Frequent PIK3CA mutations in eutopic endometrium of patients with ovarian clear cell carcinoma

• Published in: Modern pathology Vol. 34; no. 11; pp. 2071 - 2079
• Main Authors: Murakami, Kosuke, Kanto, Akiko, Sakai, Kazuko, Miyagawa, Chiho, Takaya, Hisamitsu, Nakai, Hidekatsu, Kotani, Yasushi, Nishio, Kazuto, Matsumura, Noriomi
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 01.11.2021; Nature Publishing Group US; Elsevier Limited
• Subjects: 45/77; 631/67/1517/1709; 631/67/395; Adenocarcinoma, Clear Cell - genetics; Adenocarcinoma, Clear Cell - pathology; Adult; Biomarkers, Tumor - genetics; Class I Phosphatidylinositol 3-Kinases - genetics; Cysts; DNA Mutational Analysis; Early Detection of Cancer; Endometriosis; Endometriosis - genetics; Endometrium; Endometrium - metabolism; Endometrium - pathology; Female; Gene frequency; Glands; Humans; Laboratory Medicine; Medicine; Medicine & Public Health; Middle Aged; Mutation; Mutation - genetics; Mutation hot spots; Ovarian cancer; Ovarian carcinoma; Ovarian Neoplasms - genetics; Ovarian Neoplasms - pathology; Paraffin; Pathology; Polymerase Chain Reaction; Stroma; Tumors

Recent studies have reported cancer-associated mutations in normal endometrium. Mutations in eutopic endometrium may lead to endometriosis and endometriosis-associated ovarian cancer. We investigated PIK3CA mutations (PIK3CAm) for three hotspots (E542K, E545K, H1047R) in eutopic endometrium in patie...