Prevalence of dermal trypanosomes in suspected and confirmed cases of gambiense human African trypanosomiasis in Guinea

• Published in: PLoS neglected tropical diseases Vol. 18; no. 8; p. e0012436
• Main Authors: Soumah, Alseny M’mah, Camara, Mariame, Kaboré, Justin Windingoudi, Sadissou, Ibrahim, Ilboudo, Hamidou, Travaillé, Christelle, Camara, Oumou, Tichit, Magali, Kaboré, Jacques, Boiro, Salimatou, Crouzols, Aline, Ngoune, Jean Marc Tsagmo, Hardy, David, Camara, Aïssata, Jamonneau, Vincent, MacLeod, Annette, Bart, Jean-Mathieu, Camara, Mamadou, Bucheton, Bruno, Rotureau, Brice
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 19.08.2024; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Analysis; Biology and Life Sciences; Biopsy; Care and treatment; Child; Diagnosis; DNA, Protozoan - genetics; Dosage and administration; Female; Guinea - epidemiology; Humans; Immunohistochemistry; Life Sciences; Male; Medicine and Health Sciences; Middle Aged; Pentamidine isethionate; Prevalence; Prospective Studies; Research and Analysis Methods; Skin; Skin - parasitology; Skin - pathology; Social Sciences; Trypanosoma brucei gambiense - isolation & purification; Trypanosomiasis; Trypanosomiasis, African - diagnosis; Trypanosomiasis, African - epidemiology; Trypanosomiasis, African - parasitology; Young Adult; Guinea

The skin is an anatomical reservoir for African trypanosomes, yet the prevalence of extravascular parasite carriage in the population at risk of gambiense Human African Trypanosomiasis (gHAT) remains unclear. Here, we conducted a prospective observational cohort study in the HAT foci of Forecariah a...