Executive dysfunction and periventricular diffusion tensor changes in amnesic mild cognitive impairment and early Alzheimer's disease

• Published in: Human brain mapping Vol. 30; no. 11; pp. 3826 - 3836
• Main Authors: Chen, Ta-Fu, Chen, Ya-Fang, Cheng, Ting-Wen, Hua, Mau-Sun, Liu, Hon-Man, Chiu, Ming-Jang
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.11.2009; Wiley-Liss
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - pathology; Alzheimer Disease - physiopathology; Alzheimer's disease; Analysis of Variance; Anisotropy; Biological and medical sciences; Brain Mapping; Cerebral Ventricles - pathology; Cognition Disorders - pathology; Cognition Disorders - physiopathology; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dementia - pathology; Dementia - physiopathology; Diffusion Magnetic Resonance Imaging - methods; diffusion tensor imaging; executive function; Executive Function - physiology; Female; Humans; Imaging, Three-Dimensional - methods; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; mild cognitive impairment; Nervous system; Neurology; Neuropsychological Tests; periventricular white matter; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Statistics as Topic; Executive function; Nervous system diseases; Radiodiagnosis; Alzheimer disease; Diffusion imaging; White matter; Cerebral disorder; Diffusion tensor; Dysfunction; periventricular white matter; Central nervous system disease; diffusion tensor imaging; Degenerative disease; mild cognitive impairment; Alzheimer's disease

Our aim in this study was to explore the neural substrates of executive function in frontal and nonfrontal white matter using diffusion tensor imaging (DTI). We studied the relationship between executive dysfunction and DTI measurements on 13 subjects with amnesic mild cognitive impairment (aMCI), 1...