Differential expression of tissue factor mRNA and protein expression in murine sepsis. The role of the granulocyte revisited

• Published in: Thrombosis and haemostasis Vol. 95; no. 2; p. 348
• Main Authors: de Waard, Vivian, Hansen, Hjalmar R, Spronk, Henri H M, Timmerman, Janneke J, Pannekoek, Hans, Florquin, Sandrine, Reitsma, Pieter H, ten Cate, Hugo
• Format: Journal Article
• Language: English
• Published: Germany 01.02.2006
• Subjects: Animals; Endotoxemia; Female; Fibrin - metabolism; Gene Expression Regulation - drug effects; Granulocytes - metabolism; Granulocytes - physiology; Immune Sera; Inflammation - genetics; Kidney; Lipopolysaccharides - pharmacology; Mice; Protein Transport; Rabbits; RNA, Messenger - analysis; Sepsis - genetics; Spleen; Thromboplastin - analysis; Thromboplastin - genetics; Thromboplastin - metabolism; Tissue Distribution

Tissue factor (TF) is a transmembrane protein, which is essential for initiation of the coagulation cascade. TF has been reported to play an important role in the progression of endotoxin (lipopolysaccharide, LPS)-mediated endotoxemia, being induced in numerous tissues, such as kidney, spleen and lu...