Scavenger receptor B2 is a cellular receptor for enterovirus 71

• Published in: Nature medicine Vol. 15; no. 7; pp. 798 - 801
• Main Authors: Yamayoshi, Seiya, Yamashita, Yasuko, Li, Jifen, Hanagata, Nobutaka, Minowa, Takashi, Takemura, Taro, Koike, Satoshi
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.07.2009; Nature Publishing Group
• Subjects: Animals; Antibodies; Binding sites; Biomedical and Life Sciences; Biomedicine; Cancer Research; Cell receptors; Cellular biology; Coxsackievirus; Enterovirus; Enterovirus A, Human - pathogenicity; Enterovirus diseases; Epidemics; Epidemiology; Gene Expression Profiling; Humans; Infectious Diseases; letter; Lysosomal Membrane Proteins - analysis; Lysosomal Membrane Proteins - genetics; Lysosomal Membrane Proteins - physiology; Metabolic Diseases; Mice; Molecular Medicine; Neurosciences; Outbreaks; Pathogens; Physiological aspects; Picornaviridae; Proteins; Receptors, Scavenger - analysis; Receptors, Scavenger - genetics; Receptors, Scavenger - physiology; Receptors, Virus - analysis; Receptors, Virus - physiology; Rhabdomyosarcoma - virology; Risk factors; Viral antibodies; Viruses; Japan; Asia

Enterovirus 71 (EV71) causes hand, foot and mouth disease, a mild infectious disease that can, however, occasionally lead to severe neurological impairments. These two studies, by Nishimura et al . and Yamayoshi et al ., independently identify two different receptors for EV71—P-selectin glycoprotein...