24088 crossref_primary_10_1016_j_jchemneu_2006_04_004 crossref_primary_10_1017_S0952523811000290 crossref_primary_10_1016_j_brainres_2013_09_019 crossref_primary_10_1111_nyas_12057 crossref_primary_10_1007_s10162_010_0224_5 crossref_primary_10_1016_j_brainres_2005_06_051 crossref_primary_10_1007_s00418_005_0083_z crossref_primary_10_1113_jphysiol_2011_216028 crossref_primary_10_1523_JNEUROSCI_4317_03_2004 crossref_primary_10_1002_cne_24092 crossref_primary_10_1016_j_brainres_2004_03_047 crossref_primary_10_1016_j_bbamcr_2010_11_006 crossref_primary_10_1016_j_neuint_2009_12_007 crossref_primary_10_1016_j_bbamem_2017_02_002 crossref_primary_10_1007_s00441_004_1054_8 crossref_primary_10_1002_hipo_22521 crossref_primary_10_3389_fnsyn_2016_00004 crossref_primary_10_3389_fnsyn_2016_00002 crossref_primary_10_1194_jlr_M700021_JLR200 crossref_primary_10_1007_s00429_016_1217_x crossref_primary_10_1046_j_0022_7722_2003_00059_x crossref_primary_10_1038_nn0504_419 crossref_primary_10_1007_s12035_020_01912_7 crossref_primary_10_1016_j_brainres_2005_04_018 crossref_primary_10_1007_s11064_012_0773_6 crossref_primary_10_1016_j_neuroscience_2006_10_053 crossref_primary_10_1111_j_1600_0854_2008_00771_x crossref_primary_10_1002_syn_10249 crossref_primary_10_1113_jphysiol_2012_230722 crossref_primary_10_1152_physrev_00024_2014 crossref_primary_10_1016_j_neuroscience_2015_09_041 crossref_primary_10_1111_j_1471_4159_2009_06251_x crossref_primary_10_1016_j_neuropharm_2009_08_022 crossref_primary_10_1110_ps_072944707 crossref_primary_10_1111_j_1471_4159_2006_04049_x crossref_primary_10_1002_glia_20849 crossref_primary_10_1189_jlb_0306153 crossref_primary_10_1098_rstb_2011_0378 crossref_primary_10_1074_jbc_M607670200 crossref_primary_10_1016_j_neuroscience_2003_08_065 |
| Cites_doi | 10.1074/jbc.M104578200 10.1016/S0896-6273(01)00344-0 10.1093/embo-reports/kvf159 10.1002/cne.903510305 10.1126/science.289.5481.957 10.1523/JNEUROSCI.18-23-09733.1998 10.1074/jbc.271.20.11726 10.1007/s004290050051 10.1002/cne.10129 10.1016/S0021-9258(18)83243-4 10.1016/S0092-8674(00)81674-8 10.1002/cne.903330309 10.1146/annurev.neuro.23.1.185 10.1126/science.1067020 10.1016/0197-0186(87)90176-8 10.1042/bj2670281 10.1038/35025070 10.1016/S0021-9258(19)37605-7 10.1002/jnr.10041 10.1016/0896-6273(95)90158-2 10.1523/JNEUROSCI.22-01-00142.2002 10.1016/0896-6273(94)90283-6 10.1074/jbc.271.29.17132 10.1038/360467a0 10.1523/JNEUROSCI.18-11-04022.1998 10.1523/JNEUROSCI.21-22-j0002.2001 10.1083/jcb.110.5.1693 10.1038/22768 10.1016/0896-6273(94)90038-8 10.1002/cne.903090308 10.1523/JNEUROSCI.15-12-08362.1995 10.1038/34651 10.1523/JNEUROSCI.22-13-05442.2002 10.1523/JNEUROSCI.12-04-01394.1992 10.1111/j.1469-7793.2000.00489.x 10.1523/JNEUROSCI.18-12-04588.1998 10.1016/0166-2236(95)98374-8 10.1016/S0896-6273(00)81013-2 10.1002/cne.903260210 10.1523/JNEUROSCI.21-22-j0001.2001 10.1523/JNEUROSCI.20-02-00666.2000 10.1093/jn/131.9.2491S 10.1073/pnas.101126398 |
| ContentType | Journal Article |
| Copyright | Copyright 1993-2002 National Academy of Sciences of the United States of America Copyright National Academy of Sciences Oct 29, 2002 Copyright © 2002, The National Academy of Sciences 2002 |
| Copyright_xml | – notice: Copyright 1993-2002 National Academy of Sciences of the United States of America – notice: Copyright National Academy of Sciences Oct 29, 2002 – notice: Copyright © 2002, The National Academy of Sciences 2002 |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QG 7QL 7QP 7QR 7SN 7SS 7T5 7TK 7TM 7TO 7U9 8FD C1K FR3 H94 M7N P64 RC3 5PM |
| DOI | 10.1073/pnas.222546799 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database AIDS and Cancer Research Abstracts Algology Mycology and Protozoology Abstracts (Microbiology C) Biotechnology and BioEngineering Abstracts Genetics Abstracts PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Virology and AIDS Abstracts Oncogenes and Growth Factors Abstracts Technology Research Database Nucleic Acids Abstracts Ecology Abstracts Neurosciences Abstracts Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management Entomology Abstracts Genetics Abstracts Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts Chemoreception Abstracts Immunology Abstracts Engineering Research Database Calcium & Calcified Tissue Abstracts |
| DatabaseTitleList | Virology and AIDS Abstracts CrossRef Neurosciences Abstracts MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) |
| EISSN | 1091-6490 |
| EndPage | 14493 |
| ExternalDocumentID | 239988061 10_1073_pnas_222546799 12388773 99_22_14488 3073612 |
| Genre | Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S Journal Article Feature |
| GroupedDBID | --- -DZ -~X .55 .GJ 0R~ 123 29P 2AX 2FS 2WC 3O- 4.4 53G 5RE 5VS 85S AACGO AAFWJ AANCE AAYJJ ABBHK ABOCM ABPLY ABPPZ ABTLG ABXSQ ABZEH ACGOD ACIWK ACNCT ACPRK ADACV ADULT AENEX AEUPB AEXZC AFFNX AFOSN AFRAH ALMA_UNASSIGNED_HOLDINGS AQVQM AS~ BKOMP CS3 D0L DCCCD DIK DOOOF DU5 E3Z EBS EJD F5P FRP GX1 H13 HGD HH5 HQ3 HTVGU HYE IPSME JAAYA JBMMH JENOY JHFFW JKQEH JLS JLXEF JPM JSG JSODD JST KQ8 L7B LU7 MVM N9A NEJ N~3 O9- OK1 P-O PNE PQQKQ R.V RHF RHI RNA RNS RPM RXW SA0 SJN TAE TN5 UKR VOH VQA W8F WH7 WHG WOQ WOW X7M XSW Y6R YBH YKV YSK ZCA ZCG ~02 ~KM - 02 08R 0R 1AW 55 AAPBV ABFLS ABPTK ADACO ADZLD AFDAS AJYGW AS ASUFR DNJUQ DWIUU DZ F20 GJ KM OHM PQEST X XFK XHC ZA5 CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QG 7QL 7QP 7QR 7SN 7SS 7T5 7TK 7TM 7TO 7U9 8FD C1K FR3 H94 M7N P64 RC3 5PM |
| ID | FETCH-LOGICAL-c612t-711a5541c6f6fbc7ca64393965975cac9ed0b2a9fd332cd4f272dbc18c04fc93 |
| IEDL.DBID | RPM |
| ISSN | 0027-8424 |
| IngestDate | Tue Sep 17 21:18:58 EDT 2024 Fri Oct 25 02:57:03 EDT 2024 Wed Nov 06 08:21:44 EST 2024 Fri Dec 06 04:29:26 EST 2024 Sat Nov 02 12:29:09 EDT 2024 Wed May 29 08:07:08 EDT 2019 Wed Nov 11 00:29:29 EST 2020 Tue Dec 10 23:06:19 EST 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 22 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c612t-711a5541c6f6fbc7ca64393965975cac9ed0b2a9fd332cd4f272dbc18c04fc93 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 R.T.F. and J.B. contributed equally to this work. Present address: Department of Neurology and Neurological Sciences, Stanford University School of Medicine, P211 MSLS, 1201 Welch Road, Stanford, CA 94305. To whom correspondence should be addressed. E-mail: edwards@itsa.ucsf.edu. Communicated by Roger A. Nicoll, University of California, San Francisco, CA |
| OpenAccessLink | https://europepmc.org/articles/pmc137910?pdf=render |
| PMID | 12388773 |
| PQID | 201295197 |
| PQPubID | 42026 |
| PageCount | 6 |
| ParticipantIDs | proquest_miscellaneous_18605678 jstor_primary_3073612 proquest_journals_201295197 pubmed_primary_12388773 pnas_primary_99_22_14488 pubmedcentral_primary_oai_pubmedcentral_nih_gov_137910 crossref_primary_10_1073_pnas_222546799 pnas_primary_99_22_14488_fulltext |
| ProviderPackageCode | RNA PNE |
| PublicationCentury | 2000 |
| PublicationDate | 2002-10-29 |
| PublicationDateYYYYMMDD | 2002-10-29 |
| PublicationDate_xml | – month: 10 year: 2002 text: 2002-10-29 day: 29 |
| PublicationDecade | 2000 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Washington |
| PublicationTitle | Proceedings of the National Academy of Sciences - PNAS |
| PublicationTitleAlternate | Proc Natl Acad Sci U S A |
| PublicationYear | 2002 |
| Publisher | National Academy of Sciences National Acad Sciences |
| Publisher_xml | – sequence: 0 name: National Academy of Sciences – name: National Acad Sciences – name: National Academy of Sciences |
| References | e_1_3_3_17_2 e_1_3_3_16_2 e_1_3_3_19_2 e_1_3_3_38_2 e_1_3_3_18_2 e_1_3_3_39_2 e_1_3_3_13_2 e_1_3_3_36_2 e_1_3_3_12_2 e_1_3_3_37_2 e_1_3_3_15_2 e_1_3_3_34_2 e_1_3_3_14_2 e_1_3_3_35_2 e_1_3_3_32_2 e_1_3_3_33_2 e_1_3_3_11_2 e_1_3_3_30_2 e_1_3_3_10_2 e_1_3_3_31_2 e_1_3_3_40_2 e_1_3_3_6_2 e_1_3_3_5_2 e_1_3_3_8_2 e_1_3_3_7_2 e_1_3_3_28_2 e_1_3_3_9_2 e_1_3_3_27_2 e_1_3_3_29_2 e_1_3_3_24_2 e_1_3_3_23_2 e_1_3_3_26_2 e_1_3_3_25_2 e_1_3_3_2_2 e_1_3_3_20_2 e_1_3_3_43_2 e_1_3_3_1_2 e_1_3_3_4_2 e_1_3_3_22_2 e_1_3_3_41_2 e_1_3_3_3_2 e_1_3_3_21_2 e_1_3_3_42_2 |
| References_xml | – ident: e_1_3_3_24_2 doi: 10.1074/jbc.M104578200 – ident: e_1_3_3_11_2 doi: 10.1016/S0896-6273(01)00344-0 – ident: e_1_3_3_26_2 doi: 10.1093/embo-reports/kvf159 – ident: e_1_3_3_31_2 doi: 10.1002/cne.903510305 – ident: e_1_3_3_9_2 doi: 10.1126/science.289.5481.957 – ident: e_1_3_3_29_2 doi: 10.1523/JNEUROSCI.18-23-09733.1998 – ident: e_1_3_3_23_2 doi: 10.1074/jbc.271.20.11726 – ident: e_1_3_3_30_2 doi: 10.1007/s004290050051 – ident: e_1_3_3_14_2 doi: 10.1002/cne.10129 – ident: e_1_3_3_28_2 doi: 10.1016/S0021-9258(18)83243-4 – ident: e_1_3_3_21_2 doi: 10.1016/S0092-8674(00)81674-8 – ident: e_1_3_3_36_2 doi: 10.1002/cne.903330309 – ident: e_1_3_3_43_2 doi: 10.1146/annurev.neuro.23.1.185 – ident: e_1_3_3_2_2 doi: 10.1126/science.1067020 – ident: e_1_3_3_3_2 doi: 10.1016/0197-0186(87)90176-8 – ident: e_1_3_3_41_2 doi: 10.1042/bj2670281 – ident: e_1_3_3_10_2 doi: 10.1038/35025070 – ident: e_1_3_3_27_2 doi: 10.1016/S0021-9258(19)37605-7 – ident: e_1_3_3_5_2 doi: 10.1002/jnr.10041 – ident: e_1_3_3_8_2 doi: 10.1016/0896-6273(95)90158-2 – ident: e_1_3_3_13_2 doi: 10.1523/JNEUROSCI.22-01-00142.2002 – ident: e_1_3_3_16_2 doi: 10.1016/0896-6273(94)90283-6 – ident: e_1_3_3_40_2 doi: 10.1074/jbc.271.29.17132 – ident: e_1_3_3_42_2 doi: 10.1038/360467a0 – ident: e_1_3_3_19_2 doi: 10.1523/JNEUROSCI.18-11-04022.1998 – ident: e_1_3_3_15_2 doi: 10.1523/JNEUROSCI.21-22-j0002.2001 – ident: e_1_3_3_22_2 doi: 10.1083/jcb.110.5.1693 – ident: e_1_3_3_1_2 doi: 10.1038/22768 – ident: e_1_3_3_7_2 doi: 10.1016/0896-6273(94)90038-8 – ident: e_1_3_3_35_2 doi: 10.1002/cne.903090308 – ident: e_1_3_3_4_2 doi: 10.1523/JNEUROSCI.15-12-08362.1995 – ident: e_1_3_3_18_2 doi: 10.1038/34651 – ident: e_1_3_3_25_2 doi: 10.1523/JNEUROSCI.22-13-05442.2002 – ident: e_1_3_3_32_2 doi: 10.1523/JNEUROSCI.12-04-01394.1992 – ident: e_1_3_3_39_2 doi: 10.1111/j.1469-7793.2000.00489.x – ident: e_1_3_3_17_2 doi: 10.1523/JNEUROSCI.18-12-04588.1998 – ident: e_1_3_3_34_2 doi: 10.1016/0166-2236(95)98374-8 – ident: e_1_3_3_37_2 doi: 10.1016/S0896-6273(00)81013-2 – ident: e_1_3_3_33_2 doi: 10.1002/cne.903260210 – ident: e_1_3_3_12_2 doi: 10.1523/JNEUROSCI.21-22-j0001.2001 – ident: e_1_3_3_20_2 doi: 10.1523/JNEUROSCI.20-02-00666.2000 – ident: e_1_3_3_6_2 doi: 10.1093/jn/131.9.2491S – ident: e_1_3_3_38_2 doi: 10.1073/pnas.101126398 |
| SSID | ssj0009580 |
| Score | 2.3562336 |
| Snippet | Quantal release of the principal excitatory neurotransmitter glutamate requires a mechanism for its transport into secretory vesicles. Within the brain, the... |
| SourceID | pubmedcentral proquest crossref pubmed pnas jstor |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 14488 |
| SubjectTerms | Amacrine cells Amino Acid Transport Systems, Acidic - genetics Amino Acid Transport Systems, Acidic - metabolism Animals Biological Sciences Blood vessels Brain - metabolism Brain - pathology Cell Membrane - metabolism Cell nucleus Dendrites Dendrites - metabolism Glutamic Acid - metabolism Hippocampus Humans Hydrogen-Ion Concentration Kidney - metabolism Kidney - pathology Liver - metabolism Liver - pathology Male Neuroglia Neurology Neurons PC12 Cells Purkinje cells Pyramidal cells Rats Signal Transduction Synapses Tissue Distribution Vesicular Glutamate Transport Proteins |
| Title | The Identification of Vesicular Glutamate Transporter 3 Suggests Novel Modes of Signaling by Glutamate |
| URI | https://www.jstor.org/stable/3073612 http://www.pnas.org/content/99/22/14488.abstract https://www.ncbi.nlm.nih.gov/pubmed/12388773 https://www.proquest.com/docview/201295197 https://search.proquest.com/docview/18605678 https://pubmed.ncbi.nlm.nih.gov/PMC137910 |
| Volume | 99 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9QwEB3RnrggCoWmXxgJCThkN7aTOD6iiqpCKuJQpN4i20nKSq131exW4t8z4zgpi-DCNfYklmfsmYnfPAO8QydllLUi5U0uUsy_ulRnNk8Ly5uysw3PDBUKX34tL77nX66L61gU1kdYpXd2MfO3dzO_-BGwlas7Nx9xYvNvl2dcKvRy8x3YQe87ZugT0W41lJ0I3H1zkY9EjUrOV970M8pvcHPQgS4U_VWllNzySQMskbhOsfvf4s4_4ZO_-aPz5_AsBpLs0zDgPXjS-hewF5dqzz5EPumPL6FDU2CLJsKCgibYsmMPbb8IIFR2g9ZnMHJt2XqiOr9nkvWbGzp96plfPrS3jC7N6UmSMB-GytiZ_fkovA9X55-vzi7SeL1C6jCsWaeKc4PBBHdlh1pxyhmKTiQxDKrCGafbJrPC6K6RUrgm74QSjXW8clneOS1fwa5f-vYAGDdOWI2hYOVsrjHnKAojS20qbVDVXCTwfpzfejWQaNTh8FvJmma5npSSwH6Y_qkbbUElveEgdBwfa40ymLbg9pPA23811V0E0CRwNKqxjmsUP0r_4KhuN4E3UysuLjoxMb5dbvqaV5jtoTtP4PWg8sfhR9NJoNwyhqkD0XZvt6A1B_ruwXoP_1fwCJ4ON9JkqdDHsLu-37QnGBit7Sm5peI0rIdf7pAPAg |
| link.rule.ids | 230,314,727,780,784,885,27924,27925,53791,53793 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3BbtQwEB1BOcAFUSg0lLZGQgIO2Y3tJI6PVdVqgW7FYZF6i2wnbldqs6tmtxJ_z9hx0i6iF25RPE4iz9gzE795BviETkoJrVlMq5TFmH_ZWCY6jTNNq9zqiibKFQpPz_PJr_T7RXYRisLaAKtsjJ6PmuubUTO_8tjK5Y0Z9zix8c_pMeUCvdz4KTzL3FWfow9Uu0VXeMJw_U1Z2lM1Cj5eNqoduQwHlwfpCUPRYxVC8A2v1AETHdspiv8r8vwbQPnAI52-gpchlCRH3Sdvw5O6eQ3bYbK25EtglP76BiwaA5lXARjkdUEWltzV7dzDUMkl2p_C2LUmq4Hs_JZw0q4v3f5TS5rFXX1N3LE5revpUB_KFbIT_fu-8w7MTk9mx5M4HLAQGwxsVrGgVGE4QU1uUS9GGOXiE-44BkVmlJF1lWimpK04Z6ZKLROs0oYWJkmtkfwtbDWLpt4FQpVhWmIwWBidSsw6skzxXKpCKlQ2ZRF87se3XHY0GqXf_ha8dKNcDkqJYMcP_yDmFqHcPWHXC_a3pcQ-mLjgAhTBx8eaShsgNBHs9WoswyzFl7q_cK5yN4LDoRWnl9szUU29WLclLTDfQ4cewbtO5fefH0wngnzDGAYBR9y92YL27Am8O_t9_78dD-H5ZDY9K8--nf_Ygxfd-TRJzOQH2Frdrut9DJNW-sDPij_tohFx |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB6VIiEuiEKhodAaCQk4ZBPbSRwfUcuqPFr1UKTeIj_idqU2u2p2K_HvGTuPdhG9cEw8TiLP2DMTf_MZ4AM6KSW0ZjG1GYsx_3KxTHUW55rawmlLU-ULhY9PiqNf2ffz_HwDyqEWJoD2jZ5NmqvrSTO7DNjKxbVJBpxYcnp8QLlAL5csrEseweMcr_iQp490u2VXfMJwDc5YNtA1Cp4sGtVOfJaDS4QMpKHotUoh-Jpn6sCJnvEUxf8Vff4NorznlabP4VkfTpIv3WdvwUbdvICtfsK25FPPKv35JTg0CDKzPTgo6IPMHbmt21mAopILtEGF8WtNliPh-Q3hpF1d-D2oljTz2_qK-KNzWt_TIz-UL2Yn-vdd5204m349OziK-0MWYoPBzTIWlCoMKagpHOrGCKN8jMI9z6DIjTKytqlmSjrLOTM2c0wwqw0tTZo5I_kr2GzmTb0DhCrDtMSAsDQ6k5h55LnihVSlVKhwyiL4OIxvteioNKqwBS545Ue5GpUSwXYY_lHML0SFf8JOEBxuS4l9MHnBRSiC9w81Va6H0USwO6ix6mcqvtT_ifPVuxHsj604xfy-iWrq-aqtaIk5Hzr1CF53Kr_7_N50IijWjGEU8OTd6y1o04HEu7PhN__bcR-enB5Oq5_fTn7swtPuiJo0ZvItbC5vVvU7jJSWei9Mij_VKhKE |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+identification+of+vesicular+glutamate+transporter+3+suggests+novel+modes+of+signaling+by+glutamate&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+-+PNAS&rft.au=Robert+T.+Fremeau%2C+Jr&rft.au=Jonathon+Burman&rft.au=Tayyaba+Qureshi&rft.au=Cindy+H.+Tran&rft.date=2002-10-29&rft.pub=National+Acad+Sciences&rft.issn=0027-8424&rft.eissn=1091-6490&rft.volume=99&rft.issue=22&rft.spage=14488&rft_id=info:doi/10.1073%2Fpnas.222546799&rft_id=info%3Apmid%2F12388773&rft.externalDBID=n%2Fa&rft.externalDocID=99_22_14488 |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.pnas.org%2Fcontent%2F99%2F22.cover.gif |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.pnas.org%2Fcontent%2F99%2F22.cover.gif |