Size-dependent hepatic differentiation of human induced pluripotent stem cells spheroid in suspension culture

• Published in: Regenerative therapy Vol. 12; pp. 66 - 73
• Main Authors: Torizal, Fuad Gandhi, Kimura, Keiichi, Horiguchi, Ikki, Sakai, Yasuyuki
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.12.2019; Japanese Society for Regenerative Medicine; Elsevier
• Subjects: Hepatic differentiation; hiPSCs; iHeps; Size-dependent; Spheroid; iHeps; hiPSCs; Spheroid; Hepatic differentiation; Size-dependent

Suspension culture of three-dimensional (3D) spheroid of human induced pluripotent stem cells (hiPSCs) has been known as a potential method to enhance the scalability of hepatic differentiation of hiPSCs. However, the impact of size-related factor of initial formed spheroid were not largely consider...