Emerging ideas about kisspeptin– GPR54 signaling in the neuroendocrine regulation of reproduction

Neurons that produce gonadotropin-releasing hormone (GnRH) drive the reproductive axis, but the molecular and cellular mechanisms by which hormonal and environmental signals regulate GnRH secretion remain poorly understood. Kisspeptins are products of the Kiss1 gene, and the interaction of kisspepti...

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Published inTrends in neurosciences (Regular ed.) Vol. 30; no. 10; pp. 504 - 511
Main Authors Kauffman, Alexander S, Clifton, Donald K, Steiner, Robert A
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.10.2007
Elsevier Science
Elsevier Sequoia S.A
Subjects
Animals
Biological and medical sciences
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
General aspects. Models. Methods
Genes
Hormones
Humans
Kisspeptins
Neurology
Neurosciences
Neurosecretory Systems - metabolism
Puberty
Receptors, G-Protein-Coupled - metabolism
Receptors, Kisspeptin-1
Reproduction - physiology
Reproductive system
Signal Transduction - physiology
Tumor Suppressor Proteins - physiology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vertebrates: nervous system and sense organs
Hormone
Steroid
Gene product
Interaction
Central nervous system
Sex
Neuroendocrine regulation
Review
Encephalon
Signal transduction
Neuron
Timing
Biological receptor
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Abstract Neurons that produce gonadotropin-releasing hormone (GnRH) drive the reproductive axis, but the molecular and cellular mechanisms by which hormonal and environmental signals regulate GnRH secretion remain poorly understood. Kisspeptins are products of the Kiss1 gene, and the interaction of kisspeptin and its receptor GPR54 plays a crucial role in governing the onset of puberty and adult reproductive function. This review discusses the latest ideas about kisspeptin–GPR54 signaling in the neuroendocrine regulation of reproduction, with special emphasis on the role of Kiss1 and kisspeptin in the negative and positive feedback control of gonadotropin secretion by sex steroids, timing of puberty onset, sexual differentiation of the brain and photoperiodic regulation of seasonal reproduction.
AbstractList Neurons that produce gonadotropin-releasing hormone (GnRH) drive the reproductive axis, but the molecular and cellular mechanisms by which hormonal and environmental signals regulate GnRH secretion remain poorly understood. Kisspeptins are products of the Kiss1 gene, and the interaction of kisspeptin and its receptor GPR54 plays a crucial role in governing the onset of puberty and adult reproductive function. This review discusses the latest ideas about kisspeptin-GPR54 signaling in the neuroendocrine regulation of reproduction, with special emphasis on the role of Kiss1 and kisspeptin in the negative and positive feedback control of gonadotropin secretion by sex steroids, timing of puberty onset, sexual differentiation of the brain and photoperiodic regulation of seasonal reproduction.
Neurons that produce gonadotropin-releasing hormone (GnRH) drive the reproductive axis, but the molecular and cellular mechanisms by which hormonal and environmental signals regulate GnRH secretion remain poorly understood. Kisspeptins are products of the Kiss I gene, and the interaction of kisspeptin and its receptor GPR54 plays a crucial role in governing the onset of puberty and adult reproductive function. This review discusses the latest ideas about kisspeptin-GPR54 signaling in the neuroendocrine regulation of reproduction, with special emphasis on the role of Kiss1 and kisspeptin in the negative and positive feedback control of gonadotropin secretion by sex steroids, timing of puberty onset, sexual differentiation of the brain and photoperiodic regulation of seasonal reproduction. [PUBLICATION ABSTRACT]
Neurons that produce gonadotropin-releasing hormone (GnRH) drive the reproductive axis, but the molecular and cellular mechanisms by which hormonal and environmental signals regulate GnRH secretion remain poorly understood. Kisspeptins are products of the Kiss1 gene, and the interaction of kisspeptin and its receptor GPR54 plays a crucial role in governing the onset of puberty and adult reproductive function. This review discusses the latest ideas about kisspeptin–GPR54 signaling in the neuroendocrine regulation of reproduction, with special emphasis on the role of Kiss1 and kisspeptin in the negative and positive feedback control of gonadotropin secretion by sex steroids, timing of puberty onset, sexual differentiation of the brain and photoperiodic regulation of seasonal reproduction.
Author Steiner, Robert A
Kauffman, Alexander S
Clifton, Donald K
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Issue 10
Keywords Hormone
Steroid
Gene product
Interaction
Central nervous system
Sex
Neuroendocrine regulation
Review
Encephalon
Signal transduction
Neuron
Timing
Biological receptor
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pascalfrancis_primary_19218857
elsevier_sciencedirect_doi_10_1016_j_tins_2007_08_001
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PublicationCentury 2000
PublicationDate 2007-10-01
PublicationDateYYYYMMDD 2007-10-01
PublicationDate_xml – month: 10
  year: 2007
  text: 2007-10-01
  day: 01
PublicationDecade 2000
PublicationPlace Oxford
PublicationPlace_xml – name: Oxford
– name: England
– name: Amsterdam
PublicationTitle Trends in neurosciences (Regular ed.)
PublicationTitleAlternate Trends Neurosci
PublicationYear 2007
Publisher Elsevier Ltd
Elsevier Science
Elsevier Sequoia S.A
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– name: Elsevier Science
– name: Elsevier Sequoia S.A
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Snippet Neurons that produce gonadotropin-releasing hormone (GnRH) drive the reproductive axis, but the molecular and cellular mechanisms by which hormonal and...
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SubjectTerms Animals
Biological and medical sciences
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
General aspects. Models. Methods
Genes
Hormones
Humans
Kisspeptins
Neurology
Neurosciences
Neurosecretory Systems - metabolism
Puberty
Receptors, G-Protein-Coupled - metabolism
Receptors, Kisspeptin-1
Reproduction - physiology
Reproductive system
Signal Transduction - physiology
Tumor Suppressor Proteins - physiology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vertebrates: nervous system and sense organs
Title Emerging ideas about kisspeptin– GPR54 signaling in the neuroendocrine regulation of reproduction
URI https://www.clinicalkey.es/playcontent/1-s2.0-S0166223607002123
https://dx.doi.org/10.1016/j.tins.2007.08.001
https://www.ncbi.nlm.nih.gov/pubmed/17904653
https://www.proquest.com/docview/218698500/abstract/
https://search.proquest.com/docview/20817522
https://search.proquest.com/docview/68364479
Volume 30
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