Light-Inducible and Clock-Controlled Expression of MAP Kinase Phosphatase 1 in Mouse Central Pacemaker Neurons

• Published in: Journal of biological rhythms Vol. 22; no. 2; pp. 127 - 139
• Main Authors: Doi, Masao, Cho, Sehyung, Yujnovsky, Irene, Hirayama, Jun, Cermakian, Nicolas, Cato, Andrew C.B, Sassone-Corsi, Paolo
• Format: Journal Article
• Language: English
• Published: United States SAGE Publications 01.04.2007
• Subjects: Animals; ARNTL Transcription Factors; Basic Helix-Loop-Helix Transcription Factors - physiology; Biological Clocks - physiology; Cell Cycle Proteins - biosynthesis; CLOCK Proteins; Cyclic AMP Response Element-Binding Protein - metabolism; Dual Specificity Phosphatase 1; Gene Expression Regulation - radiation effects; Immediate-Early Proteins - biosynthesis; Light; MAP Kinase Signaling System - physiology; Mice; Neurons - enzymology; Nuclear Proteins - biosynthesis; Period Circadian Proteins; Phosphoprotein Phosphatases - biosynthesis; Promoter Regions, Genetic; Protein Phosphatase 1; Protein Tyrosine Phosphatases - biosynthesis; Response Elements - physiology; Suprachiasmatic Nucleus - enzymology; Suprachiasmatic Nucleus - radiation effects; Trans-Activators - physiology; Transcription Factors - biosynthesis

MAP kinase phosphatase 1 (MKP1) is a negative regulator for the mitogen-activated protein kinase (MAPK)--mediated signal transduction, a key pathway that leads to the regulated expression of circadian clock genes. Here the authors analyzed mkp1 expression by in situ hybridization and found that mkp1...