The Role of β-Catenin in Th1 Immune Response against Tuberculosis and Profiles of Expression in Patients with Pulmonary Tuberculosis
β-Catenin is a key molecule of canonical Wnt/β-catenin pathway. Its roles and expression profiles in T cells of tuberculosis (TB) remain unclear. The aim of this study was to explore the role of β-catenin in CD4+ T cells and its expression characteristics in patients with pulmonary tuberculosis (PTB...
Saved in:
Published in | Journal of Immunology Research Vol. 2021; pp. 6625855 - 15 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Egypt
Hindawi
11.02.2021
John Wiley & Sons, Inc Hindawi Limited |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | β-Catenin is a key molecule of canonical Wnt/β-catenin pathway. Its roles and expression profiles in T cells of tuberculosis (TB) remain unclear. The aim of this study was to explore the role of β-catenin in CD4+ T cells and its expression characteristics in patients with pulmonary tuberculosis (PTB). In this study, CD4+ T cell-specific β-catenin conditional knockout mice (β-CAT-cKO mice) were aerosol infected with Mycobacteria tuberculosis (Mtb) H37RV with wild-type mice as controls. Four weeks after infection, the mRNA expression of IFN-γ, TNF-α, and TCF-7 in the lungs of mice was measured. CD4, CD8, β-catenin, IFN-γ, and TNF-α in mononuclear cells from the lungs and spleens were measured by flow cytometry, and the pathological changes of lungs were also observed. Patients with PTB were enrolled, with blood samples collected and PBMCs isolated. The expressions of β-catenin, IFN-γ, TNF-α, and PD-1 in CD4+ and CD8+ T cells were measured by flow cytometry. Results showed a decreased frequency of and reduced IFN-γ/TNF-α mRNA expression and secretion by CD4+ T cells in the lungs of infected β-CAT-cKO mice compared with infected wild-type controls, and only slightly more inflammatory changes were observed in the lungs. β-catenin expressions in CD4+ and CD8+ T cells were significantly decreased in blood cells of patients with severe PTB compared with those in mild PTB. The stimulation of peripheral blood mononuclear cells (PBMCs) with lithium chloride (LiCl), a stimulant of β-catenin, resulted in the increase in CD4+ T cell frequency, as well as their secretion of IFN-γ and TNF-α. β-Catenin demonstrated a moderately positive correlation with PD-1 in CD4+ T cells. β-Catenin along with PD-1 and IFN-γ in CD4+ T cells had a high correlation with those in CD8+ T cells. In conclusion, β-catenin may be involved in the regulation of Th1 response and CD4+ T cell frequency in TB. |
---|---|
AbstractList | β -Catenin is a key molecule of canonical Wnt/β -catenin pathway. Its roles and expression profiles in T cells of tuberculosis (TB) remain unclear. The aim of this study was to explore the role of β -catenin in CD4[sup.+] T cells and its expression characteristics in patients with pulmonary tuberculosis (PTB). In this study, CD4[sup.+] T cell-specific β -catenin conditional knockout mice (β -CAT-cKO mice) were aerosol infected with Mycobacteria tuberculosis (Mtb) H37R[sub.V] with wild-type mice as controls. Four weeks after infection, the mRNA expression of IFN-γ , TNF-α , and TCF-7 in the lungs of mice was measured. CD4, CD8, β -catenin, IFN-γ , and TNF-α in mononuclear cells from the lungs and spleens were measured by flow cytometry, and the pathological changes of lungs were also observed. Patients with PTB were enrolled, with blood samples collected and PBMCs isolated. The expressions of β -catenin, IFN-γ , TNF-α , and PD-1 in CD4[sup.+] and CD8[sup.+] T cells were measured by flow cytometry. Results showed a decreased frequency of and reduced IFN-γ /TNF-α mRNA expression and secretion by CD4[sup.+] T cells in the lungs of infected β -CAT-cKO mice compared with infected wild-type controls, and only slightly more inflammatory changes were observed in the lungs. β -catenin expressions in CD4[sup.+] and CD8[sup.+] T cells were significantly decreased in blood cells of patients with severe PTB compared with those in mild PTB. The stimulation of peripheral blood mononuclear cells (PBMCs) with lithium chloride (LiCl), a stimulant of β -catenin, resulted in the increase in CD4[sup.+] T cell frequency, as well as their secretion of IFN-γ and TNF-α . β -Catenin demonstrated a moderately positive correlation with PD-1 in CD4[sup.+] T cells. β -Catenin along with PD-1 and IFN-γ in CD4[sup.+] T cells had a high correlation with those in CD8[sup.+] T cells. In conclusion, β -catenin may be involved in the regulation of Th1 response and CD4[sup.+] T cell frequency in TB. β -Catenin is a key molecule of canonical Wnt/ β -catenin pathway. Its roles and expression profiles in T cells of tuberculosis (TB) remain unclear. The aim of this study was to explore the role of β -catenin in CD4 + T cells and its expression characteristics in patients with pulmonary tuberculosis (PTB). In this study, CD4 + T cell-specific β -catenin conditional knockout mice ( β -CAT-cKO mice) were aerosol infected with Mycobacteria tuberculosis ( Mtb ) H37R V with wild-type mice as controls. Four weeks after infection, the mRNA expression of IFN- γ , TNF- α , and TCF-7 in the lungs of mice was measured. CD4, CD8, β -catenin, IFN- γ , and TNF- α in mononuclear cells from the lungs and spleens were measured by flow cytometry, and the pathological changes of lungs were also observed. Patients with PTB were enrolled, with blood samples collected and PBMCs isolated. The expressions of β -catenin, IFN- γ , TNF- α , and PD-1 in CD4 + and CD8 + T cells were measured by flow cytometry. Results showed a decreased frequency of and reduced IFN- γ /TNF- α mRNA expression and secretion by CD4 + T cells in the lungs of infected β -CAT-cKO mice compared with infected wild-type controls, and only slightly more inflammatory changes were observed in the lungs. β -catenin expressions in CD4 + and CD8 + T cells were significantly decreased in blood cells of patients with severe PTB compared with those in mild PTB. The stimulation of peripheral blood mononuclear cells (PBMCs) with lithium chloride (LiCl), a stimulant of β -catenin, resulted in the increase in CD4 + T cell frequency, as well as their secretion of IFN- γ and TNF- α . β -Catenin demonstrated a moderately positive correlation with PD-1 in CD4 + T cells. β -Catenin along with PD-1 and IFN- γ in CD4 + T cells had a high correlation with those in CD8 + T cells. In conclusion, β -catenin may be involved in the regulation of Th1 response and CD4 + T cell frequency in TB. β-Catenin is a key molecule of canonical Wnt/β-catenin pathway. Its roles and expression profiles in T cells of tuberculosis (TB) remain unclear. The aim of this study was to explore the role of β-catenin in CD4+ T cells and its expression characteristics in patients with pulmonary tuberculosis (PTB). In this study, CD4+ T cell-specific β-catenin conditional knockout mice (β-CAT-cKO mice) were aerosol infected with Mycobacteria tuberculosis (Mtb) H37RV with wild-type mice as controls. Four weeks after infection, the mRNA expression of IFN-γ, TNF-α, and TCF-7 in the lungs of mice was measured. CD4, CD8, β-catenin, IFN-γ, and TNF-α in mononuclear cells from the lungs and spleens were measured by flow cytometry, and the pathological changes of lungs were also observed. Patients with PTB were enrolled, with blood samples collected and PBMCs isolated. The expressions of β-catenin, IFN-γ, TNF-α, and PD-1 in CD4+ and CD8+ T cells were measured by flow cytometry. Results showed a decreased frequency of and reduced IFN-γ/TNF-α mRNA expression and secretion by CD4+ T cells in the lungs of infected β-CAT-cKO mice compared with infected wild-type controls, and only slightly more inflammatory changes were observed in the lungs. β-catenin expressions in CD4+ and CD8+ T cells were significantly decreased in blood cells of patients with severe PTB compared with those in mild PTB. The stimulation of peripheral blood mononuclear cells (PBMCs) with lithium chloride (LiCl), a stimulant of β-catenin, resulted in the increase in CD4+ T cell frequency, as well as their secretion of IFN-γ and TNF-α. β-Catenin demonstrated a moderately positive correlation with PD-1 in CD4+ T cells. β-Catenin along with PD-1 and IFN-γ in CD4+ T cells had a high correlation with those in CD8+ T cells. In conclusion, β-catenin may be involved in the regulation of Th1 response and CD4+ T cell frequency in TB. -Catenin is a key molecule of canonical Wnt/ -catenin pathway. Its roles and expression profiles in T cells of tuberculosis (TB) remain unclear. The aim of this study was to explore the role of -catenin in CD4 T cells and its expression characteristics in patients with pulmonary tuberculosis (PTB). In this study, CD4 T cell-specific -catenin conditional knockout mice ( -CAT-cKO mice) were aerosol infected with ( ) H37R with wild-type mice as controls. Four weeks after infection, the mRNA expression of IFN- , TNF- , and TCF-7 in the lungs of mice was measured. CD4, CD8, -catenin, IFN- , and TNF- in mononuclear cells from the lungs and spleens were measured by flow cytometry, and the pathological changes of lungs were also observed. Patients with PTB were enrolled, with blood samples collected and PBMCs isolated. The expressions of -catenin, IFN- , TNF- , and PD-1 in CD4 and CD8 T cells were measured by flow cytometry. Results showed a decreased frequency of and reduced IFN- /TNF- mRNA expression and secretion by CD4 T cells in the lungs of infected -CAT-cKO mice compared with infected wild-type controls, and only slightly more inflammatory changes were observed in the lungs. -catenin expressions in CD4 and CD8 T cells were significantly decreased in blood cells of patients with severe PTB compared with those in mild PTB. The stimulation of peripheral blood mononuclear cells (PBMCs) with lithium chloride (LiCl), a stimulant of -catenin, resulted in the increase in CD4 T cell frequency, as well as their secretion of IFN- and TNF- . -Catenin demonstrated a moderately positive correlation with PD-1 in CD4 T cells. -Catenin along with PD-1 and IFN- in CD4 T cells had a high correlation with those in CD8 T cells. In conclusion, -catenin may be involved in the regulation of Th1 response and CD4 T cell frequency in TB. |
Audience | Academic |
Author | Xiong, Kunlong Song, Yanzheng Fan, Lin Liu, Zhonghua Zhu, Changtai Zheng, Ruijuan Wang, Lin Niu, Jinxia |
AuthorAffiliation | 2 Shanghai Public Health Clinical Center, Shanghai, China 3 Department of Laboratory Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China 1 Shanghai Clinical Research Center for Tuberculosis, Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China |
AuthorAffiliation_xml | – name: 2 Shanghai Public Health Clinical Center, Shanghai, China – name: 1 Shanghai Clinical Research Center for Tuberculosis, Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China – name: 3 Department of Laboratory Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China |
Author_xml | – sequence: 1 givenname: Kunlong surname: Xiong fullname: Xiong, Kunlong organization: Shanghai Clinical Research Center for TuberculosisShanghai Key Lab of TuberculosisShanghai Pulmonary HospitalTongji University School of MedicineShanghaiChinatongji.edu.cn – sequence: 2 givenname: Jinxia surname: Niu fullname: Niu, Jinxia organization: Shanghai Clinical Research Center for TuberculosisShanghai Key Lab of TuberculosisShanghai Pulmonary HospitalTongji University School of MedicineShanghaiChinatongji.edu.cn – sequence: 3 givenname: Ruijuan surname: Zheng fullname: Zheng, Ruijuan organization: Shanghai Clinical Research Center for TuberculosisShanghai Key Lab of TuberculosisShanghai Pulmonary HospitalTongji University School of MedicineShanghaiChinatongji.edu.cn – sequence: 4 givenname: Zhonghua surname: Liu fullname: Liu, Zhonghua organization: Shanghai Clinical Research Center for TuberculosisShanghai Key Lab of TuberculosisShanghai Pulmonary HospitalTongji University School of MedicineShanghaiChinatongji.edu.cn – sequence: 5 givenname: Yanzheng surname: Song fullname: Song, Yanzheng organization: Shanghai Public Health Clinical CenterShanghaiChinashaphc.org – sequence: 6 givenname: Lin orcidid: 0000-0001-5171-2663 surname: Wang fullname: Wang, Lin organization: Shanghai Public Health Clinical CenterShanghaiChinashaphc.org – sequence: 7 givenname: Changtai orcidid: 0000-0002-5250-1937 surname: Zhu fullname: Zhu, Changtai organization: Department of Laboratory MedicineShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghaiChinasjtu.edu.cn – sequence: 8 givenname: Lin orcidid: 0000-0002-9411-496X surname: Fan fullname: Fan, Lin organization: Shanghai Clinical Research Center for TuberculosisShanghai Key Lab of TuberculosisShanghai Pulmonary HospitalTongji University School of MedicineShanghaiChinatongji.edu.cn |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33628846$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kttqFDEchwep2Fp757UMCCLotjlMTjdCWaouFCyyXoecZidlJlmTGasP4Av5ID6T2e5auyKSQMLky5fJP7_H1UGIwVXVUwhOISTkDAEEzyhFhBPyoDpCGDYzBgk92M05p_CwOsnZa0AAw5hy-qg6LCPivKFH1fdl5-qPsXd1bOufP2ZzNbrgQ136soP1YhimUACX1zFkV6uV8iGP9XLSLpmpj9nnWgVbX6XY-t7ljebi6zq5cmS81Vyp0bsw5vrGj119NfVDDCp921M8qR62qs_uZDceV5_eXizn72eXH94t5ueXM0MhGmfYQAs15gBq3WoAW8sIcY1ogXCNIoxTS7RQHHBMNBS4rAtOgVFaA2CJwMfVYuu1UV3LdfJD-RMZlZe3H2JaSZVGb3onccsBpppxC0zDDBBUceQssZA5xqAtrjdb13rSg7Om3DGpfk-6vxJ8J1fxi2RcIIRwEbzcCVL8PLk8ysFn4_peBRenLFEjcNMISnlBn_-FXscphVKqDQVZIwhnf6iVKhfwoY3lXLORynMqqMCCEVSo039QpVk3eFPitXnH_Q0v7m3onOrHLsd-GssD533w9RY0KeacXHtXDAjkJq5yE1e5i2vBn90v4B38O5wFeLUFOh-suvH_1_0CQ1XzKA |
CitedBy_id | crossref_primary_10_1371_journal_ppat_1009278 |
Cites_doi | 10.1042/BCJ20200099 10.1371/journal.pone.0127087 10.1016/j.biopha.2019.108921 10.1126/science.1218370 10.3389/fimmu.2019.02293 10.3389/fimmu.2017.00050 10.3389/fimmu.2019.02135 10.1371/journal.pone.0172549 10.1126/sciadv.aau5240 10.1007/s12026-009-8137-2 10.1016/j.celrep.2020.01.059 10.4049/jimmunol.176.8.4880 10.1002/bies.201900099 10.1101/cshperspect.a018465 10.1016/j.ymthe.2019.12.013 10.1016/j.micpath.2018.12.016 10.3390/cancers12020345 10.1093/infdis/jiu472 10.3390/ijms15035045 10.18632/oncotarget.25093 10.1158/2159-8290.CD-19-0074 10.1186/s12865-015-0080-5 10.1038/s41467-020-14442-6 10.1016/j.tube.2011.04.001 10.3390/cancers12030766 |
ContentType | Journal Article |
Copyright | Copyright © 2021 Kunlong Xiong et al. COPYRIGHT 2021 John Wiley & Sons, Inc. Copyright © 2021 Kunlong Xiong et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0 Copyright © 2021 Kunlong Xiong et al. 2021 |
Copyright_xml | – notice: Copyright © 2021 Kunlong Xiong et al. – notice: COPYRIGHT 2021 John Wiley & Sons, Inc. – notice: Copyright © 2021 Kunlong Xiong et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0 – notice: Copyright © 2021 Kunlong Xiong et al. 2021 |
DBID | RHU RHW RHX NPM AAYXX CITATION 3V. 7T5 7X7 7XB 88E 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU CWDGH DWQXO FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7P PIMPY PQEST PQQKQ PQUKI PRINS 7X8 5PM DOA |
DOI | 10.1155/2021/6625855 |
DatabaseName | Hindawi Publishing Complete Hindawi Publishing Subscription Journals Hindawi Publishing Open Access PubMed CrossRef ProQuest Central (Corporate) Immunology Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College Middle East & Africa Database ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Biological Science Database Publicly Available Content (ProQuest) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) Directory of Open Access Journals |
DatabaseTitle | PubMed CrossRef Publicly Available Content Database ProQuest Central Student ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Central China ProQuest Central Health Research Premium Collection Middle East & Africa Database Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Biological Science Collection AIDS and Cancer Research Abstracts ProQuest Medical Library (Alumni) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Immunology Abstracts ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | Publicly Available Content Database CrossRef PubMed |
Database_xml | – sequence: 1 dbid: RHX name: Hindawi Publishing Open Access url: http://www.hindawi.com/journals/ sourceTypes: Publisher – sequence: 2 dbid: DOA name: Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: BENPR name: AUTh Library subscriptions: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Biology |
EISSN | 2314-7156 |
Editor | Delpino, M. Victoria |
Editor_xml | – sequence: 1 givenname: M. Victoria surname: Delpino fullname: Delpino, M. Victoria – fullname: M Victoria Delpino |
EndPage | 15 |
ExternalDocumentID | oai_doaj_org_article_3f8036b78d0c47c096a82ed5d17e771d A696939752 10_1155_2021_6625855 33628846 |
Genre | Journal Article |
GeographicLocations | China United States--US |
GeographicLocations_xml | – name: China – name: United States--US |
GrantInformation_xml | – fundername: Science and Technology Commission of Shanghai Municipality grantid: 20ZR1446700 – fundername: 13th Five-Year National Science and Technology Major Project for Infectious Diseases, China grantid: 2018ZX10725-509 |
GroupedDBID | 3V. 53G 5VS 7X7 7XC 88E 8FE 8FH 8FI 8FJ AAFWJ AAJEY AAKDD ABDBF ABUWG ACPRK ADBBV ADRAZ AENEX AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS B0M BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI CCPQU CWDGH DIK EAD EAP EBD EBS EJD EMB EMK EMOBN EPL ESX FYUFA GROUPED_DOAJ HCIFZ HMCUK HYE IAO IEA IHR IHW INH INR ITC KQ8 LK8 M1P M48 M7P OK1 PIMPY PQQKQ PROAC PSQYO RHU RHW RHX RPM SV3 TUS UKHRP ~8M 24P ALIPV H13 NPM PGMZT AAYXX CITATION M~E 7T5 7XB 8FK AZQEC DWQXO GNUQQ H94 K9. PQEST PQUKI PRINS 7X8 5PM |
ID | FETCH-LOGICAL-c612t-3c1d1b3801bbfb01fd755e49f09e4a5786d5b9a80835b193fd79860cabb00d593 |
IEDL.DBID | RPM |
ISSN | 2314-8861 |
IngestDate | Mon Nov 04 19:57:58 EST 2024 Tue Sep 17 21:19:22 EDT 2024 Sat Aug 17 00:25:50 EDT 2024 Thu Oct 10 22:21:45 EDT 2024 Wed Oct 16 18:04:21 EDT 2024 Tue Oct 15 04:47:33 EDT 2024 Tue Oct 15 02:43:20 EDT 2024 Fri Dec 06 13:17:14 EST 2024 Sat Sep 28 08:25:30 EDT 2024 Sun Jun 02 18:51:30 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Language | English |
License | This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2021 Kunlong Xiong et al. https://creativecommons.org/licenses/by/4.0 |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c612t-3c1d1b3801bbfb01fd755e49f09e4a5786d5b9a80835b193fd79860cabb00d593 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Academic Editor: M. Victoria Delpino |
ORCID | 0000-0002-5250-1937 0000-0002-9411-496X 0000-0001-5171-2663 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892223/ |
PMID | 33628846 |
PQID | 2491749587 |
PQPubID | 237305 |
PageCount | 15 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_3f8036b78d0c47c096a82ed5d17e771d pubmedcentral_primary_oai_pubmedcentral_nih_gov_7892223 proquest_miscellaneous_2493449668 proquest_journals_2491749587 gale_infotracmisc_A696939752 gale_infotracacademiconefile_A696939752 gale_healthsolutions_A696939752 crossref_primary_10_1155_2021_6625855 pubmed_primary_33628846 hindawi_primary_10_1155_2021_6625855 |
PublicationCentury | 2000 |
PublicationDate | 2021-02-11 |
PublicationDateYYYYMMDD | 2021-02-11 |
PublicationDate_xml | – month: 02 year: 2021 text: 2021-02-11 day: 11 |
PublicationDecade | 2020 |
PublicationPlace | Egypt |
PublicationPlace_xml | – name: Egypt – name: New York |
PublicationTitle | Journal of Immunology Research |
PublicationTitleAlternate | J Immunol Res |
PublicationYear | 2021 |
Publisher | Hindawi John Wiley & Sons, Inc Hindawi Limited |
Publisher_xml | – name: Hindawi – name: John Wiley & Sons, Inc – name: Hindawi Limited |
References | 22 23 24 25 26 W. J. Zhou (13) 2016; 47 10 11 12 14 15 16 17 18 19 1 2 3 4 5 6 7 8 9 20 21 |
References_xml | – ident: 18 doi: 10.1042/BCJ20200099 – ident: 14 doi: 10.1371/journal.pone.0127087 – ident: 22 doi: 10.1016/j.biopha.2019.108921 – ident: 5 doi: 10.1126/science.1218370 – ident: 21 doi: 10.3389/fimmu.2019.02293 – ident: 1 doi: 10.3389/fimmu.2017.00050 – ident: 9 doi: 10.3389/fimmu.2019.02135 – ident: 15 doi: 10.1371/journal.pone.0172549 – ident: 24 doi: 10.1126/sciadv.aau5240 – ident: 3 doi: 10.1007/s12026-009-8137-2 – ident: 16 doi: 10.1016/j.celrep.2020.01.059 – ident: 4 doi: 10.4049/jimmunol.176.8.4880 – ident: 17 doi: 10.1002/bies.201900099 – ident: 2 doi: 10.1101/cshperspect.a018465 – ident: 7 doi: 10.1016/j.ymthe.2019.12.013 – ident: 11 doi: 10.1016/j.micpath.2018.12.016 – volume: 47 start-page: 920 year: 2016 ident: 13 article-title: Association of gene polymorphisms in Wnt signal pathway with tuberculosis in Chinese Tibetan population publication-title: Sichuan Da Xue Xue Bao Yi Xue Ban contributor: fullname: W. J. Zhou – ident: 6 doi: 10.3390/cancers12020345 – ident: 25 doi: 10.1093/infdis/jiu472 – ident: 12 doi: 10.3390/ijms15035045 – ident: 8 doi: 10.18632/oncotarget.25093 – ident: 23 doi: 10.1158/2159-8290.CD-19-0074 – ident: 10 doi: 10.1186/s12865-015-0080-5 – ident: 19 doi: 10.1038/s41467-020-14442-6 – ident: 26 doi: 10.1016/j.tube.2011.04.001 – ident: 20 doi: 10.3390/cancers12030766 |
SSID | ssib050733686 ssj0001213421 |
Score | 2.3054361 |
Snippet | β-Catenin is a key molecule of canonical Wnt/β-catenin pathway. Its roles and expression profiles in T cells of tuberculosis (TB) remain unclear. The aim of... -Catenin is a key molecule of canonical Wnt/ -catenin pathway. Its roles and expression profiles in T cells of tuberculosis (TB) remain unclear. The aim of... β -Catenin is a key molecule of canonical Wnt/β -catenin pathway. Its roles and expression profiles in T cells of tuberculosis (TB) remain unclear. The aim of... β -Catenin is a key molecule of canonical Wnt/ β -catenin pathway. Its roles and expression profiles in T cells of tuberculosis (TB) remain unclear. The aim of... |
SourceID | doaj pubmedcentral proquest gale crossref pubmed hindawi |
SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 6625855 |
SubjectTerms | Antibodies BCG BCG vaccines CD4 antigen CD8 antigen Cloning Cytokines Flow cytometry Gene expression Health aspects Immunology Infections Inflammation Laboratory animals Leukocytes (mononuclear) Lithium Lithium chloride Lungs Lymphocytes Lymphocytes T PD-1 protein Peripheral blood mononuclear cells Physiological aspects Pulmonary tuberculosis RNA T cells Transcription factors Tuberculosis Tumor necrosis factor Tumor necrosis factor-α Wnt protein β-Catenin γ-Interferon |
SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3bihQxEA2ysOCLeLd11AgrPjU76c71cV12WQVlkFnYtya3dgeGHpkLuh_gD_khfpNVSc8wLcK-CPM0KdKk6lRyKlRVCDkK3ijjjS_RHUsuY1sap31po2WVdy5UqYHpp8_y4pJ_vBJXe099YU5Ybg-cFXdctxo2Wad0GHuuPDBuq6sYRGAqKsVC2n3H1V4wBUgS-BSh7Buj5dsWVvNUhAV8hpdaS7bNghcCLwDYsYRIQGPF3975lNr47zbrw2sMk7_P_kVG_86p3Dukzu-Tez27pCd5VQ_Indg9JIf5vcmbR-QngIJ-WcwjXbT096_yFIhmN-so_KbXjH7AWhEQyGmzkdqvdgbskU43Li79Zr5YzVbUdoFO8kPfK5zm7EefSpummeQ2rSuK97t0spkDyu3yZjDFY3J5fjY9vSj7dxhKD_xnXdaeBeZqOMuca92YtUEJEblpxyZyCy4vg3DGamRzDgghjBstx9468OkgTP2EHHSLLj4jNFhZBV9DWFobbirrlOQgpKLWQVpeF-TtVvvNt9xuo0lhihANWqnprVSQ92ianQw2yU5_AHSaHjrNbdApyGs0bJMrTneu3pxIIw3wNFEV5F2SQGcHq3rb1yzAYlDNA8nRQBKc1A-Gj3rw3LKs0RZZTb-XrBoIkCFsNEKrgrzZDeMHMD-ui4tNkqk5h9BVF-RpBuLuQ-AJlQaaWRA1gOhAecORbnadOo0rbZA_Pv8f2n5B7uJSMeOdsRE5WC838SUQurV7lXz3D2-HQ5c priority: 102 providerName: Directory of Open Access Journals – databaseName: Hindawi Publishing Open Access dbid: RHX link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3datRAFB5soeCN-G_sqiNUvAruJPN7WUvLKihL2cLehfmLG1gS2exi-wC-kA_iM3lmkg2mCgq5SeYwSeacL-c7kzNnEDpxVglllU0DHFPKfZkqI22qvSaZNcZlsYDpp898dkU_LtmyL5LU_vkLH7xdCM_JOw48XTJ2gA6kCJlbl7Pl3mxY2HeQ91XQuqkVktO44grIC02l5GSf8n6ru5EzijX7hy_z0SrExN-qvzHP2wmUv3mki_voXk8l8Wmn-wfojq8foqNuc8mbR-g7WAC-bNYeNyX--SM9A1ZZVzWGY7Ei-ENYGAICXY6sx_qLroAq4sXO-I3drZu2arGuHZ53u3q3oZvz6z5vNnYz72qytjhM5uL5bg0mrTc3oy4eo6uL88XZLO03XUgtkJ1tmlviiMnBcRlTmikpnWDMU1VOlaca8M0dM0rLQN0MsD9oV5JPrTYAYMdU_gQd1k3tnyHsNM-czSEGzRVVmTaCUxASXkrHNc0T9GY_-sXXrrZGEWMSxoqgpaLXUoLeB9UMMqEidrwAVlL0ACvyUoIzNkK6qaXCQmSmZeYdc0R4IYhL0Kug2KJbXjrgujjliisgZSxL0NsoEZANWrW6X6AALxOGeSQ5GUkCIu2o-aQ3nn-81mRvWUX_4WgLiIYhRlRMigS9HprDDUIyXO2bXZTJKYU4VSboaWeIw40ACZkETpkgMTLR0eCNW-pqFcuKC6kCWXz-f09_jO6G05DATsgEHW43O_8C-NnWvIzo_AWntDEf priority: 102 providerName: Hindawi Publishing – databaseName: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3battAEF1ah0BfSu9V67ZbSOmTiFfa61NJgkNaaDDBgbyJvSk2GCm1bJJ8QH-oH9Jv6qy0dqNSWtCTd1hpd2Z2z4zngtCes0ooq2wa1DGl3JepMtKm2muSWWNc1hYw_XrKT87plwt2ER1uTQyr3JyJ7UHtaht85PtgJgB4VkyKT1ff0tA1Kvy7Glto3Ec7GcmlHKCdw_Hp5GwjUSy0JOSxQFrndSE5bZOxANfQVEpONtHwjAVHANnnYBHIkPl3555qy_lvD-3dWTCXr-d_A6V_xlbeuayOH6GHEWXig04sHqN7vnqCdru-k7dP0XcQDnxWLzyuS_zzR3oEgLOaVxie6YzgzyFnBAi68FmP9aWeA4rE07XxS7te1M28wbpyeNI1_G7CNOObGFLbTjPpyrU2OPh58WS9gO3Ty9veFM_Q-fF4enSSxn4MqQUctEpzSxwxOdxpxpRmREonGPNUlSPlqQbV544ZpWVAdQaAIYwryUdWG9Btx1T-HA2quvIvEXaaZ87mYJ7miqpMG8EpEAkvpeOa5gn6sNn94qoru1G05gpjReBSEbmUoMPAmi1NKJbd_lAvL4uoe0VeSrinjZBuZKmwYLRpmXnHHBFeCOIS9C4wtugyT7cqXxxwxRXgNZYl6GNLEZQeuGp1zF2AxYRt7lEOe5SgrLY3vBeF5z_LGm4kq4hnSlP81oAEvd8OhxeEOLnK1-uWJqcUTFiZoBedIG5fBJqQSYCbCRI9Ee1tXn-kms_aiuNCqoAjX_37s16jB2ERIaadkCEarJZr_wYg28q8jXr5CwK6PNU priority: 102 providerName: ProQuest – databaseName: Scholars Portal Journals: Open Access dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3bahRBEG1iJJIX8e7oqi1EfBqzPdPXB5EYEqIQWWQDeRv6NtmFZUb3gtkP8If8EL_J6p6ZNRMCgrBP2zU9dFedrlNDdRVCe84qoayyaYBjSrkvU2WkTbXXJLPGuCwWMD39wk_O6Odzdr6Fum6j7QYubgztQj-ps_ns3eX39QcA_PsIeMZC_E72ORB5ydgtdDsDnxiSu07_En0WWhPytlBa8_WF5DReygJ-Q1MpOemy4q9NuIvuwKOZlIEiX3FdscL_5hzfmYQI-sf0Jp56Pd3yiv86vofutsQTHzSWch9t-eoB2mlaUa4fop9gL_hrPfO4LvHvX-khcNBqWmH4jScEfwrXSECgyaj1WF_oKRBLPF4ZP7erWb2YLrCuHB41PcAXYZqjyzbLNk4zaiq4LnD49ItHqxkAQM_XvSkeobPjo_HhSdq2aEgtUKNlmlviiMnBzRlTmiEpnWDMU1UOlacaTgPumFFaBqJngCvCuJJ8aLUBuDum8sdou6or_xRhp3nmbA4Ra66oyrQRnIKQ8FI6rmmeoDfd7hffmkocRYxgGCuCwopWYQn6GFSzkQn1s-Mf9fyiaOFY5KUE122EdENLhYU4TsvMO-aI8EIQl6BXQbFFcxl1cwoUB1xxBRSOZQl6GyWCZYJWrW6vM8Biwjb3JAc9ScCv7Q3vtcbzj2UNOssqOpQUEDtDRKmYFAl6vRkOLwipc5WvV1EmpxSiWpmgJ40hbl7UWXaCRM9Ee5vXH6mmk1iEXEgVqOWz_37yOdoN6wsZ8IQM0PZyvvIvgOAtzcuI3T8AFkpy priority: 102 providerName: Scholars Portal |
Title | The Role of β-Catenin in Th1 Immune Response against Tuberculosis and Profiles of Expression in Patients with Pulmonary Tuberculosis |
URI | https://dx.doi.org/10.1155/2021/6625855 https://www.ncbi.nlm.nih.gov/pubmed/33628846 https://www.proquest.com/docview/2491749587 https://search.proquest.com/docview/2493449668 https://pubmed.ncbi.nlm.nih.gov/PMC7892223 https://doaj.org/article/3f8036b78d0c47c096a82ed5d17e771d |
Volume | 2021 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba9swFBZtR2EvY_d66zINOvbkJrYlS3psQ0q2kZKFFPJmdEtjSO2SC1tf9rY_tB-y37Qj2Q71GAwGQQ_RsYx0zvH5jjgXhE6MFkxooUOnjiFJ7TwUiutQWhnFWikT-wKmo8t0eEU-zehsD9EmF8YH7WuVnxbLm9MiX_jYytsb3W3ixLrjUZ9x4cxadx_tg_ltu-jUdSFM65po1UVLlBCffwVQhoScp1ETAE-p8_2jbgpOAKeuiQ08GnPu0PA9K-WL-e8-2YcL5yx_zf8GSf-MrLxnqi4eo0c1xsRn1V6eoD1bPEWHVdfJu2foB4gGnpRLi8s5_vUz7APcLPICw2-6iPBHlzECBFXwrMXyWuaAIfF0q-xKb5flOl9jWRg8rtp9r90yg291QK1fZlwVa11jd8uLx9slyLpc3bWWeI6uLgbT_jCsuzGEGlDQJkx0ZCKVgEVTaq560dwwSi0R856wRILip4YqIbnDdApgIcwLnva0VKDZhorkBTooysIeIWxkGhudgHOaCCJiqVhKgIhZzk0qSRKg983pZ7dV0Y3MOyuUZo5hWc2wAJ071uxoXKls_0e5us5qgcmSOQcrrRg3PU2YBpdN8tgaaiJmGYtMgN46xmZV3ulO4bOzVKQC0BqNA_TBUziVB65qWWcuwGbcMbcoj1uUoKq6NX1SC88_tnXcSFZWf1HWGbjJ4DwKylmA3u2m3QtclFxhy62nSQgBB5YH6GUliLsXNZIdINYS0dbhtWdA_Xy98VrdXv33k6_RQ7c_F-weRcfoYLPa2jeA5TaqAxo8Yx304HxwOZ50_I0IjJ-_cBhHxI_fBzBOhrOO1_PfVHpL3A |
link.rule.ids | 230,314,727,780,784,863,864,877,878,885,2102,12056,21388,24318,27924,27925,31719,31720,33744,33745,43310,43805,53791,53793,73745,74302 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3dbtMwFLag0wQ3iN8RKMxIQ1xFqxM7tq_QNnXaYKuqqZN2F_kva6UqGU0r2APwQjwIz8Rx4pYFIZByVR858fmxv3N6fA5Ce9ZILo00sTfHmGauiKUWJlZOkcRobZOmgOn5KDu5pJ-u2FUIuNUhrXK9JzYbta2Mj5Hvg5sA4FkywT_efIl91yj_72pooXEfbfnK6ayHtg6Ho_HFWqOYb0mYhQJpbdSFpLS5jAW4hsZCZGSdDc-YDwSQ_Qw8AuFv_t05p5py_ptNe3vq3eWvs7-B0j9zK-8cVseP0aOAMvFBqxZP0D1XPkXbbd_J22foOygHvqjmDlcF_vkjPgLAWc5KDM9kSvCpvzMCBG36rMPqWs0AReLJSruFWc2relZjVVo8bht-136a4beQUttMM27LtdbYx3nxeDUH9qnFbWeK5-jyeDg5OolDP4bYAA5axqkhlmjgM9G60ANSWM6Yo7IYSEcVmH5mmZZKeFSnARjCuBTZwCgNtm2ZTF-gXlmV7iXCVmWJNSm4p6mkMlGaZxSIuBPCZoqmEXq_5n5-05bdyBt3hbHcSykPUorQoRfNhsYXy25-qBbXebC9PC0EnNOaCzswlBtw2pRInGWWcMc5sRHa9YLN25unG5PPDzKZScBrLInQh4bCGz1I1ahwdwEW49ncoex3KMFYTWd4LyjPf5bVX2tWHvaUOv9tARF6txn2L_B5cqWrVg1NSim4sCJCO60ibl4ElpAIgJsR4h0V7TCvO1LOpk3FcS6kx5Gv_v1Zu-jByeT8LD87HX1-jR76Bfn8dkL6qLdcrNwbgG9L_TbY6C_1KD-9 |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1bb9MwFLag0xAviDuBwow0xFO0OrFj-wlto9XGpaqmTtpb5FvWSlUymlawH8Af4ofwmzhO3LIgBFKe6iMn9rl9xz0-B6F9aySXRprYq2NMM1fEUgsTK6dIYrS2SVPA9PM4OzmnHy7YRch_qkNa5cYmNobaVsafkR9AmADgWTLBD4qQFjF5P3p39SX2HaT8P62hncZttANecZD00M7RcDw520gX8-0Js1AsrT2BISltLmYBxqGxEBnZZMYz5g8FyEEG0YHwtwBv-KymtP_WgO_OfOj8df43gPpnnuUNxzW6j-4FxIkPWxF5gG658iHabXtQXj9C30FQ8Fm1cLgq8M8f8TGAz3JeYnimM4JP_f0RIGhTaR1Wl2oOiBJP19otzXpR1fMaq9LiSdv8u_bTDL-F9NpmmklburXG_swXT9YL2D61vO5M8Ridj4bT45M49GaIDWCiVZwaYolOwb9pXegBKSxnzFFZDKSjCsxAZpmWSniEpwEkwrgU2cAoDXpumUyfoF5Zle4ZwlZliTUphKqppDJRmmcUiLgTwmaKphF6s9n9_KotwZE3oQtjuedSHrgUoSPPmi2NL5zd_FAtL_Ogh3laCPDZmgs7MJQbCOCUSJxllnDHObER2vOMzdtbqFv1zw8zmUnAbiyJ0NuGwhsA4KpR4R4DLMZvc4ey36EExTWd4f0gPP9ZVn8jWXmwL3X-Wxsi9Ho77F_gc-ZKV60bmpRSCGdFhJ62grh9EWhCIgB6Roh3RLSzed2Rcj5rqo9zIT2mfP7vz9pDd0A980-n448v0F2_Hp_qTkgf9VbLtXsJSG6lXwUV_QU-RkPq |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Role+of+%CE%B2-Catenin+in+Th1+Immune+Response+against+Tuberculosis+and+Profiles+of+Expression+in+Patients+with+Pulmonary+Tuberculosis&rft.jtitle=Journal+of+immunology+research&rft.au=Xiong%2C+Kunlong&rft.au=Niu%2C+Jinxia&rft.au=Zheng%2C+Ruijuan&rft.au=Liu%2C+Zhonghua&rft.date=2021-02-11&rft.pub=Hindawi&rft.issn=2314-8861&rft.eissn=2314-7156&rft.volume=2021&rft_id=info:doi/10.1155%2F2021%2F6625855&rft_id=info%3Apmid%2F33628846&rft.externalDBID=PMC7892223 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2314-8861&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2314-8861&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2314-8861&client=summon |