Real-time imaging of the medullary circuitry involved in the generation of spontaneous muscle sympathetic nerve activity in awake subjects

• Published in: Human brain mapping Vol. 31; no. 4; pp. 539 - 549
• Main Authors: Macefield, Vaughan G., Henderson, Luke A.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2010; Wiley-Liss
• Subjects: Adolescent; Adult; baroreflex; Biological and medical sciences; Blood Pressure - physiology; CVLM; Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation; Female; Fundamental and applied biological sciences. Psychology; Humans; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Imaging - methods; Male; Medical sciences; Medulla Oblongata - physiology; medullary nuclei; Microelectrodes; Muscle, Smooth, Vascular - innervation; Muscle, Smooth, Vascular - physiology; Nerve Fibers, Unmyelinated - physiology; Nervous system; Neural Conduction; NTS; Oxygen - blood; Peroneal Nerve - physiology; Radiodiagnosis. Nmr imagery. Nmr spectrometry; RVLM; Signal Processing, Computer-Assisted; sympathetic nervous system; Sympathetic Nervous System - physiology; Time Factors; Vertebrates: nervous system and sense organs; Wakefulness; Young Adult; Human; Sympathetic nerve; medullary nuclei; Nervous system diseases; RVLM; Radiodiagnosis; Autonomic nervous system; Baroreflex; Muscle; CVLM; Sympathetic nervous system; NTS

To understand the central neural processes involved in blood pressure regulation we recorded muscle sympathetic nerve activity (MSNA) via a tungsten microelectrode in the common peroneal nerve while performing functional magnetic resonance imaging (fMRI) of the brainstem at 3T. Blood oxygen level de...