Cell therapy for spinal cord injury using induced pluripotent stem cells - Nagoshi, Narihito; Tsuji, Osahiko; Nakamura, Masaya; Okano, Hideyuki (Regenerative therapy, 2019)
Keywords: Clinical application; Induced pluripotent stem cells; Neural precursor cells; Review; Spinal cord injury; Clinical application; CST; SLA; HMGB1; Spinal cord injury; PBMCs; drNPCs; iPSCs; MLR; OPCs; ASIA; Induced pluripotent stem cells; CiRA; Neural precursor cells; NPCs; SCI; NHPs; GCV; CSPGs; HLA; GSI; C-ABC; ESCs; HSVtk; CiRA, the Center for iPS Cell Research and Application; HLA, human leukocyte antigen; C-ABC, chondroitinase ABC; SCI, spinal cord injury; CSPGs, chondroitin sulfate proteoglycans; NPCs, neural precursor cells; drNPCs, directly reprogrammed neural precursor cells; GSI, γ-secretase inhibitor; HSVtk, herpes simplex virus type I thymidine kinase; CST, corticospinal tract; GCV, ganciclovir; ASIA, American Spinal Injury Association; iPSCs, induced pluripotent stem cells; PBMCs, peripheral blood mononuclear cells; SLA, swine leukocyte antigen; ESCs, embryonic stem cells; MLR, mixed lymphocyte reaction; NHPs, nonhuman primates; HMGB1, high mobility group box-1; OPCs, oligodendrocyte progenitor cells