Effect of Prophylactic Vaccination with the Membrane-Bound Acid Phosphatase Gene of Leishmania mexicana in the Murine Model of Localized Cutaneous Leishmaniasis

• Published in: Journal of Immunology Research Vol. 2021; pp. 6624246 - 13
• Main Authors: Burgos-Reyes, María Angélica, Baylón-Pacheco, Lidia, Espíritu-Gordillo, Patricia, Galindo-Gómez, Silvia, Tsutsumi, Víctor, Rosales-Encina, José Luis
• Format: Journal Article
• Language: English
• Published: Egypt Hindawi 2021; Hindawi Limited; Wiley
• Subjects: Acid phosphatase; Analysis; Animal models; Antibodies; Antigens; Chromatography; Cloning; Connective tissues; Cutaneous leishmaniasis; Deoxyribonucleic acid; Dermis; DNA; DNA vaccines; E coli; Experimental infection; Genes; Health aspects; Immunoglobulin G; Immunology; Infections; Laboratory animals; Leishmania mexicana; Leishmaniasis, Cutaneous; Lymphocytes; Parasites; Parasitic diseases; Phosphatase; Phosphatases; Photographic industry; Plasmids; Proteins; Protozoa; Tropical diseases; Tumor necrosis factor-TNF; Vaccination; Vaccines; Japan; United States > US

Leishmaniasis is a disease caused by an intracellular protozoan parasite of the genus Leishmania. Current treatments for leishmaniasis are long, toxic, and expensive and are not available in some endemic regions. Attempts to develop an effective vaccine are feasible, but no vaccine is in active clin...