The Role of β-Catenin in Th1 Immune Response against Tuberculosis and Profiles of Expression in Patients with Pulmonary Tuberculosis

• Published in: Journal of Immunology Research Vol. 2021; pp. 6625855 - 15
• Main Authors: Xiong, Kunlong, Niu, Jinxia, Zheng, Ruijuan, Liu, Zhonghua, Song, Yanzheng, Wang, Lin, Zhu, Changtai, Fan, Lin
• Format: Journal Article
• Language: English
• Published: Egypt Hindawi 11.02.2021; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Antibodies; BCG; BCG vaccines; CD4 antigen; CD8 antigen; Cloning; Cytokines; Flow cytometry; Gene expression; Health aspects; Immunology; Infections; Inflammation; Laboratory animals; Leukocytes (mononuclear); Lithium; Lithium chloride; Lungs; Lymphocytes; Lymphocytes T; PD-1 protein; Peripheral blood mononuclear cells; Physiological aspects; Pulmonary tuberculosis; RNA; T cells; Transcription factors; Tuberculosis; Tumor necrosis factor; Tumor necrosis factor-α; Wnt protein; β-Catenin; γ-Interferon; China; United States > US

β-Catenin is a key molecule of canonical Wnt/β-catenin pathway. Its roles and expression profiles in T cells of tuberculosis (TB) remain unclear. The aim of this study was to explore the role of β-catenin in CD4+ T cells and its expression characteristics in patients with pulmonary tuberculosis (PTB...