Mapping reliability in multicenter MRI: Voxel-based morphometry and cortical thickness

• Published in: Human brain mapping Vol. 31; no. 12; pp. 1967 - 1982
• Main Authors: Schnack, Hugo G., van Haren, Neeltje E.M., Brouwer, Rachel M., van Baal, G. Caroline M., Picchioni, Marco, Weisbrod, Matthias, Sauer, Heinrich, Cannon, Tyrone D., Huttunen, Matti, Lepage, Claude, Collins, D. Louis, Evans, Alan, Murray, Robin M., Kahn, René S., Hulshoff Pol, Hilleke E.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.12.2010; Wiley-Liss
• Subjects: Anthropometry - methods; Biological and medical sciences; brain; Brain Mapping - methods; Brain Mapping - standards; calibration; Cerebral Cortex - anatomy & histology; Cerebral Cortex - physiology; cortical thickness; Genetic Variation - physiology; heritability; Humans; Image Processing, Computer-Assisted - methods; Image Processing, Computer-Assisted - standards; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Imaging - instrumentation; Magnetic Resonance Imaging - methods; Magnetic Resonance Imaging - standards; Medical sciences; MRI; multi-center; multi-site; multicenter; Nervous system; Nervous system involvement in other diseases. Miscellaneous; Neurology; Organ Size - physiology; Radiodiagnosis. Nmr imagery. Nmr spectrometry; reliability; voxel-based morphometry (VBM); voxel-based morphometry (VBM); Cartography; multi-site; Nervous system diseases; Radiodiagnosis; multi-center; MRI; cortical thickness; Central nervous system; Calibration; brain; Nuclear magnetic resonance imaging; Encephalon; Voxel; multicenter; Heritability; Reliability; Morphometry

Multicenter structural MRI studies can have greater statistical power than single‐center studies. However, across‐center differences in contrast sensitivity, spatial uniformity, etc., may lead to tissue classification or image registration differences that could reduce or wholly offset the enhanced...