Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification

• Published in: Neurobiology of disease Vol. 129; pp. 38 - 43
• Main Authors: Fenyi, Alexis, Leclair-Visonneau, Laurène, Clairembault, Thomas, Coron, Emmanuel, Neunlist, Michel, Melki, Ronald, Derkinderen, Pascal, Bousset, Luc
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2019; Elsevier
• Subjects: Adult; Aged; Alpha-synuclein; alpha-Synuclein - analysis; Biochemistry, Molecular Biology; Biopsy; Enteric nervous system; Female; Gastrointestinal Tract - pathology; Gut; Humans; Life Sciences; Male; Middle Aged; Neurons and Cognition; Nucleic Acid Amplification Techniques - methods; Parkinson Disease - diagnosis; Parkinson Disease - pathology; Parkinson's disease; Protein misfolding cyclic amplification; ThT; GI; Parkinson's disease; PASH; Gut; CNS; aSyn; ENS; Protein misfolding cyclic amplification; Enteric nervous system; PD; Biopsy; FFPE; PGP9.5; CSF; Alpha-synuclein; PMCA

Lewy bodies and neurites, the pathological signatures found in the central nervous system of Parkinson's disease (PD) patients, are primarily composed of aggregated alpha-synuclein (aSyn). The observation that aSyn aggregates are also found in the enteric nervous system has prompted several stu...